Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish [PDF]
Molecules, 2012 The study aimed to investigate the potential of zebrafish in imitating mammal phase I metabolism of natural compounds. Three diterpenoid quinones from Radix Salvia miltiorrhiza, namely tanshinone IIA (TIIA), cryptotanshinone (Cry) and tanshinone I (TI ...
Luan Shu, Ping Li
exaly +6 more sources
Simultaneous purification of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA from Salvia miltiorrhiza and their anti-inflammatory activities investigation [PDF]
Scientific Reports, 2018 Dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA are major lipid-soluble constituents isolated from Salvia miltiorrhiza Bunge (Danshen).
Hongwei Gao +8 more
core +3 more sources
Anticancer effects of tanshinone I in human non-small cell lung cancer [PDF]
Molecular Cancer Therapeutics, 2014 Tanshinones are the major bioactive compounds of Salvia miltiorrhiza Bunge (Danshen) roots, which are used in many therapeutic remedies in Chinese traditional medicine.
Tsay, H.S. +10 more
core +4 more sources
In vitro anti-tumor activity of the tanshinone IIA against SKOV3 cells [PDF]
Natural Product Research, 2015 The aim of this study was to determine the anti-tumour activity of tanshinone IIA in SKOV3 cells. Results suggested that tanshinone IIA could significantly inhibit (IC50 value = 19.6 μM) the proliferation and induce apoptosis of SKOV3 cells as ...
YingKai Hong (806292) +2 more
core +3 more sources
Smi-miR164a positively regulates phenolic acid biosynthesis while negatively regulates tanshinone production in Salvia miltiorrhiza [PDF]
Frontiers in Plant ScienceIntroductionMicroRNAs (miRNAs) are key post-transcriptional regulators of plant secondary metabolism. Their primary mechanism involves silencing target genes through mRNA cleavage or translational inhibition, which is a major focus of current research in
Huaqian You +4 more
doaj +2 more sources
The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV [PDF]
Redox Biology, 2013 Exposure to solar ultraviolet (UV) radiation is a causative factor in skin photocarcinogenesis and photoaging, and an urgent need exists for improved strategies for skin photoprotection.
Shasha Tao +3 more
doaj +2 more sources
Pharmaceutical Biology, 2018 Context: Tanshinone IIA, commercially produced from Salvia miltiorrhiza Bunge (C.Y.Wu) (Labiatae), has various biological benefits. Currently, this compound is mainly extracted from plants.
Pengyu Zhang +5 more
doaj +2 more sources
Total synthesis of (±)-tanshinol B, tanshinone I, and (±)-tanshindiol B and C
Organic & Biomolecular Chemistry, 2018 A concise and efficient approach was established for the divergent total synthesis of (±)-tanshinol B, (±)-tanshindiol B, (±)-tanshindiol C, and tanshinone I in 17–50% overall yield over 3–6 steps.
Meiyu Geng +8 more
core +3 more sources
Simultaneous quantitative analyses of Tanshinone I, Cryptotanshinone, and Tanshinone IIA in Danshen (Salvia miltiorrhiza Bunge) cultivated in Vietnam using LC-MS/MS [PDF]
, 2021 By using chromatography methods, the principal compounds tanshinon I, cryptotanshinone, tanshinone IIA were isolated from danshen (Salvia miltiorrhiza Bunge).
Trung, Van-Hoang ; Institute of Chemistry, Biology and Environment, Vinh University 460000, Vietnam +6 more
core +5 more sources
Analysis of the HD-Zip I transcription factor family in Salvia miltiorrhiza and functional research of SmHD-Zip12 in tanshinone synthesis [PDF]
PeerJ, 2023 Background The homeodomain-leucine zipper I (HD-Zip I) transcription factor is a plant-specific protein that plays an essential role in the abiotic stress response of plants.
Yanhong Bai +7 more
doaj +2 more sources