Cryptotanshinone targets the bacterial membrane and inhibits methicillin-resistant Staphylococcus aureus [PDF]
AMB ExpressThe widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has become a major public health concern worldwide, highlighting the urgent need for innovative antimicrobial agents with specific efficacy against MRSA.
Qingyu Liu +9 more
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Effects of cryptotanshinone in treatment of polycystic ovary syndrome in rats: a systematic review and meta-analysis [PDF]
Frontiers in PharmacologyBackgroundPCOS is a prevalent endocrine disorder characterized by metabolic dysfunctions, including insulin resistance and hyperandrogenism. Cryptotanshinone, a bioactive compound, has shown promise in addressing reproductive abnormalities.
Pingping Su +4 more
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Anticancer potential of Dendrocnide meyeniana through phytochemical profiling, ADMET analysis, molecular docking, and in silico cytotoxicity evaluation [PDF]
Scientific ReportsPhytochemicals are widely explored for cancer therapeutics due to their structural diversity and broad pharmacological activities. This study investigated the phytochemical composition and anticancer potential of Dendrocnide meyeniana using integrated in
Edlyn E. Pooten +5 more
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Asian Journal of Pharmaceutical Sciences, 2017 Total tanshinones are lipophilic active constituents extracted from Salvia miltiorrhiza Bge. Tanshinone IIA and cryptotanshinone are the major components in total tanshinones.
Xifeng Zhai +2 more
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Exploring the therapeutic potency of cryptotanshinone in cervical cancer: a multi-omics and network pharmacology approach [PDF]
Frontiers in GeneticsIntroductionCervical cancer remains a significant challenge in oncology with an escalating demand for novel therapeutic strategies that can navigate the complexities of its pathophysiology.
Zenghong Lu +6 more
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Validation of Madecassoside Synergy Significantly Enhanced Cryptotanshinone’s Therapeutic Efficacy Against Acne Vulgaris [PDF]
BioengineeringCurrent acne therapies face major limitations, including antibiotic resistance and skin irritancy. In this study, a synergistic strategy combining cryptotanshinone and madecassoside was developed through functional complementarity. Antibacterial activity
Yaling Guo +5 more
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Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Cryptotanshinone Against Platelet Aggregation [PDF]
Current Issues in Molecular BiologyCryptotanshinone (CTS), an antiplatelet compound from Salvia miltiorrhiza, exhibits in vitro potency comparable to aspirin. This study integrated network pharmacology and metabolomics to elucidate its underlying mechanisms.
Jielan Huang +13 more
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Blood biochemical landscape and new insights into clinical decision-making for polycystic ovary syndrome in Chinese women: a prospective cohort study [PDF]
Frontiers in EndocrinologyIntroductionThe Polycystic ovary syndrome (PCOS), a prevalent endocrine disorder affecting women’s reproductive and metabolic health, faces diagnostic challenges due to heterogeneous clinical presentations and the absence of reliable biomarkers.
Yutong Li +7 more
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Molecular Therapy - Nucleic Acids, 2018 Cryptotanshinone (CTS) has emerged as an anti-inflammatory agent in osteoarthritis (OA). However, the molecular mechanism underlying its potent therapeutic effect on OA remains largely unknown.
Xiaojie Xu, Lei Kang, Stuart B Goodman
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Cryptotanshinone Suppresses BVDV Propagation by Suppressing Cell Apoptosis and Restoring Hormone Secretion in Bovine Granulosa Cells [PDF]
VirusesBovine viral diarrhea virus (BVDV) constitutes a significant pathogen adversely threatening reproductive performance in the cattle industry, primarily by inducing ovarian dysfunction characterized by aberrant hormone synthesis and impaired follicular ...
Xiaoliang Chen +11 more
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