Results 71 to 80 of about 7,870 (219)

Response of Endophytic Microbial Communities and Quality of Salvia miltiorrhiza to Fertilization Treatments

Microorganisms
Salvia miltiorrhiza is a traditional herbal remedy for cardiovascular diseases and is in high demand in the market. Excessive chemical fertilizer application, resulting from unscientific fertilization practices, reduced the tanshinone content in S ...
Wenjing Chen, Wanyun Li, Yangyang Pan, Xin Zheng, Xinxin Fu, Menghui Wang, Wenyi Shi, Zhenzhou Wang, Xueli He, Chao He, Xianen Li   +10 more
doaj   +1 more source

The Expression Profiles of the Salvia miltiorrhiza 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase 4 Gene and Its Influence on the Biosynthesis of Tanshinones

Molecules, 2022
Salvia miltiorrhiza is a medicinal plant that synthesises biologically-active tanshinones with numerous therapeutic properties. An important rate-limiting enzyme in the biosynthesis of their precursors is 3-hydroxy-3-methylglutaryl-coenzyme A reductase ...
Małgorzata Majewska, Piotr Szymczyk, Jan Gomulski, Agnieszka Jeleń, Renata Grąbkowska, Ewa Balcerczak, Łukasz Kuźma   +6 more
doaj   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Tanshinone Content Prediction and Geographical Origin Classification of Salvia miltiorrhiza by Combining Hyperspectral Imaging with Chemometrics

Foods
Hyperspectral imaging (HSI) technology was combined with chemometrics to achieve rapid determination of tanshinone contents in Salvia miltiorrhiza, as well as the rapid identification of its origins.
Yaoyao Dai, Binbin Yan, Feng Xiong, Ruibin Bai, Siman Wang, Lanping Guo, Jian Yang   +6 more
doaj   +1 more source

Enhanced production of tanshinone IIA in endophytic fungi Emericella foeniculicola by genome shuffling

Pharmaceutical Biology, 2018
Context: Tanshinone IIA, commercially produced from Salvia miltiorrhiza Bunge (C.Y.Wu) (Labiatae), has various biological benefits. Currently, this compound is mainly extracted from plants.
Pengyu Zhang, Yiting Lee, Xiying Wei, Jinlan Wu, Qingmei Liu, Shanning Wan   +5 more
doaj   +1 more source

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

Redox Biology, 2013
Exposure to solar ultraviolet (UV) radiation is a causative factor in skin photocarcinogenesis and photoaging, and an urgent need exists for improved strategies for skin photoprotection.
Shasha Tao, Rebecca Justiniano, Donna D. Zhang, Georg T. Wondrak   +3 more
doaj   +1 more source

Cardiovascular Benefits of Salvia miltiorrhiza (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Akash Vikal, Rashmi Maurya, Preeti Patel, Balak Das Kurmi, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Aldose Reductase Inhibitory Activity of Chinese Crude Drug "Danshen" [PDF]

, 2000
漢薬“丹参”の基源植物である丹参（Salvia miltiorhiza）及び中国新彊において丹参（S.miltiorhiza）の代用品として用いられている新彊丹参（S.deserta）のアルドース還元酵素阻害活性成分を調べたところ，両者の活性成分は全く異なっていた。さらに，丹参（S.miltiorhiza）の代用品として用いられている10種を含む17種類のSalvia属植物について，水およびメタノールエキスのアルドース還元酵素阻害活性およびLC-MS分析を比較した結果も ...
手塚 康弘, 門田 重利
core   +1 more source

Plant Growth and the Contents of Major Bioactive Compounds of Salvia miltiorrhiza Bunge Grown in Mississippi, United States

Horticulturae, 2023
Salvia miltiorrhiza Bunge (danshen) is a traditional herbal medicine and has been widely used to prevent and treat cardiovascular and other diseases. Currently, the majority of medicinal plants, including danshen, used in the United States are imported ...
Zhiheng Xing, Guihong Bi, Tongyin Li, Qianwen Zhang, Patricia R. Knight   +4 more
doaj   +1 more source

Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis

Drug Design, Development and Therapy, 2019
Xipeng Wang,1 Jianbo Fan,2 Xiaomin Ding,2 Yuyu Sun,2 Zhiming Cui,2 Wei Liu2 1Department of Orthopaedic Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430010, People’s Republic of
Wang X, Fan J, Ding X, Sun Y, Cui Z, Liu W   +5 more
doaj