Results 51 to 60 of about 7,870 (219)

Astragalus Salvia Granules to Benefit the Qi (Qishen Yiqi Keli) protects H9C2 cardiomyocytes by suppressing oxidative stress

Journal of Traditional Chinese Medical Sciences, 2016
Objective: To investigate the effects of Qishen Yiqi Keli (QSYQ; Astragalus Salvia Granules to Benefit the Qi) on ROS scavenging and inhibition of NADPH oxidase in an effort to identify new natural antioxidants.
Bangze Fu, Shuzhen Guo, Xue Yu, Hong Chang, Wei Wang   +4 more
doaj   +1 more source

Mass Spectrometry Imaging‐Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa

Advanced Science, EarlyView.
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu, Wenna Duan, Weiwei Tang, Yucheng Zhao, Bin Li   +4 more
wiley   +1 more source

Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α

Drug Design, Development and Therapy, 2022
Jiali Zhao,1 En Lin,1 Chaonong Cai,1 Manyao Zhang,2 Decheng Li,1 Shanglin Cai,1 Guifang Zeng,1 Zeren Yin,1 Bo Wang,1 Peiping Li,1 Xiaopeng Hong,1 Jiafan Chen,1 Baojia Zou,1 Jian Li1 1Department of Hepatobiliary Surgery, Fifth Affiliated Hospital of Sun ...
Zhao J, Lin E, Cai C, Zhang M, Li D, Cai S, Zeng G, Yin Z, Wang B, Li P, Hong X, Chen J, Zou B, Li J   +13 more
doaj  

An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)

Exploration of Targeted Anti-tumor Therapy, 2020
Tanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of Salvia miltiorrhiza (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone I, have shown remarkable potential as anti-cancer ...
Irum Naz, Myriam Merarchi, Shanaya Ramchandani, Muhammad Rashid Khan, Muhammad Nouman Malik, Sumaira Sarwar, Acharan S Narula, Kwang Seok Ahn   +7 more
doaj   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]

, 2019
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y., Kankia, Ibrahim H., Langdon, Simon P., Paramasivan, Poornima   +3 more
core   +3 more sources

Anticancer effects of tanshinone I in human non-small cell lung cancer [PDF]

Molecular Cancer Therapeutics, 2008
Abstract Tanshinones are the major bioactive compounds of Salvia miltiorrhiza Bunge (Danshen) roots, which are used in many therapeutic remedies in Chinese traditional medicine. We investigated the anticancer effects of tanshinones on the highly invasive human lung adenocarcinoma cell line, CL1-5.
Chen-Yu, Lee, Hui-Fang, Sher, Huei-Wen, Chen, Chun-Chi, Liu, Ching-Hsien, Chen, Choun-Sea, Lin, Pan-Chyr, Yang, Hsin-Sheng, Tsay, Jeremy J W, Chen   +8 more
openaire   +2 more sources

SmMYB4 Is a R2R3-MYB Transcriptional Repressor Regulating the Biosynthesis of Phenolic Acids and Tanshinones in Salvia miltiorrhiza

Metabolites, 2022
Salvia miltiorrhiza Bunge is one of the most famous traditional Chinese medicinal plants. The two most important classes of pharmaceutically relevant compounds in S. miltiorrhiza are phenolic acids and tanshinones. The MYB family of transcription factors
Qian Tian, Limin Han, Xiaoya Zhu, Caijuan Zhang, Yunyun Li, Xiaoshan Xue, Yueyue Wang, Donghao Wang, Junfeng Niu, Wenping Hua, Bin Li, Zhezhi Wang   +11 more
doaj   +1 more source

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

Managing The Combination Of Nonalcoholic Fatty Liver Disease And Metabolic Syndrome With Chinese Herbal Extracts In High-fat-diet Fed Rats [PDF]

, 2013
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MetS). The aim of the study was to evaluate the effects of Chinese herbal extracts from Salvia miltiorrhiza and Gardenia jasminoides (SGE) on the combination of ...
Kamal, M, Lao, W, Qu, X, Seale, JP, Tan, Y, Wang, Z, Wei, X, Xiao, LH   +7 more
core   +4 more sources