Results 91 to 100 of about 470,484 (314)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Coaxial Core Shell Overgrowth of Zeolite L − Dependence on Original Crystal Growth Mechanism [PDF]

, 2010
In this study, the first reported core-shell material combining zeolite L (LTL) and barium-exchanged zeolite L (Ba-LTL) is described The use of atomic force microscopy to probe the LTL surface growth mechanism was employed to understand the growth ...
Rhea Brent, Sam M. Stevens, Stevens, Sam M.,, Anderson, Michael W., Terasaki, Osamu,, Brent, Rhea, Michael W. Anderson, Osamu Terasaki   +7 more
core   +1 more source

Fabrication and Optical Properties of 2at.%Yb:LuYAG Mixed Crystal through Nanocrystalline Powders

Crystals, 2018
Ytterbium doped Lu1.5Y1.5Al5O12 (LuYAG) nanocrystalline powders were synthesized by a wet chemical mixed precipitant co-precipitation (MPP) method, and then the mixed crystal of Yb:LuYAG was grown in an optical floating zone (OFZ) furnace at the speed of
Ding Zhou, Meiqi Yang, Jiayue Xu, Yijian Jiang, Yunfeng Ma, Ying Shi   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Influence of In³⁺ on the Crystal Growth and Visible Band Photorefraction of Uranium-Doped Lithium Niobate Single Crystals

Crystals
A series of lithium niobate crystals co-doped with uranium and indium was successfully grown by the modified vertical Bridgman method for the first time.
Tian Tian, Wenjie Xu, Chenkai Fang, Yuheng Chen, Hongde Liu, Yaoqing Chu, Hui Shen, Jiayue Xu   +7 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Electrical and magnetic properties of NiTiO3 nanoparticles synthesized by the sol–gel synthesis method and microwave sintering

Journal of Materials Research and Technology, 2019
In this paper, we focused on microwave sintered NiTiO3 nanoparticles synthesized via sol–gel method. The crystal structure was determined by the X-ray diffraction.
Pavithra C., Madhuri W.
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The convection during NaClO3 crystal growth observed by the phase shift interferometer [PDF]

, 2001
An optical diagnostic system consisting of the Mach-Zehnder interferometer with the phase shift device and an image processor has been developed for the study of the kinetics of the crystal growing process.
段俐, Duan, L (reprint author), Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, 15 Zhong Guan Cun Rd, Beijing 100080, Peoples R China., 束继祖   +2 more
core   +1 more source