Results 41 to 50 of about 5,330 (211)

Cryptotanshinone Attenuates Inflammatory Response of Microglial Cells via the Nrf2/HO-1 Pathway

Frontiers in Neuroscience, 2019
Cryptotanshinone (CTN), a monomer compound extracted from the dried roots and rhizomes of Salvia miltiorrhiza Bge, has a variety of pharmacological effects.
Yang Zhou, Yang Zhou, Yang Zhou, Xiao Wang, Weihai Ying, Danhong Wu, Ping Zhong   +6 more
doaj   +1 more source

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism [PDF]

, 2014
Diseases of failed inflammation resolution are common and largely incurable. Therapeutic induction of inflammation resolution is an attractive strategy to bring about healing without increasing susceptibility to infection.
Anderson, S.R., Bojarczuk, A.N., Burgon, J., Chimen, M., Coles, M.C., Farrow, S.N., Hamza, B., Holmes, G.R., Irimia, D., Jones, S., Kadirkamanathan, V., Loynes, C.A., Prince, L.R., Rainger, G.E., Renshaw, S.A., Robertson, A.L., Sawtell, A.K., Solari, R., Walmsley, S.R., Whyte, M.K.B., Willson, J.   +20 more
core   +1 more source

Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases

Frontiers in Pharmacology, 2022
Cryptotanshinone (CTS), a diterpenoid quinone, is found mostly in Salvia miltiorrhiza Bunge (S. miltiorrhiza) and plays a crucial role in many cellular processes, such as cell proliferation/self-renewal, differentiation and apoptosis.
Xiaomeng Guo, Ruishuang Ma, Meng Wang, Benson Wui-Man Lau, Xiaopeng Chen, Yue Li   +5 more
doaj   +1 more source

Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish

Frontiers in Pharmacology, 2021
Thrombosis is a key pathological event in cardiovascular diseases, and is also the most important targeting process for their clinical management. New drug development in thrombosis treatment is still in great demand. According to the traditional Chinese
Jun Li, Hao Liu, Zhenzhong Yang, Qingqing Yu, Lu Zhao, Yi Wang, Yi Wang   +6 more
doaj   +1 more source

Combining Metabolomics and Transcriptomics to Characterize Tanshinone Biosynthesis in Salvia Miltiorrhiza [PDF]

, 2014
Plant natural products have been co-opted for millennia by humans for various uses such as flavor, fragrances, and medicines. These compounds often are only produced in relatively low amounts and are difficult to chemically synthesize, limiting access ...
Cui, Guanghong, Gao, Wei, Hillwig, Matthew L, Huang, Luqi, Jackson, Alana, Peters, Reuben J, Shen, Ye, Sun, Hai-Xi, Wang, Xiao, Wang, Xiu-Jie, Xiao, Hongbin, Zhang, Liangxiao, Zhao, Nan   +12 more
core   +3 more sources

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit

Frontiers in Neurology, 2019
Cryptotanshinone (CTs), an active component isolated from the root of Salvia miltiorrhiza (SM), has been shown to exert potent neuroprotective property.
Hongye Zhao, Hongye Zhao, Tiezheng Zheng, Xiaohan Yang, Ming Fan, Lingling Zhu, Shuhong Liu, Liying Wu, Changkai Sun, Changkai Sun   +9 more
doaj   +1 more source

Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs)

Pharmaceutical Biology, 2017
Contents: Danshen is a popular herb employed to treat cardiovascular and cerebrovascular diseases worldwide. Danshen–drug interaction has not been well studied.
Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang   +4 more
doaj   +1 more source

Anti-tumor effects of cryptotanshinone (C19H20O3) in human osteosarcoma cell lines

Biomedicine & Pharmacotherapy, 2022
Osteosarcoma is the most prevalent malignant bone tumor and occurs most commonly in the adolescent and young adult population. Despite the recent advances in surgeries and chemotherapy, the overall survival in patients with resectable metastases is around 20%.
Haswanth, Vundavilli, Aniruddha, Datta, Chao, Sima, Jianping, Hua, Rosana, Lopes, Michael, Bittner, Tasha, Miller, Heather M, Wilson-Robles   +7 more
openaire   +2 more sources

Quantitative Determination and Validation of Four Ketones in Salvia miltiorrhiza Bunge Using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy

Molecules, 2020
Salvia mltiorrhiza Bunge (SMB) is native to China, whose dried root has been used as medicine. A few chromatographic- or spectrometric-based methods have already been used to analyze the lipid-soluble components in SMB.
Yuanyuan Li, Zhuoni Hou, Feng Su, Jipeng Chen, Xiaodan Zhang, Ling Xu, Dongfeng Yang, Zongsuo Liang   +7 more
doaj   +1 more source

Mechanism of Cryptotanshinone Inhibiting Proliferation of Human Breast Cancer MCF7 Cells

Zhongliu Fangzhi Yanjiu, 2023
Objective To investigate the inhibitory effect of cryptotanshinone (CPT) on human breast cancer cell MCF7 and its mechanism. Methods The survival rate of MCF7 cells was measured by MTT assay.
YANG Shuhan, WANG Yuqin, LIU Hang, XIA Lijie, LIU Suying, ZHANG Ying   +5 more
doaj   +1 more source