Results 91 to 100 of about 116,988 (242)

Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma

Experimental and Therapeutic Medicine, 2022
Head and neck squamous cell carcinoma (HNSCC) is a worldwide public health problem; its incidence is increasing and it is now the sixth most common cancer type worldwide.
W. Mao, Jian Ding, Yu Li, Ruo-Fei Huang, Bao-Xin Wang   +4 more
semanticscholar   +1 more source

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6606-6616, 30 August 2026.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu, Pan Li, Zizhuo Li, Jie Li, Chenggang Zhang, Yihua Wang, Weiming Kang, Xin Ye   +7 more
wiley   +1 more source

Tanshinone IIA destabilizes SLC7A11 by regulating PIAS4-mediated SUMOylation of SLC7A11 through KDM1A, and promotes ferroptosis in breast cancer

Journal of Advanced Research
Graphical ...
Na Luo, Ke-Jing Zhang, Xin Li, Yu Hu, Lei Guo   +4 more
semanticscholar   +1 more source

Effects of tanshinone IIA on PASMCs proliferation under normoxic and hypoxic conditions.

, 2013
(A–B) Effects of tanshinone IIA on the proliferation of PASMCs under normoxic (21% O2) and hypoxic (3% O2) conditions. Hypoxia for 24 h significantly promoted PASMCs proliferation.
Yi Liu (36759), Wen Niu (381056), Dun-Quan Xu (381054), Ying Luo (381053), Zhi-Chao Li (381058), Ming-Qing Dong (381057), Bo Zhang (6559), Hai-Ying Dong (381055)   +7 more
core   +1 more source

Tanshinone IIA attenuates interleukin-17A-induced systemic sclerosis patient-derived dermal vascular smooth muscle cell activation via inhibition of the extracellular signal-regulated kinase signaling pathway

Clinics, 2015
OBJECTIVE: Salvia miltiorrhiza has long been used to treat systemic sclerosis. Tanshinone IIA, one of the phytochemicals derived from the roots of Salvia miltiorrhiza, exhibits multiple biological activities.
Mengguo Liu, Ji Yang, Ming Li
doaj   +1 more source

Network Pharmacology Combined With Metabonomics and Transcriptomics Reveals the Mechanism of Rubus Chingii Hu in Alleviating Nephrotoxicity Caused by Tripterygium Glycosides Tablet

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Flow chart of RCH to improve TGT‐induced nephrotoxicity. ABSTRACT Researches on Tripterygium glycosides tablets (TGT) often overlook renal toxicity from prolonged use. Rubus chingii Hu (RCH) is beneficial to kidney health and has an unclear role in reducing nephrotoxicity.
Cong Zhang, Zepeng Zhang, Tong Zhou, Lei Zhang   +3 more
wiley   +1 more source

Photothermally enhanced antibacterial wound healing using albumin-loaded tanshinone IIA and IR780 nanoparticles

Frontiers in Bioengineering and Biotechnology
Chronic and infected wounds, particularly those caused by bacterial infections, present significant challenges in medical treatment. This study aimed to develop a novel nanoparticle formulation to enhance wound healing by combining antimicrobial and ...
Hai-Dong Chen, Yi-Mei Li, De-Xuan Chen, Yong Fang, Xu-Chu Gong, Kai-Kai Wang, Chaoqun Ma   +6 more
semanticscholar   +1 more source

Tanshinone IIA Inhibits Angiotensin II-Induced Cell Proliferation in Rat Cardiac Fibroblasts

, 2011
Tanshinone IIA extracted from Danshen, a popular medicinal herb used in traditional Chinese medicine, exhibits cardio-protective effects. However, the mechanism of its cardioprotective effect is not well established.
Tzu-Hurng Cheng, Paul Chan, Hong-Jye Hong, Po-Yuan Chen, Jaung-Geng Lin, Li-Jen Lin, Ju-Chi Liu   +6 more
core   +1 more source

Application of unmanned aerial vehicles in modern battlefields and their impact on post‐traumatic stress disorder in military personnel: A review

General Psychiatry, Volume 39, Issue 4, August 2026.
ABSTRACT The widespread adoption of unmanned aerial vehicles (UAVs) in military operations has profoundly transformed modern warfare, introducing new combat paradigms that significantly affect the psychological well‐being of service members. This review systematically examines the primary applications of UAVs on the battlefield and explores the complex
Yu Xue, Yufang Sun, Yongxian Zhang, Yongliang Zhang, Chenglin Sang, Dawei Zhang   +5 more
wiley   +1 more source