Results 51 to 60 of about 21,115,427 (202)

Astragalus Salvia Granules to Benefit the Qi (Qishen Yiqi Keli) protects H9C2 cardiomyocytes by suppressing oxidative stress

open access: yesJournal of Traditional Chinese Medical Sciences, 2016
Objective: To investigate the effects of Qishen Yiqi Keli (QSYQ; Astragalus Salvia Granules to Benefit the Qi) on ROS scavenging and inhibition of NADPH oxidase in an effort to identify new natural antioxidants.
Bangze Fu   +4 more
doaj   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

open access: yesBiological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)

open access: yesExploration of Targeted Anti-tumor Therapy, 2020
Tanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of Salvia miltiorrhiza (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone I, have shown remarkable potential as anti-cancer ...
Irum Naz   +7 more
doaj   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

open access: yesiNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α

open access: yesDrug Design, Development and Therapy, 2022
Jiali Zhao,1 En Lin,1 Chaonong Cai,1 Manyao Zhang,2 Decheng Li,1 Shanglin Cai,1 Guifang Zeng,1 Zeren Yin,1 Bo Wang,1 Peiping Li,1 Xiaopeng Hong,1 Jiafan Chen,1 Baojia Zou,1 Jian Li1 1Department of Hepatobiliary Surgery, Fifth Affiliated Hospital of Sun ...
Zhao J   +13 more
doaj  

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

open access: yesPhytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia   +1 more
wiley   +1 more source

Tanshinone IIA: A new activator of human cardiac KCNQ1/KCNE1 (I Ks) potassium channels

open access: yes, 2008
Tanshinone IIA, one of the main active components from Chinese herb Danshen, is widely used to treat cardiovascular diseases including arrhythmia in Asian countries especially in China.
Li, GR   +7 more
core   +1 more source

Simultaneous Determination of Four Tanshinones by UPLC-TQ/MS and Their Pharmacokinetic Application after Administration of Single Ethanol Extract of Danshen Combined with Water Extract in Normal and Adenine-Induced Chronic Renal Failure Rats

open access: yesMolecules, 2016
Salvia miltiorrhiza, one of the major traditional Chinese medicines, is commonly used and the main active ingredients—tanshinones—possess the ability to improve renal function.
Hong-Die Cai   +8 more
doaj   +1 more source

SmMYB4 Is a R2R3-MYB Transcriptional Repressor Regulating the Biosynthesis of Phenolic Acids and Tanshinones in Salvia miltiorrhiza

open access: yesMetabolites, 2022
Salvia miltiorrhiza Bunge is one of the most famous traditional Chinese medicinal plants. The two most important classes of pharmaceutically relevant compounds in S. miltiorrhiza are phenolic acids and tanshinones. The MYB family of transcription factors
Qian Tian   +11 more
doaj   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

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