Results 131 to 140 of about 116,988 (242)
Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives
Journal of Asian Natural Products Research, 2017 A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 μM) activity compared with esmolol (8.12 μM).
Yin-Lin, Qin +7 more
openaire +2 more sources
Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA
, 2012 [[abstract]]This study evaluates the proliferative effects of danshen and its monomer extract, tanshinone IIA, on Schwann cell proliferation. A piece of silicone rubber was guided across a 15-mm gap in the sciatic nerve of a rat.
;Chou, Ming-Chih;黃志揚;HUANG, CHIH-YANG;Lin, Chien-Chung
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Multi-omics elucidation of temporal patterns in tanshinone accumulation in Salvia miltiorrhiza
BMC Plant BiologySalvia miltiorrhiza is valued for tanshinones, but the dynamics and regulatory mechanisms of tanshinone accumulation from root expansion to harvest are unclear.
Mingzhi Zhong +11 more
doaj +1 more source
Tanshinone IIA: A new activator of human cardiac KCNQ1/KCNE1 (I Ks) potassium channels
, 2008 Tanshinone IIA, one of the main active components from Chinese herb Danshen, is widely used to treat cardiovascular diseases including arrhythmia in Asian countries especially in China.
Li, GR +7 more
core +1 more source
Journal of Ovarian ResearchBackground Tri-ortho-cresyl phosphate (TOCP), a widely used plasticizer, has been shown to impair ovarian function. While tanshinone IIA exhibits ovarian protective effects in aging models, its potential to counteract TOCP-induced ovarian damage and ...
Zhangqiang Ma +9 more
doaj +1 more source
Tanshinone IIA inhibits angiogenesis in human endothelial progenitor cells in vitro and in vivo
, 2018 [[abstract]]Accumulating evidence reports that bone marrow-derived endothelial progenitor cells (EPCs) regulate angiogenesis, postnatal neovascularization and tumor metastasis.
李湘萍;Lee, Hsiang-Ping;Yueh-Ching, L;Liu, Yueh-Ching;陳?均;Cehn, Po-Chun;Huai-Ching, T;Tai, Huai-Ching;Li, Te-Mao;Fong, Yi-Chin;Chih-Shiang;Chang, Chih-Shiang;Wu, Min-Huan;Chiu, Li-Pin;Wa, Chia-Jung;Wang, Chia-Jung;Che, Yi-Hsuan;Chen, Yi-Hsuan;Wu, Yih-Jer;湯智昕;Tang, Chih-Hsin;Wan, Shih-Wei;Wang, Shih-Wei
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Discover OncologyObjective This study aims to explore whether tanshinone IIA can act on paclitaxel-resistant non-small cell lung cancer A549/Tax and analyze the possible mechanisms involved. Methods Using the Cell Counting Kit-8 (CCK-8), we preliminarily analyzed whether
Fangjun Chen +2 more
doaj +1 more source
Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1. [PDF]
, 2006 Bone is a dynamic tissue that is regulated by the activity of bone-resorbing osteoclasts and boneforming osteoblasts. Excessive osteoclast forma - tion causes diseases such as osteoporosis and rheumatoid arthritis.
Kim, Ha-Neui +8 more
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Effect of tanshinone IIA on the cell viability in HepG2 cells.
, 2016 (A) Chemical structure of tanshinone IIA. (B) HepG2 cells were cultured in LPDS medium and treated with the vehicle (0.1% DMSO) or tanshinone IIA (1–20 μM) for 24 h. Cell viability was measured using an MTT assay.
Mi-Hsueh Tai (1510801) +4 more
core +1 more source
The Turkish Journal of GastroenterologyBackground/Aims: Hepatocellular carcinoma (HCC) is a molecularly heterogeneous solid malignancy that carries a dismal prognosis. Tanshinone IIA (Tan-IIA) is involved in the regulation of N6-methyladenosine (m6A) modification and plays an anti-tumor role
Ying Jiang +6 more
doaj +1 more source