Results 51 to 60 of about 2,182 (156)

Exploring SARS-CoV-2 Delta variant spike protein receptor-binding domain (RBD) as a target for tanshinones and antimalarials

, 2022
The interaction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) of spike protein with angiotensin-converting enzyme 2 (ACE2) mediates cell invasion.
Jerome P. L. Ng (10787800), Paolo Coghi (5476505), Maurizio Memo (336010), Xiao Yun Yun (12296301), Betty Yuan Kwan Law (12296304), Vincent Kam Wai Wong (6068207), Alessandra Gianoncelli (1483294), Giovanni Ribaudo (2892179)   +7 more
core   +2 more sources

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, Volume 13, Issue 51, 14 September 2026.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Metabolomics and DNA-Based Authentication of Two Traditional Asian Medicinal and Aromatic Species of Salvia subg. Perovskia

Cells, 2021
Subgenus Perovskia of the extended genus of Salvia comprises several Central Asian medicinal and aromatic species, of which S. yangii and S. abrotanoides are the most widespread.
Monika Bielecka, Bartosz Pencakowski, Marta Stafiniak, Klemens Jakubowski, Mehdi Rahimmalek, Shima Gharibi, Adam Matkowski, Sylwester Ślusarczyk   +7 more
doaj   +1 more source

Novel Diterpenoids From Salvia rosmarinus Reveal a Compound With Antiproliferative and Antioxidant Activities

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Four novel diterpenoids were isolated from Salvia rosmarinus (rosemary), together with nine known compounds. ECD calculations were employed to establish the absolute configuration of diterpenoids 1 and 2. The 18‐hydroxycarnosol (1) was evaluated as antiproliferative (SRB assay) and antioxidant (DPPH and TBARS), showing promising results.
Diana Pérez‐Juanchi, Celia Bustos‐Brito, Ma. Teresa Ramírez‐Apan, Antonio Nieto‐Camacho, Leovigildo Quijano, Baldomero Esquivel   +5 more
wiley   +1 more source

Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis. [PDF]

PLoS ONE, 2013
Salvia miltiorrhiza Bunge, a perennial plant of Lamiaceae, accumulates abietane-type diterpenoids of tanshinones in root, which have been used as traditional Chinese medicine to treat neuroasthenic insomnia and cardiovascular diseases.
Lei Yang, Guohui Ding, Haiyan Lin, Haining Cheng, Yu Kong, Yukun Wei, Xin Fang, Renyi Liu, Lingiian Wang, Xiaoya Chen, Changqing Yang   +10 more
doaj   +1 more source

Bushen Huatan Formula Ameliorates Early Chronic Low‐Grade Inflammation in Obese PCOS Via the TLR4/NF‐κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This study used an integrated network pharmacology and experimental strategy to investigate how Bushen Huatan Formula (BHF) mitigates early‐stage chronic low‐grade inflammation in obese polycystic ovary syndrome (PCOS). Methods Candidate components and targets of BHF were retrieved from the TCMSP database, and protein–protein ...
Jianing Zhang, Fangyun Gu, Yunyun Li, Xiaoling Feng, Hongying Kuang, Fang Xu, Miao Sun   +6 more
wiley   +1 more source

Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza

Frontiers in Plant Science, 2021
Salvia miltiorrhiza Bunge is a common Chinese herbal medicine, and its major active ingredients are phenolic acids and tanshinones, which are widely used to treat vascular diseases. However, the wild form of S.
Sijia Wu, Bo Zhu, Luping Qin, Khalid Rahman, Lei Zhang, Ting Han   +5 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Alcoholic extracts of Russian sage (Salvia yangii) contain bioactive terpenoids with inhibitory activity against grapevine downy mildew (Plasmopara viticola)

Pest Management Science, Volume 82, Issue 9, Page 8159-8170, September 2026.
Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone, Oscar Giovannini, Martina Magni, Michael Oberhuber, Peter Robatscher, Michele Perazzolli   +5 more
wiley   +1 more source

Tanshinones Inhibit Amyloid Aggregation by Amyloid‑β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells

, 2016
The misfolding and aggregation of amyloid-β (Aβ) peptides into amyloid fibrils is regarded as one of the causative events in the pathogenesis of Alzheimer’s disease (AD).
Qiuming Wang (1521106), Rundong Hu (1605529), Steven Chuang (1690606), Ge Zhang (112487), Xiang Yu (70326), Kunal Patal (1945345), Jie Zheng (31208)   +6 more
core   +1 more source