Results 101 to 110 of about 116,988 (242)
Cardiovascular ToxicologyMyocardial infarction (MI) is a lethal cardiovascular disease worldwide. Emerging evidence has revealed the critical role of gut dysbiosis and impaired gut-brain axis in the pathological progression of MI.
Tong Zhu +8 more
semanticscholar +1 more source
Journal of International Medical Research, 2020 Objective To investigate the effects of tanshinone IIA on the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway in angiotensin II-treated hepatic stellate cells (HSCs).
Guo-wei Wei +3 more
doaj +1 more source
Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.ABSTRACT Background Benign tracheal stenosis, characterized by granulation hyperplasia, is a rare and serious disease threatening human health. Interventional bronchoscopy demonstrates limited therapeutic efficacy and poses a risk of re‐injury to the airway.
Dengyuan Li +4 more
wiley +1 more source
Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases.
Drug design, development and therapy, 2020 Salvia miltiorrhiza: (Danshen) is a significant (traditional Chinese medication) natural remedy, enhancing blood circulation and clear blood stasis. In this view, it is widely used against several heart diseases, eg, cardiomyopathy, arrhythmia, and congenital heart defects.
Guo,Rui +6 more
openaire +4 more sources
Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak +4 more
wiley +1 more source
Skin research and technologyPsoriasis is a persistent inflammatory dermatological disorder. Tanshinone IIA (tan‐IIA) is a biologically active compound in the self‐made Xiao‐Yin decoction (SMXYD) and exhibits diverse biological properties, such as anti‐proliferative and anti ...
Lei Fu +5 more
semanticscholar +1 more source
Effect of Tanshinone IIA in an In Vitro Model of Graves' Orbitopathy
Investigative Opthalmology & Visual Science, 2014 We investigated the therapeutic effect of nontoxic concentrations of tanshinone IIA (TanIIA) from Salvia miltiorrhiza in primary cultures of orbital fibroblasts from Graves' orbitopathy (GO).The effect of TanIIA on IL-1β-induced proinflammatory cytokine (IL-6, IL-8, MCP-1) expression was determined by real-time PCR.
Soolienah, Rhiu +4 more
openaire +3 more sources
New Phytologist, Volume 251, Issue 3, Page 1267-1282, August 2026.Biosynthesis and accumulation of tanshinones in the periderm of Salvia miltiorrhiza during secondary root growth. Summary Perennial herbs develop long‐lived roots that undergo repeated cycles of secondary growth, during which the periderm functions as a protective barrier and a major site of specialized metabolite accumulation.
Licheng Liu +19 more
wiley +1 more source
BMC Complementary Medicine and TherapiesSmall cell lung cancer (SCLC) is the most malignant lung cancer type. Due to the high rates of metastasis and drug resistance, effective therapeutic strategies remain lacking.
Yuxin Jiang +5 more
semanticscholar +1 more source
Tanshinone IIA Interacts with DNA by Minor Groove-Binding
Biological and Pharmaceutical Bulletin, 2008 Tanshen has long been widely used as a traditional Chinese medicine. Tanshinone IIA (Tan IIA) is the most abundant lipophilic constituent of Tanshen which has antitumor activity but the mechanism is poorly understood. Some preliminary reports hypothesized that it is a DNA intercalator and that the furano-o-quinone moiety could produce free radicals ...
Zhang, Zhichao +5 more
openaire +3 more sources