Results 121 to 130 of about 116,988 (242)

丹参酮IIA在人肝微粒体中的代谢研究

, 2009
Salvia miltiorrhiza (Danshen) has been widely used in China for the treatment of coronary heart disease, cerebrovascular disease, bone loss, hepatitis, hepatocirrhosis and chronic renal failure.
杨凌, 刘慧鑫
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Tanshinone IIA Promoted Autophagy and Inhibited Inflammation to Alleviate Podocyte Injury in Diabetic Nephropathy [PDF]

Yuan Li,1 Tong Wu,1 Hongye Li,2 Mingming Liu,2 Haiyan Xu1 1School of Basic Medicine, Xuzhou Medical University, Xuzhou, 221004, People’s Republic of China; 2Lianyungang Clinical School of Xuzhou Medical University, Lianyungang, 222006, People’s Republic ...
Li H, Li Y, Liu M, Wu T, Xu H
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Effect of tanshinone IIA on PCSK9 promoter activity.

, 2016
(A) Serially deleted PCSK9 promoter reporter constructs. (B) HepG2 cells were transfected with the serial deleted PCSK9 promoter reporter constructs for 24 h and then treated with the vehicle (0.1% DMSO) or tanshinone IIA (10 μM) for 24 h. The luciferase
Mi-Hsueh Tai (1510801), Hung-Chen Chen (789086), Jui-Hung Yen (143537), Pei-Yi Chen (143534), Ming-Jiuan Wu (143529)   +4 more
core   +1 more source

Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications

Frontiers in Pharmacology, 2019
Bioactive chemical constitutes from the root of Salvia miltiorrhiza classified in two major groups, viz., liposoluble tanshinones and water-soluble phenolics. Tanshinone IIA is a major lipid-soluble compound having promising health benefits.
Jie Ren, Li Fu, Shivraj Hariram Nile, Jun Zhang, Guoyin Kai, Guoyin Kai   +5 more
doaj   +1 more source

Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway

Cellular Physiology and Biochemistry, 2015
Aims: Estrogen plays a protective role in atherosclerosis. Our preliminary work demonstrated that the active conformation of Tanshinone IIA(TanIIA) is similar to the 17ß-estradiol and it can bind to the estrogen receptor.
Xin Liu, Chun-Yu Guo, Xiao-Juan Ma, Cai-Feng Wu, Ying Zhang, Ming-Yue Sun, Yu-Ting Pan, Hui-Jun Yin   +7 more
doaj   +1 more source

Tanshinone IIA Alleviates Pulmonary Fibrosis by Inhibiting Pyroptosis of Alveolar Epithelial Cells Through the MAPK Signaling Pathway

Phytotherapy Research
The current dearth of safe and efficacious pharmaceutical interventions for pulmonary fibrosis (PF) has prompted investigations into alternative treatments. This study aim to investigate the underlying mechanisms of Tanshinone IIA in the treatment of PF.
Yong Xu, Yi-Ran Wang, W. Peng, Huimin Bu, Yao Zhou, Qi Wu   +5 more
semanticscholar   +1 more source

Preparation, characterization, and in vivo evaluation of tanshinone IIA solid dispersions with silica nanoparticles

, 2013
Yan-rong Jiang,1,2 Zhen-hai Zhang,1 Qi-yuan Liu,1,2 Shao-ying Hu,1,2 Xiao-yun Chen,1,2 Xiao-bin Jia11Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, Jiangsu, People’s ...
Jia XB, Hu SY, Jiang YR, Zhang ZH, Chen XY, Liu QY   +5 more
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Tanshinone IIA protects against pulmonary arterial hypertension in broilers

Poultry Science, 2017
This investigation was conducted to study the effects of tanshinone IIA (TIIA) on pulmonary arterial hypertension (PAH) in broilers. Two-hundred newly hatched Arbor Acre commercial broilers were randomly divided into 3 groups. All groups, with the exception of the control group (tap water), were given NaCl water (0.3%) starting on the d 15, and ...
Guoliang, Hu, Yalu, Song, Shanlin, Ke, Huabin, Cao, Caiying, Zhang, Guangfu, Deng, Fei, Yang, Sihui, Zhou, Pei, Liu, Xiaoquan, Guo, Ping, Liu   +10 more
openaire   +2 more sources

Efficacy and mechanism of tanshinone IIA liquid nanoparticles in preventing experimental postoperative peritoneal adhesions in vivo and in vitro

, 2015
Fei Qin,1,* Yun Ma,1,* Xiao Li,2 Xian Wang,1 Yuanyi Wei,1 Chuqi Hou,3 Si Lin,1 Lianbing Hou,1 Chengxi Wang4 1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 2Department of Pharmacy, the Affiliated Hospital of Qingdao ...
Hou L, Li X, Lin S, Wang C, Ma Y, Qin F, Wang X, Hou C, Wei Y   +8 more
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Effect of tanshinone IIA on PCSK9 mRNA and protein expression.

, 2016
(A) HepG2 cells were cultured in LPDS medium and treated with the vehicle (0.1% DMSO) or tanshinone IIA (5 and 10 μM) for 24 h. PCSK9 mRNA expression was measured by RT-Q-PCR.
Mi-Hsueh Tai (1510801), Hung-Chen Chen (789086), Jui-Hung Yen (143537), Pei-Yi Chen (143534), Ming-Jiuan Wu (143529)   +4 more
core   +1 more source