Results 301 to 310 of about 485,962 (354)

Photosensitizer Repositioning Affords an Enantiocomplementary Enzyme for [2 + 2]‐Cycloadditions

Angewandte Chemie International Edition, EarlyView.
In this study, we capitalize on the versatility offered by genetic code expansion to develop a proficient photoenzyme for [2 + 2]‐cycloadditions that is enantiocomplementary to our recently developed photoenzyme EnT1.3. By repositioning the genetically programmed benzophenone photosensitizer and subsequent directed evolution, we have developed an ...
Chuanjie Sun, Anna R. Kohn, Ross Smithson, Florence J. Hardy, Jonathan S. Trimble, Yuanxin Cao, Linus O. Johannissen, Sam Hay, Rebecca Crawshaw, Anthony P. Green   +9 more
wiley   +1 more source

Structural and biochemical differences between non-catalytic and catalytic antibodies. [PDF]

MAbs
Uda T, Kato R, Shigeta Y, Hirota S, Kobayashi J, Yoshida H, Tsuyuguchi M, Hengphasatporn K, Tsujita M, Taguchi H, Hifumi E.   +10 more
europepmc   +1 more source

Structural biology in variant interpretation: Perspectives and practices from two studies. [PDF]

Am J Hum Genet
Varga MJ, Richardson ME, Chamberlin A.
europepmc   +1 more source

Photo‐controlled Release of Urea Enables the Detection of Urea‐Urease Intermediates by cryo‐FTIR

Angewandte Chemie International Edition, Accepted Article.
Caged compounds are a valuable tool to photocontrol the release of enzymatic substrates in a reaction. For example, caged urea molecules were proposed to control urea delivery to urease reactions and aid the determination of the catalytic mechanism of this enzyme.
Caterina Netto, Sarah Bell, Caio B. Castro, Pedro Henrique Machado, Vatsal Purohit, Katherine M. Davis, Ana Paula L. Batista, R. Brian Dyer   +7 more
wiley   +1 more source

Code dependence of calculated crystalline electron densities. Possible lessons for quantum crystallography. [PDF]

IUCrJ
Landeros-Rivera B, Contreras-García J, Martín Pendás Á.   +2 more
europepmc   +1 more source

Multipoint Coordinative Capture of Olefinic Substrates Utilizing Metal‐Carbon Bonds by Macrocyclic Complex

Angewandte Chemie International Edition, Accepted Article.
Terpenoids and unsaturated fatty acids containing C=C double bonds are biologically and synthetically important compounds. The transformation of these substrates catalyzed by proteins relies on precise molecular capture. However, achieving precise molecular recognition of C=C double bonds using synthetically designed hosts remains a significant ...
Kohtaro Sugawara, Kenichiro Omoto, Takashi Nakamura   +2 more
wiley   +1 more source

Proton Occupancies in Histidine Side Chains of Carbonic Anhydrase II by Neutron Crystallography and NMR - Differences, Similarities and Opportunities. [PDF]

Chembiochem
Zoë Fisher S, Raum HN, Weininger U.
europepmc   +1 more source

IUCrJ on passing its tenth anniversary and entering its second decade: progress, current status and prospects for the future. [PDF]

IUCrJ
Allen AJ.
europepmc   +1 more source

Project automation in CCP4 Cloud: Enabling customization and high-throughput efficiency. [PDF]

Protein Sci
Krissinel E, Fando M, Kovalevskiy O, Keegan R, Wills J, Lebedev A, Uski V, Ballard C.   +7 more
europepmc   +1 more source