Results 41 to 50 of about 127,612 (336)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Study on the irradiation effect of mechanical properties of RPV steels using crystal plasticity model

Nuclear Engineering and Technology, 2019
In this paper a body-centered cubic(BCC) crystal plasticity model based on microscopic dislocation mechanism is introduced and numerically implemented.
Junfeng Nie, Yunpeng Liu, Qihao Xie, Zhanli Liu   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A multiscale constitutive model for intergranular stress corrosion cracking in type 304 austenitic stainless steel [PDF]

, 2013
Intergranular stress corrosion cracking (IGSCC) is a fracture mechanism in sensitised austenitic stainless steels exposed to critical environments where the intergranular cracks extends along the network of connected susceptible grain boundaries.
Rahimi, S, Siddiq, A
core   +2 more sources

Crystal Plasticity Modeling of Mechanical Anisotropy for TiAl Alloy Under Uniaxial and Biaxial Loading

Crystals
TiAl alloys are widely used in aerospace applications due to their low density and good mechanical properties. However, their pronounced mechanical anisotropy resulting from the preferred orientations of lamellar crystals remains an important issue. This
Wenya Peng, Chunling Zhao, Kun Leng, Kanghe Jiang, Weihua Meng, Bin Ding, Qinghu Meng, Wencheng Liu   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Crystal plasticity model calibration for 316l stainless steel single crystals during deformation [PDF]

, 2013
Type 316L austenitic stainless steel is an important structural material used for the in-core components and pressure boundaries of light water reactors.
Bogataj, Matej, Cizelj, Leon, El Shawish, Samir   +2 more
core  

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

High-resolution simulating of grain substructure in cold rolling and its effects on primary recrystallization in annealing of ferritic stainless steel

Journal of Materials Research and Technology
In this study, an integrated crystal plasticity and cellular automaton (CA) model has been developed and employed to investigate the processes of cold rolling and annealing in ferritic stainless steel.
Kangjie Song, Haochen Ding, Chi Zhang, Liwen Zhang, Guanyu Deng, Huaibei Zheng   +5 more
doaj   +1 more source

A Combined Experimental-Numerical Approach for Investigating Texture Evolution of NiTi Shape Memory Alloy under Uniaxial Compression

Metals, 2017
Texture evolution of NiTi shape memory alloy was investigated during uniaxial compression deformation at 673 K (400 °C) by combining crystal plasticity finite element method with electron back-scattered diffraction experiment and transmission electron ...
Li Hu, Shuyong Jiang, Yanqiu Zhang
doaj   +1 more source