Results 21 to 30 of about 43,221 (257)

Creatine kinase/α-crystallin interaction functions in cataract development

Biochemistry and Biophysics Reports, 2020
Creatine kinase (CK) is an energy storage enzyme that plays an important role in energy metabolism. CK/phosphocreatine functions as an energy buffer and links ATP production sites with ATP utilization sites.
Paul D. Hamilton, Stephanie L. Bozeman, Usha P. Andley   +2 more
doaj   +1 more source

αB-Crystallin Alleviates Endotoxin-Induced Retinal Inflammation and Inhibits Microglial Activation and Autophagy

Frontiers in Immunology, 2021
αB-Crystallin, a member of the small heat shock protein (sHSP) family, plays an immunomodulatory and neuroprotective role by inhibiting microglial activation in several diseases.
Fangyu Wang, Zhaoxin Jiang, Bingsheng Lou, Fang Duan, Suo Qiu, Zhixing Cheng, Xinqi Ma, Yao Yang, Xiaofeng Lin   +8 more
doaj   +1 more source

Rescue of Retinal Degeneration in rd1 Mice by Intravitreally Injected Metformin

Frontiers in Molecular Neuroscience, 2019
Retinitis pigmentosa (RP) is a progressive hereditary retinal degenerative disease in which photoreceptor cells undergo degeneration and apoptosis, eventually resulting in irreversible loss of visual function. Currently, no effective treatment exists for
Luodan A, Luodan A, Luodan A, Ting Zou, Ting Zou, Juncai He, Juncai He, Xia Chen, Xia Chen, Dayu Sun, Dayu Sun, Xiaotang Fan, Haiwei Xu, Haiwei Xu   +13 more
doaj   +1 more source

Impacts of the combined exposure to seawater acidification and arsenic on the proteome of Crassostrea angulata and Crassostrea gigas [PDF]

, 2018
Proteomic analysis was performed to compare the effects of Arsenic (As), seawater acidification (Low pH) and the combination of both stressors (Low pH + As) on Crassostrea angulata and Crassostrea gigas juveniles in the context of global environmental ...
Bebianno, Maria, Figueira, Etelvina, Freitas, Rosa, Mestre, Nélia, Moreira, Anthony, Schrama, Denise, Soares, Amadeu M.V.M.   +6 more
core   +1 more source

Protective Effects of Lanosterol Synthase Up-Regulation in UV-B-Induced Oxidative Stress

Frontiers in Pharmacology, 2019
UV-B radiation may be an important risk factor in cataract etiology. After exposure to UV-B radiation, cells show imbalances in the repair of DNA damage, which induce changes in the levels of certain proteins, including alpha-crystallin, which is the ...
Hui Hua, Tianyao Yang, Liting Huang, Rentong Chen, Menglin Li, Zhenzhen Zou, Nan Wang, Dan Yang, Yang Liu   +8 more
doaj   +1 more source

Association of Alpha-Crystallin with Fiber Cell Plasma Membrane of the Eye Lens Accompanied by Light Scattering and Cataract Formation

Membranes, 2021
α-crystallin is a major protein found in the mammalian eye lens that works as a molecular chaperone by preventing the aggregation of proteins and providing tolerance to stress in the eye lens.
Raju Timsina, Laxman Mainali
doaj   +1 more source

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]

, 2012
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Abdul HM, Alice L. Yu, Aslan M, Bilska A, Buniatian GH, Cabell L, Carini M, Chong MS, Esposito G, Fuchshofer R, Fuchshofer R, Fukuchi T, Furuyoshi N, Gaitanaki C, Hatten ME, He S, Hernandez MR, Hernandez MR, Hernandez MR, Hernandez MR, Hodges NJ, Ihnat MA, Izzotti A, Jerome Moriniere, Kobayashi S, Kumar DM, Lambert W, Louhelainen M, Lutjen-Drecoll E, Malone PE, Markesbery WR, Meldrum B, Mozaffarieh M, Neufeld AH, Neumann C, Ohia SE, Oksala NK, Oksala NK, Pena JD, Picht G, Proell V, Ridet JL, Sacca SC, Salinthone S, Samali A, Sharp FR, Shin JH, Smith AR, Sturrock A, Tezel G, Tezel G, Tripathi RC, Ulrich Welge-Lussen, Valencia A, Veach J, Várkonyi T, Yang KL, Yang P, Yu AL, Yu AL, Zimmer DB   +60 more
core   +1 more source

Crystalline Catalase

Science, 1937
Sumner, James B. and Dounce, Alexander L. Crystalline Catalase, 1937 ; https://digitalcommons.rockefeller.edu/pamphlets-offprints-and-reprints/1045/thumbnail ...
Sumner, James B., Dounce, Alexander L.
openaire   +2 more sources

BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity. [PDF]

PLoS ONE, 2011
A homozygous disruption or genetic mutation of the bag3 gene causes progressive myofibrillar myopathy in mouse and human skeletal and cardiac muscle disorder while mutations in the small heat shock protein αB-crystallin gene (CRYAB) are reported to be ...
Akinori Hishiya, Mortada Najem Salman, Serena Carra, Harm H Kampinga, Shinichi Takayama   +4 more
doaj   +1 more source

Cytoplasmic and nuclear anti-apoptotic roles of αB-crystallin in retinal pigment epithelial cells. [PDF]

PLoS ONE, 2012
In addition to its well-characterized role in the lens, αB-crystallin performs other functions. Methylglyoxal (MGO) can alter the function of the basement membrane of retinal pigment epithelial (RPE) cells.
Woo Jin Jeong, Jee Hyun Rho, Young Geol Yoon, Seung Hee Yoo, Na Young Jeong, Won Yeol Ryu, Hee Bae Ahn, Woo Chan Park, Sae Heun Rho, Hee Seong Yoon, Yung Hyun Choi, Young Hyun Yoo   +11 more
doaj   +1 more source