Results 81 to 90 of about 43,221 (257)

Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1) [PDF]

, 2015
Heat shock protein 20 (HSP20) has cardioprotective qualities, which are triggered by PKA phosphorylation. PKD1 is also a binding partner for HSP20, and this prompted us to investigate whether the chaperone was a substrate for PKD1.
Baillie, George, Sin, Yuan Yan
core   +1 more source

CRYSTALLINE RIBONUCLEASE [PDF]

Journal of General Physiology, 1940
1. A crystalline enzyme capable of digesting yeast nucleic acid has been isolated from fresh beef pancreas. 2. The enzyme called "ribonuclease" is a soluble protein of albumin type. Its molecular weight is about 15,000. Its isoelectric point is in the region of pH 8.0. 3.
openaire   +2 more sources

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

HSPB4/CRYAA Protect Photoreceptors during Retinal Detachment in Part through FAIM2 Regulation

Neurology International
Our previous study discussed crystallin family induction in an experimental rat model of retinal detachment. Therefore, we attempted to evaluate the role of α-crystallin in photoreceptor survival in an experimental model of retinal detachment, as well as
Cagri G. Besirli, Madhu Nath, Jingyu Yao, Mercy Pawar, Angela M. Myers, David Zacks, Patrice E. Fort   +6 more
doaj   +1 more source

αB-crystallin mini-peptides support corneal healing in vitro and in vivo in rabbit model [PDF]

International Journal of Ophthalmology
AIM: To evaluate if topical use of αB-crystallin mini-peptides supports corneal healing following flap surgery. METHODS: Cultured corneal cells were treated with fluorescent tagged αB-crystallin mini-peptides to assess its internalization.
Namrata Maity, Aditya Konar, Sarbani Hazra   +2 more
doaj   +1 more source

Broccoli sprouts juice prevents lens protein aggregation in streptozotocin-induced diabetic rat [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate the effect of broccoli sprouts juice in preventing lens protein aggregation in diabetic rat model. METHODS: Totally 25 male Wistar rats were divided into negative control group, diabetic group without juice treatment as positive ...
Ayu Puspitasari, Nina Handayani
doaj   +1 more source

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

Into the Light: Diurnality has Evolved Multiple Times in Geckos [PDF]

, 2015
Geckos are the only major lizard group consisting mostly of nocturnal species. Nocturnality is presumed to have evolved early in gecko evolution and geckos possess numerous adaptations to functioning in low light and at low temperatures. However, not all
Bauer, Aaron M., Gamble, Tony, Greenbaum, E., Jackman, Todd R.   +3 more
core   +2 more sources

Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente, Isaac Ponce, Emmanuel Ríos‐Castro, Perla Moreno‐Castilla, Luis B. Tovar‐y‐Romo   +4 more
wiley   +1 more source

Celastrol regulates the oligomeric state and chaperone activity of αB-crystallin linked with protein homeostasis in the lens

Fundamental Research
Protein misfolding and aggregation are crucial pathogenic factors for cataracts, which are the leading cause of visual impairment worldwide. α-crystallin, as a small molecular chaperone, is involved in preventing protein misfolding and maintaining lens ...
Huaxia Wang, Qing Tian, Ying Zhang, Yibo Xi, Lidan Hu, Ke Yao, Jingyuan Li, Xiangjun Chen   +7 more
doaj   +1 more source