Results 111 to 120 of about 79,005 (262)

Danshensu Ethyl Ester Induces Ferroptosis Through Targeted Inhibition of SLC7A11 Transport Function in NSCLC

Thoracic Cancer, Volume 17, Issue 8, April 2026.
Danshensu ethyl ester (DEE) promotes ferroptosis by targeting and inhibiting the transport function of SLC7A11, independent of the p53 pathway, thereby inhibiting NSCLC. DEE reduces intracellular cysteine and glutathione (GSH) levels, while increasing reactive oxygen species (ROS) and malondialdehyde (MDA), thereby triggering ferroptosis.
Rui Yan, Sen Xu, Meng Yan, Dongyang Wu, Jingwen Zhang, Chunsheng Zhang, Jiale Liu, You‐Jie Li, Jiankai Feng, Gui‐Wu Qu, Shu‐Yang Xie   +10 more
wiley   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, Volume 59, Issue 4, April 2026.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Tanshinone IIA Protects Against Cardiac Hypertrophy via Inhibiting Calcineurin/Nfatc3 Pathway

International Journal of Biological Sciences, 2011
Pathological cardiac hypertrophy induced by adrenergic overactivation can subsequently develop to heart failure which remains as a leading cause of mortality worldwide.
Xueying Tan, Jianping Li, Xinyue Wang, Nan Chen, Benzhi Cai, Gang Wang, Hongli Shan, Deli Dong, Yanju Liu, Xingda Li, Fan Yang, Xin Li, Peng Zhang, Xueqi Li, Baofeng Yang, Yanjie Lu
doaj  

Aldose Reductase Inhibitory Activity of Chinese Crude Drug "Danshen" [PDF]

, 2000
漢薬“丹参”の基源植物である丹参（Salvia miltiorhiza）及び中国新彊において丹参（S.miltiorhiza）の代用品として用いられている新彊丹参（S.deserta）のアルドース還元酵素阻害活性成分を調べたところ，両者の活性成分は全く異なっていた。さらに，丹参（S.miltiorhiza）の代用品として用いられている10種を含む17種類のSalvia属植物について，水およびメタノールエキスのアルドース還元酵素阻害活性およびLC-MS分析を比較した結果も ...
手塚 康弘, 門田 重利
core   +1 more source

Mechanisms and Clinical Consequences of Vascular Calcification [PDF]

, 2012
Vascular calcification has severe clinical consequences and is considered an accurate predictor of future adverse cardiovascular events, including myocardial infarction and stroke.
Farquharson, Colin, Mackenzie, Neil C W, Macrae, Vicky E, Zhu, Dongxing   +3 more
core   +2 more sources

Targeting Oxidative Stress and Endothelial Dysfunction Using Tanshinone IIA for the Treatment of Tissue Inflammation and Fibrosis

Oxidative Medicine and Cellular Longevity, 2022
Salvia miltiorrhiza Burge (Danshen), a member of the Lamiaceae family, has been used in traditional Chinese medicine for many centuries as a valuable medicinal herb with antioxidative, anti‐inflammatory, and antifibrotic potential. Several evidence‐based
Tsuo-Cheng Lu, Yi-Hsiu Wu, Wei‐Yu Chen, Yu-Chiang Hung   +3 more
semanticscholar   +1 more source

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

Orthoquinone, Cyclic, and Acyclic α‐Diketone Natural Products: From Food Applications to Pharmacotherapy

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain, Daijie Wang, Satyajit D. Sarker, Lutfun Nahar, Nilufar Z. Mamadalieva, Jianbo Xiao   +5 more
wiley   +1 more source

Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

Experimental and Therapeutic Medicine, 2016
Tanshinone IIA is a chemical compound extracted from the root of traditional Chinese herb Salvia miltiorrhiza Bunge. Tanshinone IIA has been suggested to possess anti-inflammatory activity and antioxidizing capability. Recently, accumulating results have indicated the antitumor activity of tanshinone IIA; thus, it has attracted increasing attention. In
Yan-Mei, Xu, Guo-Hua, Ding, Jie, Huang, Yan, Xiong   +3 more
openaire   +3 more sources

Viral Pathogens and Pulmonary Fibrosis: EMT‐Driven Mechanisms and Insights From Traditional Chinese Medicine

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a serious progressive complication of the respiratory system, which is profoundly associated with persistent extracellular matrix (ECM) deposition, fibrosis, and disrupted tissue regeneration. Emerging evidence shows that epithelial–mesenchymal transition (EMT) acts as a key factor in the pathogenesis of ...
Ningzi Zang, Yingxu Wu, Pin Li, Yongming Liu, Shiwen Wang, Jiapeng Leng, Libin Zhan, Xiaodong Lyu, Lijian Pang, Jiaran Wang   +9 more
wiley   +1 more source