Results 51 to 60 of about 5,330 (211)

An in-silico study examining the induction of apoptosis by Cryptotanshinone in metastatic melanoma cell lines

BMC Cancer, 2018
Background Metastatic melanoma is an aggressive form of skin cancer that evades various anti-cancer treatments including surgery, radio-,immuno- and chemo-therapy.
Radhika S. Saraf, Aniruddha Datta, Chao Sima, Jianping Hua, Rosana Lopes, Michael Bittner   +5 more
doaj   +1 more source

Development and application of base editing systems in Salvia miltiorrhiza for precise metabolic engineering. [PDF]

Plant Biotechnol J
Plant Biotechnology Journal, Volume 23, Issue 12, Page 5619-5621, December 2025.
Yao Q, Ye Y, Liu Q, Tian Y, Xiang L, Li L, Liu H, Zhang Y, Yu M, Zheng H, Huang L.   +10 more
europepmc   +2 more sources

Cryptotanshinone inhibits ovarian tumor growth and metastasis by degrading c-Myc and attenuating the FAK signaling pathway

Frontiers in Cell and Developmental Biology, 2022
Cryptotanshinone (CT), a natural compound derived from Salvia miltiorrhiza Bunge that is also known as the traditional Chinese medicine Danshen, exhibits antitumor activity in various cancers.
Huijun Guo, Huijun Guo, Wenjing Zhang, Jiaxing Wang, Guannan Zhao, Yaohong Wang, Bing-Mei Zhu, Peixin Dong, Hidemichi Watari, Baojin Wang, Wei Li, Gabor Tigyi, Junming Yue   +12 more
doaj   +1 more source

Targeted Therapy of Acute Liver Injury via Cryptotanshinone-Loaded Biomimetic Nanoparticles Derived from Mesenchymal Stromal Cells Driven by Homing

Pharmaceutics, 2023
Acute liver injury (ALI) has the potential to compromise hepatic function rapidly, with severe cases posing a considerable threat to human health and wellbeing.
Xin Zhang, Yao Yi, Yuanyuan Jiang, Jinqiu Liao, Ruiwu Yang, Xuexue Deng, Li Zhang   +6 more
doaj   +1 more source

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production [PDF]

, 2017
Signal Transducer and Activator of Transcription 3 (STAT3) has been tied to various physiological and pathological functions, mainly as a transcription factor that translocates to the nucleus upon tyrosine phosphorylation induced by cytokine stimulation.
Ali Raza, Andrew C. Larner, Benjamini, Bigi, Capron, Claudia Mertens, Dipankar Bandyopadhyay, Erin Tracy, Gibellini, Heinz Baumann, Hibino, Jennifer Sisler, Jeremy A. Meier, Kazuaki Takabe, Kim, Kramer, Lachance, Macias, Marc Cantwell, Moonjung Hyun, Peter E. Shaw, Qureshi, Sobotta, Suzana Gispert, Sylvia Torres-Odio, Szczepanek, Tammineni, Tan, Tavecchio, Vidisha Raje, Yang   +30 more
core   +1 more source

Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury [PDF]

, 2006
Lipopolysaccharide (LPS) has been implicated as one of the major cause of Gram-negative bacteria-induced sepsis that are life-threatening syndromes occurring in intensive care unit patients. Many natural products derived from medicinal plants may contain
Chan, DKO, Fu, KHM, Lee, CL, Sit, WH, Wan, JMF   +4 more
core   +1 more source

Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells

Scientific Reports, 2023
AbstractGlioblastoma multiforme (GBM) is a complex disease to treat owing to its profound chemoresistance. Therefore, we evaluated the combined effect and therapeutic efficacy of temozolomide (TMZ), a potent alkylating agent and the current gold standard therapy for GBM, and cryptotanshinone (CTS), which inhibits glioma cell proliferation in GBM cells.
Songxian Zhu, Jingjing Guo, Li Yu, Jun Liu, Jixiang Chen, Jinxin Xin, Yuqiang Zhang, Jie Luo, Chao Duan   +8 more
openaire   +3 more sources

Cryptotanshinone Attenuates Airway Remodeling by Inhibiting Crosstalk Between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Transforming Growth Factor Beta 1 Signaling Pathways in Asthma

Frontiers in Pharmacology, 2019
The study is to investigate the effect of cryptotanshinone (CTS) on airway remodeling and the possible mechanism. Male BALB/c mice were pretreated with CTS or dexamethasone 30 min before nebulized inhalation of ovalbumin (OVA).
Chongyang Wang, Chongyang Wang, Mingyu Zheng, Mingyu Zheng, Yunho Choi, Jingzhi Jiang, Jingzhi Jiang, Li Li, Li Li, Junfeng Li, Junfeng Li, Chang Xu, Chang Xu, Zhemin Xian, Zhemin Xian, Yan Li, Yan Li, Hongmei Piao, Hongmei Piao, Liangchang Li, Liangchang Li, Guanghai Yan, Guanghai Yan   +22 more
doaj   +1 more source

Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes

Biomolecules, 2023
Inflammation of the adipose tissue contributes to the onset and progression of several chronic obesity-related diseases. The two most important lipophilic diterpenoid compounds found in the root of Salvia milthorrhiza Bunge (also called Danshen ...
Sara Carpi, Stefano Quarta, Stefano Doccini, Anella Saviano, Noemi Marigliano, Beatrice Polini, Marika Massaro, Maria Annunziata Carluccio, Nadia Calabriso, Martin Wabitsch, Filippo Maria Santorelli, Marco Cecchini, Francesco Maione, Paola Nieri, Egeria Scoditti   +14 more
doaj   +1 more source

Dual blockage of STAT3 and ERK1/2 eliminates radioresistant GBM cells. [PDF]

, 2019
Radiotherapy (RT) is the major modality for control of glioblastoma multiforme (GBM), the most aggressive brain tumor in adults with poor prognosis and low patient survival rate.
Duan, Yumei, Fan, Ming, Fragoso, Ruben C, Hu, Wenfeng, Jiang, Nian, Jing, Di, Lam, Kit S, Li, Jian Jian, Sun, Lun-Quan, Xiao, Wenwu, Xie, Bowen, Zhang, Lu   +11 more
core   +1 more source