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Pharmacological Mechanisms of Cryptotanshinone: Recent Advances in Cardiovascular, Cancer, and Neurological Disease Applications [PDF]
Drug Design, Development and TherapyZiyao Zheng,1 Liyuan Ke,1 Shumin Ye,1 Peiying Shi,2 Hong Yao1,3 1Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, People’s Republic of China; 2Department of Traditional Chinese Medicine Resource and ...
Zheng Z, Ke L, Ye S, Shi P, Yao H
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Nanomaterials, 2014 Heat dissipation by magnetic nanoparticles (MNPs) under an alternating magnetic field can be used to selectively treat cancer tissues. Antibodies conjugated to MNPs can enhance the therapeutic effects of hyperthermia by altering antibody-antigen ...
Satoshi Ota +4 more
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Cryptotanshinone-Induced Permeabilization of Model Phospholipid Membranes: A Biophysical Study
MembranesThe Danshen terpenoid cryptotanshinone (CPT) is gaining enormous interest in light of its various outstanding biological activities. Among those, CPT has been shown to interact with cell membranes and, for instance, to have antibacterial activity ...
Julia Ortiz +3 more
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Natural Product Communications, 2022 Cryptotanshinone is a quinone diterpene extracted from the traditional Chinese medicine Salvia miltiorrhiza root that shows obvious anticancer activity.
Wenkai Wu +8 more
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Developmental toxicity of cryptotanshinone on the early-life stage of zebrafish development [PDF]
Human & Experimental Toxicology, 2021 Cryptotanshinone (Cry) has multiple potential functions in treating different diseases. Most studies on Cry focus on its pharmacological effects and mechanisms, but toxicological reports on Cry are rare. Zebrafish is used as a model organism in drug development as it saves costs and time. This work aimed to investigate the toxicity of Cry on zebrafish.
C Wang +8 more
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Frontiers in Pharmacology, 2022 Cryptotanshinone (CTS) is a lipophilic constituent of Salvia miltiorrhiza, with a broad-spectrum anticancer activity. We have observed that CTS enhances the efficacy of gefitinib in human lung cancer H1975 cells, yet little is known about its molecular ...
Peiheng Cai +6 more
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Cryptotanshinone ameliorates CUS-induced depressive-like behaviors in mice [PDF]
Translational Neuroscience, 2021 Abstract Objectives Cryptotanshinone (CPT), a natural quinoid diterpene, isolated from Salvia miltiorrhiza, has shown various pharmacological properties. However, its effect on chronic unpredictable stress (CUS)-induced depression phenotypes and the underlying mechanism remain unclear.
Wang Kaixin +14 more
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Nitrogen Fertilization Improves Growth and Bioactive Compound Content for Salvia miltiorrhiza Bunge
Horticulturae, 2023 Salvia miltiorrhiza B., an herb used in traditional Chinese medicine, has been widely used to prevent and treat cardiovascular and other diseases. Currently, the majority of medicinal plants used in the US are imported from foreign countries, which ...
Zhiheng Xing +4 more
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Total Syntheses of Tanshinone-I, Tanshinone-II and Cryptotanshinone [PDF]
Bulletin of the Chemical Society of Japan, 1968 Abstract Total syntheses of tanshinone-II (II) and cryptotanshinone (III) from 3-methylbenzofuran-4, 7-quinone (X) and 6,6-dimethyl-l-vinylcyclohexene (IX), and of tanshinone-I (I) from quinone X and o-methylstyrene (XVIII) are described. Preliminary accounts for the Diels-Alder reaction of methoxybenzoquinone revealed that the effect of
Hiroshi Kakisawa, Yoshinobu Inouye
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Frontiers in Pharmacology, 2021 Among cancers, colorectal cancer (CRC) has one of the highest annual incidence and death rates. Considering severe adverse reactions associated with classical chemotherapy medications, traditional Chinese medicines have become potential drug candidates ...
Xiaojing Fu +5 more
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