Results 31 to 40 of about 35,870 (260)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Crystal Plasticity Modeling of Mechanical Anisotropy for TiAl Alloy Under Uniaxial and Biaxial Loading

Crystals
TiAl alloys are widely used in aerospace applications due to their low density and good mechanical properties. However, their pronounced mechanical anisotropy resulting from the preferred orientations of lamellar crystals remains an important issue. This
Wenya Peng, Chunling Zhao, Kun Leng, Kanghe Jiang, Weihua Meng, Bin Ding, Qinghu Meng, Wencheng Liu   +7 more
doaj   +1 more source

基于多尺度晶体塑性有限元的GCr15轴承钢拉-压不对称性研究

Jixie qiangdu, 2021
In this paper,stress triaxiality is added to the classical crystal plasticity constitutive model to investigate the experimental phenomenon of tension-compression asymmetry for the GCr15 bearing steel.Firstly, the crystal plasticity constitutive model is
樊冬, 余丰, 李淑欣
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Study on the irradiation effect of mechanical properties of RPV steels using crystal plasticity model

Nuclear Engineering and Technology, 2019
In this paper a body-centered cubic(BCC) crystal plasticity model based on microscopic dislocation mechanism is introduced and numerically implemented.
Junfeng Nie, Yunpeng Liu, Qihao Xie, Zhanli Liu   +3 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

High-resolution simulating of grain substructure in cold rolling and its effects on primary recrystallization in annealing of ferritic stainless steel

Journal of Materials Research and Technology
In this study, an integrated crystal plasticity and cellular automaton (CA) model has been developed and employed to investigate the processes of cold rolling and annealing in ferritic stainless steel.
Kangjie Song, Haochen Ding, Chi Zhang, Liwen Zhang, Guanyu Deng, Huaibei Zheng   +5 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source