Results 91 to 100 of about 79,005 (262)

Alcoholic extracts of Russian sage (Salvia yangii) contain bioactive terpenoids with inhibitory activity against grapevine downy mildew (Plasmopara viticola)

open access: yesPest Management Science, EarlyView.
Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone   +5 more
wiley   +1 more source

Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB

open access: yesBiomedicine & Pharmacotherapy, 2021
Mastitis is a common disease occurs in breast-feeding mothers, but published data are poor. This study aimed to study the effects of Tanshinones on treating mastitis.Clinical trials performed in 58 breast-feeding mothers were carried out. B-ultrasound and blood test were used to measure the size of breast mass and the change of blood cell counts.
Lili, Yang   +6 more
openaire   +2 more sources

Tanshinone IIA Promotes Pulmonary Artery Smooth Muscle Cell Apoptosis in Vitro by Inhibiting the JAK2/STAT3 Signaling Pathway

open access: yesCellular Physiology and Biochemistry, 2014
Background: Tanshinone IIA inhibits the proliferation of pulmonary artery smooth muscle cells (PASMCs), but the potential mechanisms of its effects on PASMCs apoptosis remain unclear.
Minggang Chen   +5 more
doaj   +1 more source

Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis

open access: yesOpen Life Sciences, 2023
Articular cartilage degeneration caused by chondrocyte damage is the primary pathological mechanism of osteoarthritis (OA). Oxidative stress is correlated with chondrocyte injury by potentiating ferroptosis, a newly identified form of cell death.
Jin Xu   +3 more
semanticscholar   +1 more source

Cardiovascular Benefits of Salvia miltiorrhiza (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Akash Vikal   +6 more
wiley   +1 more source

Anti‐Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis [PDF]

open access: yesEvidence-Based Complementary and Alternative Medicine, 2014
Tanshinone IIA (Tan II A) is widely used in the treatment of cardiovascular diseases as an active component of Salvia miltiorrhiza Bunge. It has been demonstrated to have pleiotropic effects for atherosclerosis. From the anti‐inflammatory and immunomodulatory mechanism perspective, this paper reviewed major progresses of Tan IIA in antiatherosclerosis ...
Zhuo Chen, Hao Xu
openaire   +2 more sources

Tanshinone IIA Inhibits High Glucose-Induced Collagen Synthesis via Nuclear Factor Erythroid 2-Related Factor 2 in Cardiac Fibroblasts

open access: yesCellular Physiology and Biochemistry, 2018
Background/Aims: Diabetes is associated with increased incidence of myocardial dysfunction, which is partly characterized by interstitial and perivascular fibrosis.
Yi-Ting  Tsai   +6 more
doaj   +1 more source

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]

open access: yes, 2019
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y.   +3 more
core   +3 more sources

Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma

open access: yesExperimental and Therapeutic Medicine, 2022
Head and neck squamous cell carcinoma (HNSCC) is a worldwide public health problem; its incidence is increasing and it is now the sixth most common cancer type worldwide.
W. Mao   +4 more
semanticscholar   +1 more source

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