Results 81 to 90 of about 2,991 (214)

Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake [PDF]

Biochemical Pharmacology, 2012
Our seminal discovery of high mobility group box 1 (HMGB1) as a late mediator of lethal systemic inflammation has prompted a new field of investigation for the development of experimental therapeutics. We previously reported that a major Danshen ingredient, tanshinone IIA sodium sulfonate (TSN-SS), selectively inhibited endotoxin-induced HMGB1 release ...
Yusong, Zhang, Wei, Li, Shu, Zhu, Arvin, Jundoria, Jianhua, Li, Huan, Yang, Saijun, Fan, Ping, Wang, Kevin J, Tracey, Andrew E, Sama, Haichao, Wang   +10 more
openaire   +2 more sources

Equality-evaluation of Wakan-yaku (Japanese-Chinese traditional medicines) with liquid chromatography-mass spectrometry (LC-MS) : comparison of constituents of original plants for Chinese traditional medicine "Dan-shen (Tan-j in)" [PDF]

, 2001
Wakan-yaku (Japanese-Chinese traditional medicines) are natural products and its constituents and/or activities depend on several factors, such as species, timing of collection, producing area, individual, etc.
Tezuka Yasuhiro
core   +1 more source

Danshensu Ethyl Ester Induces Ferroptosis Through Targeted Inhibition of SLC7A11 Transport Function in NSCLC

Thoracic Cancer, Volume 17, Issue 8, April 2026.
Danshensu ethyl ester (DEE) promotes ferroptosis by targeting and inhibiting the transport function of SLC7A11, independent of the p53 pathway, thereby inhibiting NSCLC. DEE reduces intracellular cysteine and glutathione (GSH) levels, while increasing reactive oxygen species (ROS) and malondialdehyde (MDA), thereby triggering ferroptosis.
Rui Yan, Sen Xu, Meng Yan, Dongyang Wu, Jingwen Zhang, Chunsheng Zhang, Jiale Liu, You‐Jie Li, Jiankai Feng, Gui‐Wu Qu, Shu‐Yang Xie   +10 more
wiley   +1 more source

Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion

Frontiers in Bioscience, 2012
Tanshinone IIA (Tan IIA), an active component derived from Salvia miltiorrhiza root, has been used to treat various ischemic cardiovascular and cerebrovascular diseases. However, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. Here, we addressed this issue by using a 90-minute partial liver ischemia model.
Yan-yan, Qi, Liang, Xiao, Lu-ding, Zhang, Shao-hua, Song, Yi, Mei, Teng, Chen, Jian-ming, Tang, Fang, Liu, Guo-shan, Ding, Yong-zhao, Shi, Quan-xing, Wang   +10 more
openaire   +2 more sources

Transcriptome and yeast two-hybrid sequencing shed light on the crosstalk between light and jasmonate signaling in regulating tanshinone biosynthesis

Medicinal Plant Biology
As a high-value active component in Salvia miltiorrhiza (Danshen), the accumulation of tanshinones is under the influence of various environmental factors, yet it is unknown whether light, as an essential environmental factor for plant growth, regulates ...
Han Zheng, Xueqing Fu, Muyao Yu, Qi Liu, Chenyi Li, Ling Li, Shuyi Qian, Kang Chen, Shuncang Zhang, Kexuan Tang, Luqi Huang   +10 more
doaj   +1 more source

Production of Salvianolic Acid B in Roots of Salvia miltiorrhiza (Danshen) During the Post-Harvest Drying Process

Molecules, 2012
Drying is the most common and fundamental procedure in the post-harvest processing which contributes to the quality and valuation of medicinal plants. However, attention to and research work on this aspect is relatively poor.
Guo-Jun Zhou, Xiao-Mei Xie, Tong-Shui Zhou, Xiao-Bing Li, Yan Li, Wei Wang   +5 more
doaj   +1 more source

Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis. [PDF]

PLoS ONE, 2013
Salvia miltiorrhiza Bunge, a perennial plant of Lamiaceae, accumulates abietane-type diterpenoids of tanshinones in root, which have been used as traditional Chinese medicine to treat neuroasthenic insomnia and cardiovascular diseases.
Lei Yang, Guohui Ding, Haiyan Lin, Haining Cheng, Yu Kong, Yukun Wei, Xin Fang, Renyi Liu, Lingiian Wang, Xiaoya Chen, Changqing Yang   +10 more
doaj   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, Volume 59, Issue 4, April 2026.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat

European Journal of Pharmaceutical Sciences, 2007
Tanshinone II(A) and cryptotanshinone are the main pharmacologically active components in the Chinese herb drug Salvia miltiorrhiza Bge. The objective of this study was to investigate the effect of coexisting tanshinones in liposoluble ethanol extract of S. miltiorrhiza Bge.
Min, Song, Tai-Jun, Hang, Zhengxing, Zhang, Hong-Yuan, Chen   +3 more
openaire   +2 more sources

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source