Results 1 to 10 of about 4,552 (200)

Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats

Asian Pacific Journal of Tropical Biomedicine, 2023
Objective: To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in rats. Methods: Rats were administered with cladribine (1 mg/kg, p.o.) and cryptotanshinone (10 and 20 mg/kg, i.p.) for four weeks ...
Khadga Raj Aran, G D Gupta, Shamsher Singh   +2 more
doaj   +3 more sources

Effects of cryptotanshinone in treatment of polycystic ovary syndrome in rats: a systematic review and meta-analysis [PDF]

Frontiers in Pharmacology
BackgroundPCOS is a prevalent endocrine disorder characterized by metabolic dysfunctions, including insulin resistance and hyperandrogenism. Cryptotanshinone, a bioactive compound, has shown promise in addressing reproductive abnormalities.
Pingping Su, Xv Wang, Ruoqian Cai, Chang Yan, Yun Sun   +4 more
doaj   +4 more sources

Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones [PDF]

Asian Journal of Pharmaceutical Sciences, 2017
Total tanshinones are lipophilic active constituents extracted from Salvia miltiorrhiza Bge. Tanshinone IIA and cryptotanshinone are the major components in total tanshinones.
Charlie Xue, George Binh Lenon, Xifeng Zhai   +2 more
exaly   +4 more sources

Compound Abrus cantoniensis Extract Alleviates AFB₁-Induced Liver Injury by Regulating PI3K-AKT Pathway and Gut Microbiota/Butyrate Metabolism. [PDF]

Adv Sci (Weinh)
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hu H, Cheng M, Zheng S, Liu H, Wei X, Yang W, Yang H, Yuan L, Jiang L, Chen J, Zhao L, Guo Y, Si H.   +12 more
europepmc   +2 more sources

Cryptotanshinone targets the bacterial membrane and inhibits methicillin-resistant Staphylococcus aureus [PDF]

AMB Express
The widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has become a major public health concern worldwide, highlighting the urgent need for innovative antimicrobial agents with specific efficacy against MRSA.
Qingyu Liu, Yongxue Tang, Siyu Wang, Chao Wang, Ping Tan, Xiaomei Wang, Hui Zhou, Huibin Zhu, Xiaobing Xie, Xingwang Ning   +9 more
doaj   +2 more sources

Cardiovascular Benefits of <i>Salvia miltiorrhiza</i> (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care. [PDF]

Food Sci Nutr
Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Vikal A, Maurya R, Patel P, Kurmi BD, Setzer WN, Sharifi-Rad J, Calina D.   +6 more
europepmc   +2 more sources

Cross-stage single-cell and spatial metabolome analyses reveal periderm specialization and tanshinone biosynthesis in Salvia miltiorrhiza roots. [PDF]

New Phytol
Biosynthesis and accumulation of tanshinones in the periderm of Salvia miltiorrhiza during secondary root growth. Summary Perennial herbs develop long‐lived roots that undergo repeated cycles of secondary growth, during which the periderm functions as a protective barrier and a major site of specialized metabolite accumulation.
Liu L, Gao L, Wang ZY, Liu Y, Ju H, Lin H, Shi Z, Cai WJ, Li X, Huang YB, Kong Y, Xu JJ, Chen HP, Fang X, Guo J, Hu YH, Chen K, Chen XY, Hao J, Yang L.   +19 more
europepmc   +2 more sources

Anticancer potential of Dendrocnide meyeniana through phytochemical profiling, ADMET analysis, molecular docking, and in silico cytotoxicity evaluation [PDF]

Scientific Reports
Phytochemicals are widely explored for cancer therapeutics due to their structural diversity and broad pharmacological activities. This study investigated the phytochemical composition and anticancer potential of Dendrocnide meyeniana using integrated in
Edlyn E. Pooten, Khristina G. Judan Cruz, Evaristo A. Abella, Anna Karen C. Laserna, Abul Baskhar Mir Md. Khademul Islam, Kozo Watanabe   +5 more
doaj   +2 more sources

Blood biochemical landscape and new insights into clinical decision-making for polycystic ovary syndrome in Chinese women: a prospective cohort study [PDF]

Frontiers in Endocrinology
IntroductionThe Polycystic ovary syndrome (PCOS), a prevalent endocrine disorder affecting women’s reproductive and metabolic health, faces diagnostic challenges due to heterogeneous clinical presentations and the absence of reliable biomarkers.
Yutong Li, Yutong Li, Xiufeng Lin, Ke Zou, Jing Du, Qingni Li, Linkun Zhong, Shan Jiang   +7 more
doaj   +2 more sources

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Cryptotanshinone Against Platelet Aggregation [PDF]

Current Issues in Molecular Biology
Cryptotanshinone (CTS), an antiplatelet compound from Salvia miltiorrhiza, exhibits in vitro potency comparable to aspirin. This study integrated network pharmacology and metabolomics to elucidate its underlying mechanisms.
Jielan Huang, Zhenjie Liu, Baolin Wang, Haixin Qiu, Qiujie Chen, Jinyan Xian, Shen Liu, Xiaoxiu Shi, Ting Xia, Xiaoqing Tan, Wenhui Jiang, Yuanle Shen, Liuping Wang, Jianfang Feng   +13 more
doaj   +2 more sources