Results 51 to 60 of about 4,552 (200)

Mechanism of Cryptotanshinone Inhibiting Proliferation of Human Breast Cancer MCF7 Cells

Zhongliu Fangzhi Yanjiu, 2023
Objective To investigate the inhibitory effect of cryptotanshinone (CPT) on human breast cancer cell MCF7 and its mechanism. Methods The survival rate of MCF7 cells was measured by MTT assay.
YANG Shuhan, WANG Yuqin, LIU Hang, XIA Lijie, LIU Suying, ZHANG Ying   +5 more
doaj   +1 more source

Abstract 5269: Cryptotanshinone activate Nrf2 expression through microRNA regulations

, 2017
Cryptotanshinone is a diterpene quinone derived from the roots of Salvia miltiorrhiza Bunge. An increasing number of studies have demonstrated that cryptotanshinone has the pharmacological activities such as anti-oxidative stress, anti-bacteria, anti ...
Rachmad A. Dongoran, Tien-Yuan Wu
core   +1 more source

Molecular mechanism of tanshinone IIA and cryptotanshinone in platelet anti-aggregating effects: an integrated study of pharmacology and computational analysis [PDF]

, 2015
Tanshinone IIA and cryptotanshinone are two pharmacologically active diterpenoids extracted from the roots of Salvia milthiorriza Bunge, a plant used in Chinese traditional medicine for the treatment of some cardiovascular and cerebrovascular disease ...
CHINI, MARIA GIOVANNA, DE FEO, Vincenzo, CANTONE, VINCENZA, Maione, Francesco, Mascolo, Nicola, BIFULCO, Giuseppe   +5 more
core   +2 more sources

Cryptotanshinone protects against adriamycin-induced mitochondrial dysfunction in cardiomyocytes [PDF]

Pharmaceutical Biology, 2015
The serious side effect of Adriamycin (ADR) is cardiomyopathy. Cryptotanshinone (CRY) is widely and safely used as antioxidant with MTD more than 5 mg/g in rats (p.o).The objective of this study is to study the protection effects of CRY against ADR-induced mitochondrial dysfunction in cardiomyocytes.The chemical administration lasted for 20 days with ...
Yanshan, Zhang, Liang, Chen, Fan, Li, Huijuan, Wang, Yunyi, Yao, Jiamei, Shu, Ming-Zhong, Ying   +6 more
openaire   +2 more sources

Cryptotanshinone inhibits ovarian tumor growth and metastasis by degrading c-Myc and attenuating the FAK signaling pathway

Frontiers in Cell and Developmental Biology, 2022
Cryptotanshinone (CT), a natural compound derived from Salvia miltiorrhiza Bunge that is also known as the traditional Chinese medicine Danshen, exhibits antitumor activity in various cancers.
Huijun Guo, Huijun Guo, Wenjing Zhang, Jiaxing Wang, Guannan Zhao, Yaohong Wang, Bing-Mei Zhu, Peixin Dong, Hidemichi Watari, Baojin Wang, Wei Li, Gabor Tigyi, Junming Yue   +12 more
doaj   +1 more source

Targeted Therapy of Acute Liver Injury via Cryptotanshinone-Loaded Biomimetic Nanoparticles Derived from Mesenchymal Stromal Cells Driven by Homing

Pharmaceutics, 2023
Acute liver injury (ALI) has the potential to compromise hepatic function rapidly, with severe cases posing a considerable threat to human health and wellbeing.
Xin Zhang, Yao Yi, Yuanyuan Jiang, Jinqiu Liao, Ruiwu Yang, Xuexue Deng, Li Zhang   +6 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Cryptotanshinone Attenuates Airway Remodeling by Inhibiting Crosstalk Between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Transforming Growth Factor Beta 1 Signaling Pathways in Asthma

Frontiers in Pharmacology, 2019
The study is to investigate the effect of cryptotanshinone (CTS) on airway remodeling and the possible mechanism. Male BALB/c mice were pretreated with CTS or dexamethasone 30 min before nebulized inhalation of ovalbumin (OVA).
Chongyang Wang, Chongyang Wang, Mingyu Zheng, Mingyu Zheng, Yunho Choi, Jingzhi Jiang, Jingzhi Jiang, Li Li, Li Li, Junfeng Li, Junfeng Li, Chang Xu, Chang Xu, Zhemin Xian, Zhemin Xian, Yan Li, Yan Li, Hongmei Piao, Hongmei Piao, Liangchang Li, Liangchang Li, Guanghai Yan, Guanghai Yan   +22 more
doaj   +1 more source

From mouth to brain: Linking periodontal and peri‐implant dysbiosis to systemic inflammation and neuropathology

Periodontology 2000, EarlyView.
Abstract Background/Aim Growing evidence suggests that imbalances occurring within the human microbiota and deregulation of the host immune response may play a significant role in the development of neurodegenerative diseases. Materials and Methods A comprehensive narrative review of the latest experimental, clinical, and epidemiological insights was ...
Emilio A. Cafferata, Frank Schwarz, Jaime Díaz‐Zúñiga, Alpdogan Kantarci   +3 more
wiley   +1 more source

Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes

Biomolecules, 2023
Inflammation of the adipose tissue contributes to the onset and progression of several chronic obesity-related diseases. The two most important lipophilic diterpenoid compounds found in the root of Salvia milthorrhiza Bunge (also called Danshen ...
Sara Carpi, Stefano Quarta, Stefano Doccini, Anella Saviano, Noemi Marigliano, Beatrice Polini, Marika Massaro, Maria Annunziata Carluccio, Nadia Calabriso, Martin Wabitsch, Filippo Maria Santorelli, Marco Cecchini, Francesco Maione, Paola Nieri, Egeria Scoditti   +14 more
doaj   +1 more source