Results 91 to 100 of about 12,568,246 (360)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Crystal structure of catena-poly[[cadmium(II)-di-μ2-bromido-μ2-l-proline-κ2O:O′] monohydrate]

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title coordination polymer, {[CdBr2(C5H9NO2)]·H2O}n, the CdII ion is coordinated by four bromido ligands and two carboxylate oxygen atoms of two symmetry-related proline ligands, which exist in a zwitterionic form, in a distorted octahedral ...
S. Sathiskumar, T. Balakrishnan, K. Ramamurthi, S. Thamotharan   +3 more
doaj   +1 more source

Numerical modeling of SiC single crystal growth-sublimation and hot-wall epitaxy

, 2009
On the engineering point of view, it is important to develop a design technology of the furnace for SiC single crystal growth. In this point of view, the recent progress of modeling on both sublimation bulk growth and hot-wall epitaxy were presented. For
Nishizawa, Shin-ichi,
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Fabrication and Optical Properties of 2at.%Yb:LuYAG Mixed Crystal through Nanocrystalline Powders

Crystals, 2018
Ytterbium doped Lu1.5Y1.5Al5O12 (LuYAG) nanocrystalline powders were synthesized by a wet chemical mixed precipitant co-precipitation (MPP) method, and then the mixed crystal of Yb:LuYAG was grown in an optical floating zone (OFZ) furnace at the speed of
Ding Zhou, Meiqi Yang, Jiayue Xu, Yijian Jiang, Yunfeng Ma, Ying Shi   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Rapid prediction of interface morphology and oxygen transportation in crystal growth based on the response surface method

In this paper, a two-dimensional (2D) axisymmetric model subjected to the gas shear effect and thermal Marangoni effect is developed. It is highlighted that the growth conditions of pulling rate, gas flow rate, crucible, and crystal rotation rates play ...
Li, Kai, Hu, Wenrui, Yan, Dongxiu, Zhao, Jianfu, Guo, Ziyi, Chen, Xue   +5 more
core   +2 more sources

The Influence of In³⁺ on the Crystal Growth and Visible Band Photorefraction of Uranium-Doped Lithium Niobate Single Crystals

Crystals
A series of lithium niobate crystals co-doped with uranium and indium was successfully grown by the modified vertical Bridgman method for the first time.
Tian Tian, Wenjie Xu, Chenkai Fang, Yuheng Chen, Hongde Liu, Yaoqing Chu, Hui Shen, Jiayue Xu   +7 more
doaj   +1 more source

Bulk Crystal growth and Characterization of Organic Nonlinear Optical Crystal: 2-(2,4-dimethoxybenzylidene) malononitrile (DMM)

, 2017
International audienceBulk organic nonlinear optical single crystal of 2-(2,4-dimethoxybenzylidene) malononitrile (DMM) with size up to 24×18×13 mm 2 was successfully grown by slow evaporation solution growth technique.
Priyadharshini, A, Kalainathan, S
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source