Results 61 to 70 of about 21,115,427 (202)

Content Determination and Chemical Clustering Analysis of Tanshinone and Salvianolic Acid in Salvia spp.

Metabolites
Salvia miltiorrhiza is one of the famous traditional Chinese medicines for treating cardiovascular and cerebrovascular diseases. Tanshinone and phenolic acids are the main active compounds of Salvia miltiorrhiza, whereas the distribution patterns of the ...
Feiyan Wang, Yufeng Bao, Furui Yang, Lu Yuan, Xinchun Han, Yanbo Huang, Yukun Wei, Lei Zhang, Zongqi Yang, Dongfeng Yang   +9 more
doaj   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, Volume 13, Issue 51, 14 September 2026.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Discovery of a Natural Syk Inhibitor from Chinese Medicine through a Docking-Based Virtual Screening and Biological Assay Study

Molecules, 2018
Spleen tyrosine kinase (Syk) is a critical target protein for treating immunoreceptor signalling-mediated allergies. In this study, a virtual screening of an in-house Chinese medicine database followed by biological assays was carried out to identify ...
Xing Wang, Junfang Guo, Zhongqi Ning, Xia Wu   +3 more
doaj   +1 more source

Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4/NF-κB p65 pathway after acute myocardial infarction

Frontiers in Cell and Developmental Biology, 2023
Background: Tanshinone IIA, derived from Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bunge), constitutes a significant component of this traditional Chinese medicine.
Ruoning Chai, Zelin Ye, Wenjing Xue, Shuqing Shi, Yi Wei, Yuanhui Hu, Huaqin Wu   +6 more
doaj   +1 more source

Novel Diterpenoids From Salvia rosmarinus Reveal a Compound With Antiproliferative and Antioxidant Activities

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Four novel diterpenoids were isolated from Salvia rosmarinus (rosemary), together with nine known compounds. ECD calculations were employed to establish the absolute configuration of diterpenoids 1 and 2. The 18‐hydroxycarnosol (1) was evaluated as antiproliferative (SRB assay) and antioxidant (DPPH and TBARS), showing promising results.
Diana Pérez‐Juanchi, Celia Bustos‐Brito, Ma. Teresa Ramírez‐Apan, Antonio Nieto‐Camacho, Leovigildo Quijano, Baldomero Esquivel   +5 more
wiley   +1 more source

Tanshinone production in roots of micropropagated Salvia przewalskii

, 2020
Production of tanshinones (tanshinone I and IIA) was determined in roots of Salvia przewalskii micropropagated plants. It was found that the total tanshinone content (tashinone I and tashinone IIA) was dependent on the age of the analyzed plants.
Halina Wysokiń, Ewa Skała
core  

Response of Endophytic Microbial Communities and Quality of Salvia miltiorrhiza to Fertilization Treatments

Microorganisms
Salvia miltiorrhiza is a traditional herbal remedy for cardiovascular diseases and is in high demand in the market. Excessive chemical fertilizer application, resulting from unscientific fertilization practices, reduced the tanshinone content in S ...
Wenjing Chen, Wanyun Li, Yangyang Pan, Xin Zheng, Xinxin Fu, Menghui Wang, Wenyi Shi, Zhenzhou Wang, Xueli He, Chao He, Xianen Li   +10 more
doaj   +1 more source

Bushen Huatan Formula Ameliorates Early Chronic Low‐Grade Inflammation in Obese PCOS Via the TLR4/NF‐κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This study used an integrated network pharmacology and experimental strategy to investigate how Bushen Huatan Formula (BHF) mitigates early‐stage chronic low‐grade inflammation in obese polycystic ovary syndrome (PCOS). Methods Candidate components and targets of BHF were retrieved from the TCMSP database, and protein–protein ...
Jianing Zhang, Fangyun Gu, Yunyun Li, Xiaoling Feng, Hongying Kuang, Fang Xu, Miao Sun   +6 more
wiley   +1 more source

Supplemental Material - Tanshinone I induces ferroptosis in gastric cancer cells via the KDM4D/p53 pathway

, 2023
Supplemental Material for Tanshinone I induces ferroptosis in gastric cancer cells via the KDM4D/p53 pathway by Minming Xia, Yifeng Wu, Hui Zhu and Wenbiao Duan in Human & Experimental ...
Wenbiao Duan (17439917), Hui Zhu (87035), Minming Xia (17439914), Yifeng Wu (2308579)   +3 more
core   +1 more source

The Expression Profiles of the Salvia miltiorrhiza 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase 4 Gene and Its Influence on the Biosynthesis of Tanshinones

Molecules, 2022
Salvia miltiorrhiza is a medicinal plant that synthesises biologically-active tanshinones with numerous therapeutic properties. An important rate-limiting enzyme in the biosynthesis of their precursors is 3-hydroxy-3-methylglutaryl-coenzyme A reductase ...
Małgorzata Majewska, Piotr Szymczyk, Jan Gomulski, Agnieszka Jeleń, Renata Grąbkowska, Ewa Balcerczak, Łukasz Kuźma   +6 more
doaj   +1 more source