Results 31 to 40 of about 21,115,427 (202)

Analysis and Identification of Active Compounds from Salviae miltiorrhizae Radix Toxic to HCT-116 Human Colon Cancer Cells

Applied Sciences, 2020
Colorectal cancer is one of the most frequently diagnosed cancers worldwide. The aim of the present study was to simultaneously analyze compounds of Salviae miltiorrhizae Radix (SMR) and determine their cytotoxic effects on HCT-116 human colorectal ...
Bohyung Kang, Sullim Lee, Chang-Seob Seo, Ki Sung Kang, You-Kyung Choi   +4 more
doaj   +1 more source

Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish. [PDF]

PLoS One, 2020
During inflammation, dysregulated neutrophil behaviour can play a major role in a range of chronic inflammatory diseases, for many of which current treatments are generally ineffective. Recently, specific naturally occurring tanshinones have shown promising anti-inflammatory effects by targeting neutrophils in vivo, yet such tanshinones, and moreover ...
Foulkes MJ, Tolliday FH, Henry KM, Renshaw SA, Jones S.   +4 more
europepmc   +7 more sources

Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB

Biomedicine & Pharmacotherapy, 2021
Mastitis is a common disease occurs in breast-feeding mothers, but published data are poor. This study aimed to study the effects of Tanshinones on treating mastitis.Clinical trials performed in 58 breast-feeding mothers were carried out. B-ultrasound and blood test were used to measure the size of breast mass and the change of blood cell counts.
Lili, Yang, Guanglin, Zhou, Jinghua, Liu, Jinshuang, Song, Zongyu, Zhang, Qi, Huang, Fengxiang, Wei   +6 more
openaire   +2 more sources

Development of a Self-Assembled Hydrogels Based on Carboxymethyl Chitosan and Oxidized Hyaluronic Acid Containing Tanshinone Extract Nanocrystals for Enhanced Dissolution and Acne Treatment

Pharmaceuticals, 2022
This study aimed to construct a pH-responsive nanocrystalline hydrogel drug delivery system for topical delivery of insoluble drugs based on the self-assembly behavior of carboxymethyl chitosan (CMC) and oxidized hyaluronic acid (OHA).
Xiaohan Tang, Yan Liu, Hailong Yuan, Rong Gao   +3 more
doaj   +1 more source

Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor

, 2023
Natural products provide inspiration and have proven to be the most valuable source for drug discovery. Herein, we report a scaffold hybrid strategy of Tanshinone I for the discovery of NLRP3 inflammasome inhibitors.
Hongda Sheng (14613260), Jiaming Li (543737), Zhencheng Lai (6013097), Yi Wang (32470), Sunliang Cui (1447630), Yingchao Wang (2805157)   +5 more
core   +2 more sources

Integrated Transcriptomics and Proteomics to Reveal Regulation Mechanism and Evolution of SmWRKY61 on Tanshinone Biosynthesis in Salvia miltiorrhiza and Salvia castanea

Frontiers in Plant Science, 2022
Tanshinones found in Salvia species are the main active compounds for the treatment of cardiovascular and cerebrovascular diseases, but their contents are hugely different in different species. For example, tanshinone IIA content in Salvia castanea Diels
Yue Chen, Yanting Wang, Juan Guo, Jian Yang, Xiaodan Zhang, Zixuan Wang, Ying Cheng, Zewei Du, Zhechen Qi, Yanbo Huang, Mans Dennis, Yukun Wei, Dongfeng Yang, Luqi Huang, Zongsuo Liang   +14 more
doaj   +1 more source

Cytotoxic diterpenoids from Salvia glutinosa and comparison with the tanshinone profile of danshen (Salvia miltiorrhiza)

Frontiers in Plant Science, 2023
The roots of Salvia miltiorrhiza are the source of the traditional Chinese medicine danshen and the class of tanshinones, particular quinoid nor-diterpenoids of the abietane type.
Arpine Ayvazyan, Lenard Deutsch, Lenard Deutsch, Christian Zidorn, Brigitte Kircher, Brigitte Kircher, Serhat S. Çiçek, Serhat S. Çiçek   +7 more
doaj   +1 more source

Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study [PDF]

Evidence-Based Complementary and Alternative Medicine, 2011
Tanshinone IIA (Tan IIA) and sodium tanshinone IIA sulfonate (STS) were found to have protective effects on cardiomyocyte against adriamycin‐induced damage and may be used clinically. It is unclear whether the supplementation of STS or Tan IIA would affect the anticancer activity of anthracycline.
Chan, Szu-Erh, Lai, Hung-Wen, Su, Chin-Cheng, Kuo, Shou-Jen, Chien, Su-Yu, Lin, Hui-Yi, Chen, Dar-Ren   +6 more
openaire   +2 more sources

Integrative quantitative and qualitative analysis for the quality evaluation and monitoring of Danshen medicines from different sources using HPLC-DAD and NIR combined with chemometrics

Frontiers in Plant Science, 2022
The root and rhizome of Salvia miltiorrhiza (Danshen in short) is a well-known herbal medicine used to treat cardiovascular diseases in the world. In China, the roots and rhizomes of several other Salvia species (Non-Danshen in short) are also used as ...
Qing Li, Qing Li, Luming Qi, Luming Qi, Kui Zhao, Wang Ke, Tingting Li, Lina Xia, Lina Xia   +8 more
doaj   +1 more source

Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities

Frontiers in Pharmacology, 2023
In recent years, natural polysaccharides have attracted more and more attention and research because of their value in the medicine, beauty and food fields.
Lei Luo, Juan Xue, Juan Xue, Zheng Shao, Zhang Zhou, Wenqian Tang, Jinxin Liu, Hongfei Hu, Fan Yang   +8 more
doaj   +1 more source