Results 81 to 90 of about 595,112 (241)

Role of Tunneling Nanotubes in Arachidonic Acid Transfer and Macrophage Function Reprogramming in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
Tunneling nanotubes facilitate the transfer of long‐chain fatty acids, primarily arachidonic acid, from tumor cells to macrophages, leading to lipid accumulation and activation of the PI3K‐Akt pathway. This drives a shift from the anti‐tumor CD5L⁺ phenotype to a pro‐tumor TREM2⁺ phenotype.
Meiru Chen, Shangyumeng Zhao, Xiaoli Xie, Jiaqi Wang, Miao Su, Lixian Zhang, Ruolin Cui, Dongqiang Zhao   +7 more
wiley   +1 more source

Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T‐Cell Function and Anti‐PD‐1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T‐Cell‐Incorporated Tumor Organoid Studies

Advanced Science, EarlyView.
Through metabolomic and transcriptomic analyses, a glutamine‐enriched, immunosuppressive microenvironment is identified in cervical squamous cell carcinoma (CSCC), highlighting the glutamine transporter SLC25A22 as a key regulator of glutamine metabolism, immune checkpoint activation, and CD8+ T‐cell cytotoxicity.
Tingting Ren, Junjun Qiu, Fanghua Chen, Qian Jiang, Qinqin Liu, Tong Wu, Hua Jiang, Keqin Hua   +7 more
wiley   +1 more source

Research reports: 1985 NASA/ASEE Summer Faculty Fellowship Program [PDF]

A compilation of 40 technical reports on research conducted by participants in the 1985 NASA/ASEE Summer Faculty Fellowship Program at Marshall Space Flight Center (MSFC) is given.
Dozier, J. B., Freeman, L. M., Karr, G. R., Osborn, T. L.   +3 more
core   +1 more source

Directional Ion Transport Through Nanoarchitected 1D Mesochannels: 2D Polymer Interfacial Engineering for High‐Efficiency Capacitive Deionization

Advanced Science, EarlyView.
The engineering 2D polymer/graphene heterostructures with aligned 1D mesochannels synergizes directional ion transport pathways, corrosion‐resistant interfaces, and rapid electron highways, overcoming traditional bottlenecks. The design scalability and tunability enable universal adaptation to diverse redox‐active polymers, while its mechanistic ...
Chen Tang, Hongli Chen, Qian Li, Changle Li, Ying Li, Azhar Alowasheeir, Zeinhom M El‐Bahy, Guoxiu Wang, Chongyin Zhang, Yusuke Yamauchi, Xingtao Xu   +10 more
wiley   +1 more source

Stiffness‐Tunable Neurotentacles for Minimally Invasive Implantation and Long‐Term Neural Activity Recordings

Advanced Science, EarlyView.
A hydraulically actuated “Neurotentacle” probe offers tunable stiffness for precise implantation into the deep brain without rigid shuttles or dissolvable coatings. It stiffens during insertion to penetrate tissue and softens afterward to minimize damage and enable stable long‐term recordings.
Yang Wang, Xing Xu, Xiaowei Yang, Rongyu Tang, Ying Chen, Shan Zang, Yijun Wang, Jing Liang, Weihua Pei   +8 more
wiley   +1 more source

Low‐Temperature Annealing Triggered Abnormal Strengthening in a Complex Concentration Alloy via Evolutive Short‐Range Ordering

Advanced Science, EarlyView.
Low‐temperature annealing enhances strength, ductility, and work hardening in CoNiV MEA. This originates from multi‐scale chemical short‐range orderings (SROs) formed during annealing, which promote dislocation slip planarity and reduce entanglement, enabling balanced mechanical properties through ordering strengthening.
Yihan Wang, Yuan Wu, Yong Yu, Yang He, Xinyang Yu, Xiongjun Liu, Hui Wang, Suihe Jiang, Xiaobin Zhang, Zhaoping Lu   +9 more
wiley   +1 more source

From Design to Production Control Through the Integration of Engineering Data Management and Workflow Management Systems

, 1997
At a time when many companies are under pressure to reduce "times-to-market" the management of product information from the early stages of design through assembly to manufacture and production has become increasingly important.
Baker, N., Bazan, A., Bityukov, S., Chevenier, G., Estrella, F., Flour, T. Le, Goff, J-M. Le, Kovacs, Z., Lieunard, S., McClatchey, R., Murray, S., Organtini, G., Vialle, J-P.   +12 more
core   +1 more source

Establishment of “Structure‐Efficiency” Relationship in Ultra‐High Purity Metal Systems: Multi‐Scale Analysis of Tellurium as a Prototype

Advanced Science, EarlyView.
By combining theoretical calculations with zone refining experiments, the quantitative relationship between purification efficiency and microstructure can be established. This multi‐scale investigation establishes a comprehensive framework for understanding the “structure‐efficiency” relationship in ultra‐high‐purity metals, providing theoretical ...
Shuai Guo, Xianglei Dong, Lin Zheng, Ming Gao, Guoqin Cao, Ping Peng, Jilin He, Junhua Hu   +7 more
wiley   +1 more source

Cross-language compiler benchmarking: are we fast yet?

Dynamic Languages Symposium, 2016
Stefan Marr, Benoit Daloze, H. Mössenböck   +2 more
semanticscholar   +1 more source

Biomolecular Interaction Prediction: The Era of AI

Advanced Science, EarlyView.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source