Results 41 to 50 of about 43,221 (257)

αB-Crystallin Peptide Fused with Elastin-like Polypeptide: Intracellular Activity in Retinal Pigment Epithelial Cells Challenged with Oxidative Stress

Antioxidants, 2023
Background: Oxidative stress-induced retinal degeneration is among the main contributing factors of serious ocular pathologies that can lead to irreversible blindness.
Sara Aly Attia, Anh Tan Truong, Alvin Phan, Shin-Jae Lee, Manal Abanmai, Marinella Markanovic, Hugo Avila, Haozhong Luo, Atham Ali, Parameswaran G. Sreekumar, Ram Kannan, J. Andrew MacKay   +11 more
doaj   +1 more source

In vitro interactions of histones and α-crystallin

Biochemistry and Biophysics Reports, 2018
The aggregation of crystallins in lenses is associated with cataract formation. We previously reported that mutant crystallins are associated with an increased abundance of histones in knock-in and knockout mouse models.
Paul D. Hamilton, Usha P. Andley
doaj   +1 more source

A native chemical chaperone in the human eye lens

eLife, 2022
Cataract is one of the most prevalent protein aggregation disorders and still the most common cause of vision loss worldwide. The metabolically quiescent core region of the human lens lacks cellular or protein turnover; it has therefore evolved ...
Eugene Serebryany, Sourav Chowdhury, Christopher N Woods, David C Thorn, Nicki E Watson, Arthur A McClelland, Rachel E Klevit, Eugene I Shakhnovich   +7 more
doaj   +1 more source

Crystalline Nephropathies [PDF]

Archives of Pathology & Laboratory Medicine, 2012
Context.—The kidney is a favored site for crystal deposition because of the high concentration of ions and molecules reached at the level of the renal tubules in the course of filtration. This review focuses on crystalline nephropathies in 4 broad categories: (1) dysproteinemia- associated, (2) drug-induced, (3) calcium-containing, and (4) metabolic or
Leal C, Herlitz, Vivette D, D'Agati, Glen S, Markowitz   +2 more
openaire   +2 more sources

Deciphering the association of intronic single nucleotide polymorphisms of crystallin gene family with congenital cataract

Indian Journal of Ophthalmology, 2021
Purpose: Introns play an important role in gene regulation and expression. Single nucleotide polymorphisms (SNPs) in introns have the potential to cause disease and alter the genotype–phenotype association.
Vidya Nair, Rajkumar Sankaranarayanan, Abhay Raghukant Vasavada   +2 more
doaj   +1 more source

Small but crucial : the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans [PDF]

, 2012
Peer reviewedPublisher ...
A Dereeper, A Hartl, A Hubel, A Shonhai, A Walther, A Yamamoto, AA Sanchez, AF Ram, AJ Brown, AJP Brown, Alistair J. P. Brown, AM Gillum, AM Murad, B Eisman, B Enjalbert, B Enjalbert, B Enjalbert, B Hube, B Wachtler, Bernhard Hube, C Askew, C Csank, C Fradin, C Gancedo, C Schuller, CA Kumamoto, CC Sheth, CF Urban, CJ Nobile, D Harcus, D Ribatti, DA Smith, DL Richie, DM Arana, Duncan Wilson, E Roman, EA Craig, F Estruch, F Moller, F Narberhaus, FA Castro, FC Odds, FJ Alvarez-Peral, François L. Mayer, G Butler, GJ Caspers, GR Stewart, H Liu, H Park, H Ruis, H Wisplinghoff, H Yamaguchi, HJ Lo, HT Rupniak, ID Jacobsen, ID Jacobsen, Ilse D. Jacobsen, Iryna M. Bohovych, J Buchner, J Fan, J Ferrer, J Horwitz, JC Arguelles, JD Malhotra, JN Sun, JP Burnie, JR Glover, K Richter, K Sales, K Zakikhany, KD Metzler, KL Meibom, L Petko, LE Cowen, LL Hoyer, LY Chiang, M Chaput, M Haslbeck, M Haslbeck, M Haslbeck, M Lis, M Martinez-Esparza, M Martinez-Esparza, M Ramsdale, M Ruhnke, M Werner-Washburne, MA Ramirez, MC Lorenz, MC Lorenz, MG Marcu, N Benaroudj, N Jaya, N Santoro, NA Gow, NA Gow, Neeraj Chauhan, O Zaragoza, O Zaragoza, P Ratnakar, P Van Dijck, Pedro Miramón, PK Sorger, PK Sorger, PL Fidel Jr, PW Piper, QT Phan, QT Phan, R Van Montfort, RA Calderone, RA Monge, RB Wilson, RE Susek, RS Shapiro, S Diamant, S Diamant, S Gola, S Hohmann, S Lindquist, S Lindquist, S Nicholls, S Nicholls, S Thewes, S Welker, SG Filler, SH Kaufmann, Silvia Slesiona, SJ Eyles, SL Elson, TF de Koning-Ward, VE Chester, Y Dubaquie, Y Zhu, YL Tsai, YL Tsai   +133 more
core   +4 more sources

Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function. Hypotheses and a comprehensive review [PDF]

, 2011
During the last decade, network approaches became a powerful tool to describe protein structure and dynamics. Here we review the links between disordered proteins and the associated networks, and describe the consequences of local, mesoscopic and global ...
Daniel V. Veres, Eszter Hazai, Federico Miozzo, Francesco Piazza, Huba J. M. Kiss, Kuljeet Singh Sandhu, Peter Csermely, Ruth Nussinov, Zsolt Hoksza   +8 more
core   +4 more sources

Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. [PDF]

, 2014
The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens.
Anastas, Sara, Basu, Subhasree, Brennan, Lisa A., Chauss, Daniel, Gau, Victoria, Hejtmancik, J. Fielding, Kantorow, Marc, Ma, Zhiwei, Menko, A. Sue, Rajakaruna, Suren   +9 more
core   +3 more sources

Analysis of the data on titration of native and peroxynitrite modified αA- and αB-crystallins by Cu2+-ions

Data in Brief, 2020
The interaction of αA- and αB-crystallins with Cu2+ ion modulates their structure and chaperone-like activity which is important for lens transparency. Theoretical analysis of the dependences of fluorescence intensity of native αA- and αB-crystallins and
Maryam Ghahramani, Reza Yousefi, Kazem Khoshaman, Sogand Sasan Moghadam, Boris Kurganov   +4 more
doaj   +1 more source

Heat shock proteins and the cellular response to osmotic stress [PDF]

, 2000
In antidiuresis, the intrarenal distribution of HSP25/27, alpha beta -crystallin, HSP72, OSP94 and HSP110 corresponds to the osmotic gradient between cortex and papilla: low amounts in the cortex and high values in the inner medulla and papilla.
Beck, Franz-X., Grünbein, Rita, Lugmayr, Karin, Neuhofer, Wolfgang   +3 more
core   +1 more source