Results 61 to 70 of about 622,957 (315)
Acta Crystallographica Section E: Crystallographic Communications, 2017 The complete molecules of the title compounds, N2,N5-bis(pyridin-2-ylmethyl)pyrazine-2,5-dicarboxamide, C18H16N6O2 (I), 3,6-dimethyl-N2,N5-bis(pyridin-2-ylmethyl)pyrazine-2,5-dicarboxamide, C20H20N6O2 (II), and N2,N5-bis(pyridin-4-ylmethyl)pyrazine-2,5 ...
Dilovan S. Cati, Helen Stoeckli-Evans
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Crystal structure of pseudoguainolide [PDF]
Acta Crystallographica Section E Crystallographic Communications, 2015 The lactone ring in the title molecule, C15H22O3(systematic name: 3,4a,8-trimethyldodecahydroazuleno[6,5-b]furan-2,5-dione), assumes an envelope conformation with the methine C atom adjacent to the the methine C atom carrying the methyl substituent being the flap atom.
Noureddine Beghidja +4 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Crystal Structure Of 2-chloro-2-(chloromethyl)-5-(1-hydroxy-isopropyl) Cyclohexane-1-ol, C10h18cl2o2
, 2015 C10H18Cl2O2, monoclinic, P1211 (no. 4), a = 7.9492(9) Å, b = 7.8317(9) Å, c = 9.632(1) Å, β= 98.275(8)°, V = 593.4 Å3, Z = 2, Rgt(F) = 0.041, wRref(F2) = 0.127, T= 293 K.
Coelho D.C.S. +3 more
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Deep Learning Classification of Crystal Structures Utilizing Wyckoff Positions
, 2022 In materials science, crystal lattice structures are the primary metrics used to measure the structure–property paradigm of a crystal structure.
Hanan Ahmed Hosni Mahmoud +1 more
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Crystal structure of fenclorim
Acta Crystallographica Section E Crystallographic Communications, 2015 In the title compound, C10H6Cl2N2(systematic name: 4,6-dichloro-2-phenylpyrimidine), which is used commercially as the herbicide safener, fenclorim, the dihedral angle between the dichloropyrimidyl and phenyl rings is 9.45 (10)°. In the crystal, C—H...N hydrogen bonds link adjacent molecules, forming chains along thec-axis direction.
Eunjin Kwon +3 more
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Crystal structure of fluroxypyr [PDF]
Acta Crystallographica Section E Crystallographic Communications, 2016 In the title pyridine herbicide {systematic name: 2-[(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy]acetic acid}, C7H5Cl2FN2O3, the mean plane of the carboxylic acid substituent and the pyridyl ring plane subtend a dihedral angle of 77.5 (1)°. In the crystal, pairs of O—H...O hydrogen bonds form inversion dimers withR22(8) ring motifs.
Hyunjin Park +3 more
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
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Crystal structures of two alanylpiperidine analogues
Acta Crystallographica Section E: Crystallographic Communications, 2021 The structure of ethyl 1-[N-(4-methylphenyl)-N-(methylsulfonyl)alanyl]piperidine-4-carboxylate, C19H28N2O5S, I, a compound of interest as activator of Ubiquitin C-terminal Hydrolase-L1 (UCH-L1), was determined by single-crystal X-ray diffraction (SCXRD ...
Kalina Mambourg +5 more
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