Results 51 to 60 of about 2,991 (214)

Towards elucidating carnosic acid biosynthesis in Lamiaceae: Functional characterization of the three first steps of the pathway in Salvia fruticosa and Rosmarinus officinalis [PDF]

, 2015
Carnosic acid (CA) is a phenolic diterpene with anti-tumour, anti-diabetic, antibacterial and neuroprotective properties that is produced by a number of species from several genera of the Lamiaceae family, including Salvia fruticosa (Cretan sage) and ...
Božić, Dragana, Brückner, Kathleen, Chatzopoulou, Fani M., De Vos, Ric C.H., Dimitriadou, Eleni, Ferrer i Prats, Albert, Kampranis, Sotirios C., Kanellis, Angelos K., Katsarou, Dimitra, Kostas, Stefanos, Makris, Antonios M., Manzano Alías, David, Papaefthimiou, Dimitra, Papanikolaou, Antigoni, Pateraki, Irene, Scheler, Ulschan, Tissier, Alain, Tsoleridis, Constantinos A.   +17 more
core   +5 more sources

Tanshinone IIA: A Promising Natural Cardioprotective Agent [PDF]

Evidence-Based Complementary and Alternative Medicine, 2012
Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root ofSalvia miltiorrhizaBunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions.
Shang, Qinghua, Xu, Hao, Huang, Li
openaire   +2 more sources

Molecular Mechanisms of Cardioprotective Actions of Tanshinones

Journal of Chemistry, 2016
Tanshinones are lipophilic compounds derived from Salvia miltiorrhiza (Danshen) that has been widely used to treat coronary heart diseases in China. The cardioprotective actions of tanshinones have been extensively studied in various models of myocardial
Hyou-Ju Jin, Chun-Guang Li
doaj   +1 more source

Flavoenzyme-mediated reduction reactions and antitumor activity of nitrogen-containing tetracyclic ortho-quinone compounds and their nitrated derivatives [PDF]

, 2017
Nitrogen-based tetracyclic ortho-quinones (naphtho[1'2':4.5]imidazo[1,2-a]pyridine-5,6-diones, NPDOs) and their nitro-substituted derivatives (nitro-(P)NPDOs) were obtained by condensation of substituted 2,3-dichloro- 1,4-naphthoquinones with 2-amino ...
Anusevičius, Žilvinas, Krikštopaitis, Kastis, Marozienė, Audronė, Misevičienė, Lina, Pečiukaitytė-Alksnė, Milda, Staniulytė, Zita, Čėnas, Narimantas, Šarlauskas, Jonas   +7 more
core   +1 more source

Exploring plant tissue culture to improve the production of phenolic compounds: a review [PDF]

, 2016
Plant tissue and organ culture has been extensively used from the beginning of the XX century for the study and comprehension of some primary biological mechanisms such as morphogenesis.
Alves, Rita C., Dias, Maria Inês, Ferreira, Isabel C.F.R., Sousa, Maria João   +3 more
core   +1 more source

Anticancer Effect of Tanshinones on Female Breast Cancer and Gynecological Cancer

Frontiers in Pharmacology, 2022
Female breast cancer, ovarian cancer, cervical cancer, and endometrial cancer are the most common tumors and the most common causes of cancer-related mortality worldwide in women.
Zhou Jin, Zhou Jin, Yu Chenghao, Peng Cheng, Peng Cheng, Peng Cheng   +5 more
doaj   +1 more source

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism [PDF]

, 2014
Diseases of failed inflammation resolution are common and largely incurable. Therapeutic induction of inflammation resolution is an attractive strategy to bring about healing without increasing susceptibility to infection.
Anderson, S.R., Bojarczuk, A.N., Burgon, J., Chimen, M., Coles, M.C., Farrow, S.N., Hamza, B., Holmes, G.R., Irimia, D., Jones, S., Kadirkamanathan, V., Loynes, C.A., Prince, L.R., Rainger, G.E., Renshaw, S.A., Robertson, A.L., Sawtell, A.K., Solari, R., Walmsley, S.R., Whyte, M.K.B., Willson, J.   +20 more
core   +1 more source

Mass Spectrometry Imaging‐Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa

Advanced Science, EarlyView.
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu, Wenna Duan, Weiwei Tang, Yucheng Zhao, Bin Li   +4 more
wiley   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

Biomolecules, 2022
Tanshinone IIA (TIIA) and cryptotanshinone (CRY) from Salvia miltiorrhiza Bunge were investigated for their inhibitory activity against the cyclooxygenase-2 (COX-2)/microsomal prostaglandin E synthase-1 (mPGES-1)/endothelial prostaglandin 3 (EP3) pathway
Anella Saviano, Simona De Vita, Maria Giovanna Chini, Noemi Marigliano, Gianluigi Lauro, Gian Marco Casillo, Federica Raucci, Maria Iorizzi, Robert Klaus Hofstetter, Katrin Fischer, Andreas Koeberle, Oliver Werz, Francesco Maione, Giuseppe Bifulco   +13 more
doaj   +1 more source