Results 181 to 190 of about 5,245 (194)

Mechanisms of the dilator action of cryptotanshinone on rat coronary artery

European Journal of Pharmacology, 2008
In this study, we have investigated the actions of cryptotanshinone, an active, lipophilic component of the medicinal herb danshen (Salvia miltiorrhiza), on rat isolated coronary artery rings precontracted with 1 microM 5-hydroxytryptamine (5-HT) and its action compared to the ethanol-extractable fraction of the herb.
Francis F Y, Lam, John H K, Yeung, Kam M, Chan, Penelope M Y, Or   +3 more
openaire   +2 more sources

Cryptotanshinone inhibits VEGF-induced angiogenesis by targeting the VEGFR2 signaling pathway

Microvascular Research, 2017
Anti-angiogenesis has been proposed as an important strategy for angiogenesis-related diseases. Cryptotanshinone (CPT), an active component of Salvia miltiorrhiza, may be a potential inhibitor of angiogenesis. However, the molecular mechanisms underlying its anti-angiogenic activities remain poorly understood.
Xiaoming Xu, Li Wu, Xinbin Zhou, Nanyang Zhou, Qin Zhuang, Jinxiu Yang, Jin Dai, Haibing Wang, Shenjie Chen, Wei Mao   +9 more
openaire   +2 more sources

Rotwurzelsalbei und Cryptotanshinon: spezifische Inhibitoren der Keratinisierung von Hautzellen

Zeitschrift für Phytotherapie, 2019
Die getrockneten Rhizome und Wurzeln von Salvia miltiorrhiza Bunge sind eine in der Traditionellen Chinesischen Medizin (TCM) – dort als Danshen oder Dan Shen bezeichnete – sehr häufig verwendete Droge. Die Droge ist mittlerweile auch im Europäischen Arzneibuch monografiert. S.
Andreas Hensel, Stefan Esch
openaire   +1 more source

PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA

Chemico-Biological Interactions, 2009
Danshen (Radix Salvia miltiorrhiza) is a famous Traditional Chinese Medicine used widely for the treatment of coronary heart disease and cerebrovascular disease. Diterpenoid tanshinones including tanshinone I, tanshinone IIA and cryptotanshinone are the major bioactive components from Danshen herb.
Chunna, Yu, Shanshan, Ye, Hongying, Sun, Yao, Liu, Lingbo, Gao, Chaofeng, Shen, Shuqing, Chen, Su, Zeng   +7 more
openaire   +2 more sources

A Review of Cryptotanshinone and its Nanoformulation in Cancer Therapy

Anti-Cancer Agents in Medicinal Chemistry
Cancer, with a high incidence and mortality rate, has emerged as a major public health problem worldwide. Currently, new approaches, such as targeted therapy and immunotherapy, are giving hope to patients. However, drug resistance and adverse side effects are major barriers to cancer treatment. As a result, there is a greater focus on the development
Xin, Liu, Yahan, Gao, Fan, Yang, Min, Qian, Shuhui, You, Xiaoxiao, Wang, Fenju, Qin, Min, Xiang, Weiqiang, Guo   +8 more
openaire   +2 more sources

Cryptotanshinone induces ROS-dependent autophagy in multidrug-resistant colon cancer cells

Chemico-Biological Interactions, 2017
The development of novel chemotherapeutic agents is highly desired for colon cancer treatment, in particular for the multidrug-resistant cancer types. Cryptotanshinone (CTS), an active quinoid diterpene isolated from Salvia miltiorrhiza Bunge, was previously reported to induce autophagy in various colon cancer cell lines.
Zhenyu, Xu, Hui, Jiang, Yanhong, Zhu, Huifang, Wang, Jia, Jiang, Lu, Chen, Wenke, Xu, Tao, Hu, Chi Hin, Cho   +8 more
openaire   +2 more sources

Salvia miltiorrhiza: In Vitro Production of Cryptotanshinone and Ferruginol

1989
Salvia miltiorrhiza Bunge (Labiatae), growing wild in China, is a perennial herb (Fig. 1), 30 to 80 cm high, and the root of this plant, called Tan-shen in Chinese and Tan-jin in Japanese, is an ancient Chinese drug, ranked as a super-grade medicine in “Shen-nung-pen-tsao-ching”, the oldest classical Chinese herbal. It has been widely used in China for
H. Miyasaka, M. Nasu, K. Yoneda
openaire   +1 more source

Design, Synthesis and Cardioprotection of Cryptotanshinone Derivatives

Chinese Journal of Organic Chemistry, 2022
Yuefeng Bi, Donghao Wang, Die Li, Lei Kang, Jiahui Xu, Xintao Cheng, Jiahui Zhou, Fangfeng Meng   +7 more
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[Formulation study on cryptotanshinone gel for topical administration].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011
To screen the formulations of cryptotanshinone gel for treatment of topical diseases such as acne.Different cryptotanshinone gels incorporating various penetration enhancers at different concentrations were prepared using carbopol 934L as matrix. The steady transdermal fluxes and drug retention amounts in skin of the gels were investigated on single ...
Zhenwei, Yu, Wenquan, Liang
openaire   +1 more source

Synthesis of tanshinone-II and cryptotanshinone

Tetrahedron Letters, 1968
H. Kakisawa, M. Tateishi, T. Kusumi
openaire   +1 more source