Results 71 to 80 of about 2,991 (214)
Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy [PDF]
, 2014 published_or_final_versio
CHEUNG, F +7 more
core +3 more sources
Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy
Advanced Science, Volume 13, Issue 21, 13 April 2026.Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu +6 more
wiley +1 more source
Biomedicine & Pharmacotherapy, 2020 Drug development has long included the systematic exploration of various resources. Among these, natural products are one of the most important resources from which novel agents are developed due to the multiple pharmacologic effects of these natural products on diseases. Tanshinone, a representative natural product, is the main compound extracted from
Zhibei, Li +3 more
openaire +2 more sources
Frontiers in Plant Science, 2018 Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of cardiovascular diseases. WRKYs play important roles in plant metabolism, but their regulation mechanism in Salvia miltiorrhiza remains elusive.
Wenzhi Cao +8 more
doaj +1 more source
Archiv der Pharmazie, Volume 359, Issue 4, April 2026.New sulfonamide‐Schiff bases were synthesized, characterized, and investigated for their cytotoxic, antioxidant, HDAC, and apoptotic activities in human colon cancer cells (DLD‐1 and HT‐29). Compounds 3c and 3d emerged as promising candidates to act as selective therapeutic agents by targeting the p38/MAPK‐ERK1 pathway in colorectal cancer.
Seda Mesci +5 more
wiley +1 more source
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors [PDF]
, 2018 The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target.
Baj, Vanessa +18 more
core +2 more sources
Cancer Innovation, Volume 5, Issue 2, April 2026.Chimeric antigen receptor (CAR) T‐cell therapy, although revolutionary for haematological malignancies, faces significant challenges, including T‐cell exhaustion, limited persistence, and treatment‐related toxicity. The integration of small‐molecule compounds offers a promising strategy to overcome these limitations.
Rangzi Yi +3 more
wiley +1 more source
Correlations between SmCPS1 promoter polymorphism and tanshinone contents in Salvia miltiorrhiza
Czech Journal of Genetics and Plant Breeding, 2018 Copalyl diphosphate synthase 1 (SmCPS1) is the first committed enzyme in tanshinone biosynthesis. The promoter region plays an important role in the transcriptional regulation of genes.
Ying SUN +5 more
doaj +1 more source
Deubiquitylating Enzymes and DNA Damage Response Pathways [PDF]
, 2013 Covalent post-translational modification of proteins by ubiquitin and ubiquitin-like factors has emerged as a general mechanism to regulate myriad intra-cellular processes. The addition and removal of ubiquitin or ubiquitin-like proteins from factors has
Mark Kemp +3 more
core +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.ZYSD exerts curative and preventive cardioprotection against isoproterenol‐induced myocardial infarction through synergistic interaction with probiotics, exerting antioxidant and anti‐inflammatory effects. ABSTRACT Zhenyuan Solid Drink (ZYSD) is a formulation consisting of 6 medicinal herbs that can be used as both food and medicinal materials in China.
Jiawen Huang +11 more
wiley +1 more source