Results 81 to 90 of about 2,182 (156)

The inhibition of SARS-CoV-2 Papain-like protease by tanshinones [PDF]

The emergence of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has highlighted the critical need for effective antiviral treatments. Three significant coronaviruses—SARS-CoV-1, MERS-CoV, and SARS-CoV-2—have posed serious global health ...
Beringer, Alex
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Biosynthesis of bioactive ingredients of Salvia miltiorrhiza and advanced biotechnologies for their production

Biotechnology & Biotechnological Equipment, 2018
This review deals with the progress in the biosynthesis and regulation of tanshinones and salvianolic acids as well as the prospects and challenges for producing such compounds through biotechnology techniques.
Yingpeng Xu, Lijun Geng, Shujuan Zhao
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Abstract 5682: Tanshinones in Salvia miltiorrhiza as potential chemopreventive agents against lung cancer

, 2010
The search for effective regimens with minimal adverse effects for the prevention and treatment of lung cancer remains the top priority research to eradicate this devastating disease.
Linglin Li, Yanli Li, Jin-Rong Zhou, Yi Gong   +3 more
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Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice

, 2003
Tanshinones are the major lipid soluble pharmacological constituents of Danshen, the dried roots of Salvia miltiorrhiza Bunge (Labiatae), a well known traditional Chinese medicine used for the treatment of cerebrovascular diseases including stroke ...
Sucher, NJ, Lam, BYH, Chung, SK, Luo, HW, Sun, X., Sun, X, Lo, ACY   +6 more
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Tanshinones from Chinese Medicinal Herb Danshen (Salvia miltiorrhiza Bunge) Suppress Prostate Cancer Growth and Androgen Receptor Signaling

, 2012
To test whether tanshinones inhibit prostate cancer (PCa) growth at least in part through inhibiting androgen receptor (AR) signaling. We evaluated cell growth, survival and AR signaling parameters of PCa cells after exposure to tanshinones in models.
Soo-Jin Jeong, Jiang, Cheng, Jinhui Zhang, Min Ye, Cheng Jiang, Suk-Hyun Won, Lu, Junxuan, Kim, Sung-Hoon, Yong Zhang, Hyo-Jeong Lee, Ye, Min, Lee, Eun-Ok, Sung-Hoon Kim, Lee, Hyo-Jeong, Won, Suk-Hyun, Eun-Ok Lee, Zhang, Jinhui, Jeong, Soo-Jin, Junxuan Lü, Zhang, Yong   +19 more
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Overexpression of SmbHLH148 induced biosynthesis of tanshinones as well as phenolic acids in Salvia miltiorrhiza hairy roots

, 2018
Phenolic acids and tanshinones are the two important groups of pharmaceutical ingredients presented in Salvia miltiorrhiza Bunge. The bHLH transcription factors could regulate secondary metabolism efficiently in plants.
Kaijing Yan, Zongsuo Liang, Bingcong Xing, Zhuoni Hou, Xuemin Zhang, Dongfeng Yang, Lin Liu, Lijun Liang   +7 more
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Polysaccharide Fraction Extracted from Endophytic Fungus Trichoderma atroviride D16 Has an Influence on the Proteomics Profile of the Salvia miltiorrhiza Hairy Roots

Biomolecules, 2019
Trichoderma atroviride develops a symbiont relationship with Salvia miltiorrhiza and this association involves a number of signaling pathways and proteomic responses between both partners.
Wei Peng, Qian-liang Ming, Xin Zhai, Qing Zhang, Khalid Rahman, Si-jia Wu, Lu-ping Qin, Ting Han   +7 more
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ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide [PDF]

, 2011
The tanshinone natural products possess a variety of pharmacological properties including anti-bacterial, anti-inflammatory, anti-oxidant, and anti-neoplastic activity. The molecular basis of these effects, however, remains largely unknown.
Kuo-Hsiung Lee, Wang, Xihong, Jarstfer, Michael B., Michael B. Jarstfer, Lee, Kuo Hsiung, Joana Soares, Soares, Joana, Brian R. Keppler, Xihong Wang, Keppler, Brian R.   +9 more
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Tanshinones inhibit hIAPP aggregation, disaggregate preformed hIAPP fibrils, and protect cultured cells

, 2018
Tanshinones act as common inhibitors to inhibit the aggregation of both hIAPP and Aβ, disaggregate preformed hIAPP and Aβ amyloid fibrils, and protect cells from hIAPP- and Aβ-induced toxicity.
Mingzhen Zhang, Guizhao Liang, Jianxiong Xu, Baiping Ren, Yan Sun, Yonglan Liu, Yanxian Zhang, Jie Zheng   +7 more
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Magnesium Hydride Enhances Both Growth and Bioactive Compound Biosynthesis in Salvia miltiorrhiza: A Novel Eco-Friendly Approach for Medicinal Plant Cultivation

Horticulturae
Medicinal plants have garnered widespread attention owing to their broad range of biological activities and pharmaceutical value. However, achieving a balance between promoting plant growth and enhancing bioactive compound accumulation remains a major ...
Wei Li, Youran Zeng, Jingjing Li, Xinru Du, Yang Liu, Yihong Li, Haiyan Yang, Gurusamy Abirami, Itezaz Younas, Han Zheng, Dongfeng Yang   +10 more
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