Results 61 to 70 of about 7,215 (115)

Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation

Synthetic and Systems Biotechnology, 2016
Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking.
Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Wenzhao Wang, Fuhang Song, Huanqin Dai, Jingyu Zhang, Ronald J. Quinn, Tanja Grkovi, Houwei Luo, Lixin Zhang, Xueting Liu   +15 more
doaj   +1 more source

Tanshinone IIA Promotes Pulmonary Artery Smooth Muscle Cell Apoptosis in Vitro by Inhibiting the JAK2/STAT3 Signaling Pathway

Cellular Physiology and Biochemistry, 2014
Background: Tanshinone IIA inhibits the proliferation of pulmonary artery smooth muscle cells (PASMCs), but the potential mechanisms of its effects on PASMCs apoptosis remain unclear.
Minggang Chen, Yumei Liu, Dan Yi, Liuping Wei, Yumei Li, Li Zhang   +5 more
doaj   +1 more source

RETRACTED: Tanshinone sensitized the antitumor effects of irradiation on laryngeal cancer via JNK pathway

Cancer Medicine, 2018
Laryngeal cancer is a common cancer occurred in the head and neck. Irradiation sensitivity is a problem affecting the treatment of laryngeal cancer. Tanshinone IIA has been reported to play an important role in treating multiple diseases; yet, whether ...
Hui Xu, Yu‐li Hao, Li‐na Xu, Liang Chen, Feng‐wei Xu   +4 more
doaj   +1 more source

Tanshinone IIA Selectively Enhances Hyperpolarization-Activated Cyclic Nucleotide–Modulated (HCN) Channel Instantaneous Current

Journal of Pharmacological Sciences, 2009
.: Tanshinone IIA, one of the main active components from the Chinese herb Danshen, is widely used to treat cardiovascular diseases in Asian countries, especially in China.
Qiansheng Liang, Le Yang, Zhaohua Wang, Sufang Huang, Shusheng Li, Guangtian Yang   +5 more
doaj   +1 more source

Influence of Tanshinone IIA on the Apoptosis of Human Esophageal Ec-109 Cells

Natural Product Communications, 2016
The induced-apoptosis effect and mechanism of human esophageal cancer Ec-109 cells via tanshinone IIA was investigated. The Ec-109 cells were cultured in vitro with different concentrations of tanshinone IIA (2 μg/mL, 4 μg/mL, or 8 μg/mL) for 12, 24, 36,
Yan-Qin Zhu, Bai-Yan Wang, Fang Wu, Yong-Kang An, Xin-Qiang Zhou   +4 more
doaj   +1 more source

MAPK3-MYB36-ARF1 module regulates the tanshinone formation in Salvia miltiorrhiza

Plant Signaling & Behavior
Salvia miltiorrhiza, known as Danshen, is a traditional Chinese medicinal plant with significant cardiovascular benefits, attributed to its secondary metabolites, particularly tanshinones.
Yongfeng Xie, Hao Liu
doaj   +1 more source

Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate Staphylococcus aureus pathogenicity

Virulence
Staphylococcus aureus (S. aureus) is a prevalent pathogen responsible for a wide range of diseases in humans, contributing to both hospital-acquired and community-acquired infections.
Shiyu Zhou, Haoyan Zou, Yueshan Xu, Dongbin Guo, Zhengjie Su, Li Wang, Bingmei Wang, Yicheng Zhao, Xiangyang Leng, Yanping Wang   +9 more
doaj   +1 more source

Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling

European Journal of Histochemistry
Tanshinone IIA is derived from Salvia miltiorrhiza and has multiple therapeutic targets and functions. The exact therapeutic effects on liver fibrosis as well as the underlying hepatoprotective mechanisms are still lacking.
Dan Wang, Qingquan Tan, Qing Zheng, Yanling Ma, Li Feng   +4 more
doaj   +1 more source

Content Determination and Chemical Clustering Analysis of Tanshinone and Salvianolic Acid in Salvia spp.

Metabolites
Salvia miltiorrhiza is one of the famous traditional Chinese medicines for treating cardiovascular and cerebrovascular diseases. Tanshinone and phenolic acids are the main active compounds of Salvia miltiorrhiza, whereas the distribution patterns of the ...
Feiyan Wang, Yufeng Bao, Furui Yang, Lu Yuan, Xinchun Han, Yanbo Huang, Yukun Wei, Lei Zhang, Zongqi Yang, Dongfeng Yang   +9 more
doaj   +1 more source

<i>Salvia miltiorrhiza</i> ultrafine powder improves ileal barrier function and health of hens during late laying period via TLR4/NF-κB-mediated macrophage polarization. [PDF]

Front Immunol
Meng C, Azad MAK, Lin W, Gui J, Cui Y, Lan W, Kong X.   +6 more
europepmc   +1 more source