Results 71 to 80 of about 116,988 (242)

Preparation of tanshinone IIA self-soluble microneedles and its inhibition on proliferation of human skin fibroblasts

Chinese Herbal Medicines, 2023
Objective Hypertrophic scars (HS) are a variety of skin tissue fibrosis disease that occurs in human skin, the effective therapeutic method of which is still inaccessible up to now.
Yan-Shan Zhan, Xiao-Qi Xu, Xi Luo, Rui Liu, Yu-Jian Lin, Ping Zhao, Jun Shi   +6 more
semanticscholar   +1 more source

Proapoptotic and TRAIL-sensitizing constituents isolated from Salvia militiorrhiza (Danshen)

, 2014
Natural compounds isolated from medicinal plants are invaluable resources for drug discovery. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent unique by its cancer cell-specific proapoptotic action, but its ...
Chi-Shiuan Tsai, Liao, En-Chih, Ma, Song-Wei, Huang, Lan-Ru, Tsai, Chi-Shiuan, Chia-Che Chang, Chien-Hsing Lu, Lu, Chien-Hsing, Jyun-Yi Lin, Lai, Jui-Sheng, Tsing-Fen Ho, Ho, Tsing-Fen, Jui-Sheng Lai, Lan-Ru Huang, Chang, Chia-Che, En-Chih Liao, Lin, Jyun-Yi, Song-Wei Ma   +17 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Chemical structure of Tanshinone IIA.

, 2013
Chemical structure of Tanshinone IIA.
Xuemei Lin (317799), Yong Zhao (84950), Jing Zhao (21160), Xuemei Wu (317795), Lan Li (73597), Jingxian Wu (317800), Shanshan Yu (317797), Yanlin Chen (317793)   +7 more
core   +1 more source

RETRACTED: Tanshinone sensitized the antitumor effects of irradiation on laryngeal cancer via JNK pathway

Cancer Medicine, 2018
Laryngeal cancer is a common cancer occurred in the head and neck. Irradiation sensitivity is a problem affecting the treatment of laryngeal cancer. Tanshinone IIA has been reported to play an important role in treating multiple diseases; yet, whether ...
Hui Xu, Yu‐li Hao, Li‐na Xu, Liang Chen, Feng‐wei Xu   +4 more
doaj   +1 more source

The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line

Acta Pharmaceutica Sinica B, 2015
The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.
Jun Xie, Jiahui Liu, Heng Liu, Shihui Liang, Meigui Lin, Yueyu Gu, Taoli Liu, Dongmei Wang, Hui Ge, Sui-lin Mo   +9 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Effect of tanshinone IIA for myocardial ischemia/reperfusion injury in animal model: preclinical evidence and possible mechanisms

Frontiers in Pharmacology, 2023
Introduction: Tanshinone IIA (Tan IIA), the major active lipophilic ingredient of Radix Salviae Miltiorrhizae, exerts various therapeutic effects on the cardiovascular system.
P. Zhu, Jiayi Shen, R. Qian, Jian Xu, Chong Liu, Wuming Hu, Ying Zhang, Ling-Chun Lv   +7 more
semanticscholar   +1 more source

Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats

Molecular Medicine Reports, 2016
Multiple sclerosis (MS) is an inflammatory autoimmune neurodegenerative disease, which features focal demyelination and inflammatory cell infiltration of the brain and the spinal cord. Tanshinone IIA (TSIIA), one of the major fat‑soluble components of Salvia miltiorrhiza (Danshen), has anti‑inflammatory, immunoregulatory and neuroprotective activity ...
Yan, Jun, Yang, Xue, Han, Dong, Feng, Juan   +3 more
openaire   +3 more sources

Tanshinone IIA: A phytochemical as a promising drug candidate for neurodegenerative diseases

Pharmacological Research, 2021
Tanshinones, lipophilic diterpenes isolated from the rhizome of Salvia miltiorrhiza, have diverse pharmacological activities against human ailments including neurological diseases. In fact, tanshinones have been used to treat heart diseases, stroke, and vascular diseases in traditional Chinese medicine. During the last decade, tanshinones have been the
Lalita Subedi, Bhakta Prasad Gaire
openaire   +2 more sources