Results 111 to 120 of about 116,988 (242)

In vitro anti-tumor activity of the tanshinone IIA against SKOV3 cells

, 2015
The aim of this study was to determine the anti-tumour activity of tanshinone IIA in SKOV3 cells. Results suggested that tanshinone IIA could significantly inhibit (IC50 value  =  19.6 μM) the proliferation and induce apoptosis of SKOV3 cells as ...
YingKai Hong (806292), Ju Huang (806291), Hao Lin (123504)   +2 more
core   +1 more source

Microglial Mitochondrial Dysfunction: The Storm Center of Post‐Stroke Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Stroke disrupts microglial mitochondrial homeostasis, leading to acute damage and metabolic dysfunction that amplify pro‐inflammatory signaling. Although quality control mechanisms initiate protective responses, persistent stress overwhelms them. The resulting imbalance drives a self‐reinforcing neuroinflammatory storm that exacerbates secondary brain ...
Ruchong Fan, Chuan Wang, Zi Lin, Shiling Chen, Chao Pan, Hao Nie, Chuan Qin, Xuan Wu, Zhouping Tang   +8 more
wiley   +1 more source

Inhibition of tanshinone IIA on renin activity protected against osteoporosis in diabetic mice

Pharmaceutical Biology, 2020
Context Salvia miltiorrhiza Bge. (Labiatae) (SMB) is applied clinically for management of diabetic osteoporosis in China, and research results has suggested its potential action on renin–angiotensin system (RAS). Objective This study screens and explores
Jingjing Zhang, Zixuan Cai, Min Yang, Lijuan Tong, Yan Zhang   +4 more
doaj   +1 more source

Multi‐Induction Strategies in Crops: Mechanisms, Synergistic Effects, and Sustainable Applications for Enhanced Secondary Metabolite Production

Food Frontiers, Volume 7, Issue 4, July 2026.
This review analyzes single/combined abiotic (light, water, nutrients, hormones) and biotic (microbes, yeast) elicitors regulating signaling, gene expression, and metabolism to boost plant secondary metabolites. It highlights synergistic multielicitor strategies for crop quality and functional foods, while critically addressing current limitations and ...
Yifei Sun, Daoyan Xiao, Xingyue Li, Zhaofei Wang, Maoqin Xia, Chao Song, Hong‐Lei Li   +6 more
wiley   +1 more source

Additional file 1 of Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis

, 2022
Additional file 1: Figure S1. The effects of Tanshinone IIA on the cell cycle distribution of breast cancer cells and viability of MCF-10A cells. A, B The effects of Tanshinone IIA on the cell cycle distribution were determined in MCF-7 (A) and MDA-MB ...
Shijun Wang (89455), Yinyin Zhou (9742465), Qi Jia (702670), Yin Lu (381049), Li Song (34475), Xuan Jiang (823419), Aiyun Wang (381046), Xiaoman Li (181664), Wenxing Chen (352859), Yuanyuan Wu (82054)   +9 more
core   +1 more source

Quantitative Determination and Validation of Four Ketones in Salvia miltiorrhiza Bunge Using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy

Molecules, 2020
Salvia mltiorrhiza Bunge (SMB) is native to China, whose dried root has been used as medicine. A few chromatographic- or spectrometric-based methods have already been used to analyze the lipid-soluble components in SMB.
Yuanyuan Li, Zhuoni Hou, Feng Su, Jipeng Chen, Xiaodan Zhang, Ling Xu, Dongfeng Yang, Zongsuo Liang   +7 more
doaj   +1 more source

Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor

, 2015
Xianxie Zhang,1 Yuguang Wang,2 Zengchun Ma,2 Qiande Liang,2 Xianglin Tang,2 Donghua Hu,2 Hongling Tan,2 Chengrong Xiao,2 Yue Gao2 1Air Force General Hospital of People’s Liberation Army, Beijing, People’s Republic of China; 2Department of ...
Hu D, Tan H, Zhang X, Gao Y, Ma Z, Wang Y, Xiao C, Liang Q, Tang X   +8 more
core  

Tanshinone IIA Regulates NRF2/NLRP3 Signal Pathway to Restrain Oxidative Stress and Inflammation in Uric Acid-Induced HK-2 Fibrotic Models

Endocrine, Metabolic & Immune Disorders - Drug Targets
Introduction This study aims to investigate the function and potential mechanism of Tanshinone IIA in uric acid-induced HK-2 fibrosis models. Materials and Methods An in vitro model of fibrosis was constructed using uric acid stimulation.
Weiliang Zhang, Jiashu Feng, Ruiqi Liu, Ting Xiang, Xin-Lin Wu   +4 more
semanticscholar   +1 more source

Anabolic Effect of the Traditional Chinese Medicine Compound Tanshinone IIA on Myotube Hypertrophy Is Mediated by Estrogen Receptor

, 2015
Skeletal muscle loss during menopause is associated with a higher risk of developing diabetes type II and the general development of the metabolic syndrome. Therefore, strategies combining nutritional and training interventions to prevent muscle loss are
Diel, P., Ngueu, S., Kulling, Sabine E., Zhao, Piwen, Hegevoss, J., Soukup, Sebastian Tobias   +5 more
core   +1 more source

Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation

Synthetic and Systems Biotechnology, 2016
Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking.
Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Wenzhao Wang, Fuhang Song, Huanqin Dai, Jingyu Zhang, Ronald J. Quinn, Tanja Grkovi, Houwei Luo, Lixin Zhang, Xueting Liu   +15 more
doaj   +1 more source