Results 141 to 150 of about 3,668 (161)

Genotypic diversity of CSFV field strains: A silent risk reduces vaccination efficacy of CSFV vaccines in Vietnam

Virology, 2022
Classical swine fever (CSF) is a highly contagious, devastating, and transboundary viral disease that afflicts swine industries worldwide. Immunization with vaccines is one of the most effective strategies for controlling this disease. However, shifts in the antigenicity and pathogenicity of novel evolving viral strains have the potential to evade ...
Ngoc Hai Nguyen, Phuong Binh Thi Nguyen, Trung Quan Nguyen, Duy Tien Do, My Duyen Thi Nguyen, Minh Nam Nguyen   +5 more
openaire   +2 more sources

Recombinant pseudorabies virus (PRV) expressing stabilized E2 of classical swine fever virus (CSFV) protects against both PRV and CSFV

Antiviral Research, 2023
Pseudorabies (PR) and classical swine fever (CSF) are economically important infectious diseases of pigs. Most pig farms in China are immunized against these two diseases. Here, we describe a stabilized E2 protein as an immunogen inserted into the PRV genome as a bivalent live virus-vectored vaccine.
Yang-yang Sun, Ke-shu Liu, Cun Zhang, Zheng Ni, Yin-chu Zhu, Hai-li Bao, Liu Chen, Wei-cheng Ye, Jiong-gang Hua, Su-xin Huo, Hong-yu Wang, Tao Yun, En-dong Bao   +12 more
openaire   +2 more sources

Recombinant pseudorabies virus expressing E2 of classical swine fever virus (CSFV) protects against both virulent pseudorabies virus and CSFV

Antiviral Research, 2020
Both classical swine fever (CSF) and pseudorabies are highly contagious, economically significant diseases of swine in China. Although vaccination with the C-strain against classical swine fever virus (CSFV) is widely carried out and severe outbreaks of CSF seldom occur in China, CSF is sporadic in many pig herds and novel sub-subgenotypes of CSFV ...
Wu, Tong, Hao, Zheng, Guo-Xin, Li, Fei, Gao, Tong-Ling, Shan, Yan-Jun, Zhou, Hai, Yu, Yi-Feng, Jiang, Ling-Xue, Yu, Li-Wei, Li, Ning, Kong, Guang-Zhi, Tong, Ji-Chang, Li   +12 more
openaire   +2 more sources

Broad neutralization of CSFV with novel monoclonal antibodies in vivo

International Journal of Biological Macromolecules, 2021
Classical swine fever is a highly contagious disease in China. Although vaccination against Classical swine fever virus (CSFV) has been widely carried out in China, CSFV cases still emerge in an endless stream. Therefore, it is necessary to take new antiviral measures to eliminate CSFV.
Huiling, Xu, Guangwei, Han, Ying, Lu, Zehui, Liu, Lina, Tao, Fang, He   +5 more
openaire   +2 more sources

Marker vaccine strategies and candidate CSFV marker vaccines

Vaccine, 2007
Classical swine fever (CSF) is an economically important highly contagious disease of swine worldwide. Classical swine fever virus (CSFV) is its etiological agent, and the only natural hosts are domestic pigs and wild boars. Although field CSFV strains vary in the virulence, they all result in serious losses in pig industry.
Xiao-Nan, Dong, Ying-Hua, Chen
openaire   +2 more sources

A capacitive surface stress biosensor for CSFV detection

Microelectronic Engineering, 2016
Capacitive biosensors are increasingly popular in biomedical analyses. In order to satisfy the requirements in medical diagnostics, such as high sensitivity and quick response, this paper presents a developed capacitive biosensor based on the surface stress to detect classical swine fever virus (CSFV) antigens.
Jianyan Tian, Yang Bai, Xiaoliang Tang, Shengbo Sang, Fang Wang   +4 more
openaire   +1 more source

The classic swine fever virus (CSFV) core protein can enhance de novo-initiated RNA synthesis by the CSFV polymerase NS5B

Virus Genes, 2014
Study of the classical swine fever virus (CSFV) replication is challenging because it is a BSL-3-Ag pathogen that requires specialized facilities. We developed a cell-based assay in human embryonic kidney 293T cells that can quantify the activities of NS5B, the CSFV RNA-dependent RNA polymerase.
Weiwei, Li, Yanming, Zhang, C Cheng, Kao
openaire   +2 more sources

Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase

Virus Research, 2009
Classical swine fever virus (CSFV) nonstructural protein 3 (NS3) is believed to possess three enzyme activities that are likely to be essential for virus replication: a serine protease located in the N-terminus and NTPase as well as helicase activities located in the C-terminus. In this report, we expressed NS3 helicase domain (NS3h) in E.
Guoyuan, Wen, Jinnuo, Xue, Yanping, Shen, Chuyu, Zhang, Zishu, Pan   +4 more
openaire   +2 more sources

MAVS induces a host cell defense to inhibit CSFV infection

Archives of Virology, 2018
Classical swine fever virus (CSFV) infection results in highly significant economic losses. Previous studies have suggested that CSFV can be recognized by RIG-I-like receptors (RLRs) to trigger innate defenses. However, the role of mitochondrial antiviral signaling protein (MAVS), the adaptor of RLRs, is still unknown during CSFV infection.
Wang, Dong, Huifang, Lv, Cheng, Li, Yaru, Liu, Chengbao, Wang, Jihui, Lin, Yifan, Wang, Gui, Qian, Kangkang, Guo, Yanming, Zhang   +9 more
openaire   +2 more sources

Chimeric (marker) C-strain viruses induce clinical protection against virulent classical swine fever virus (CSFV) and reduce transmission of CSFV between vaccinated pigs

Vaccine, 2001
Two live recombinant vaccines (Flc9 and Flc11) against classical swine fever (CSF) were evaluated for their capacity to reduce transmission of virulent CSF virus (CSFV) among vaccinated pigs. In Flc9 the 5' terminal half of the E2 gene of the C-strain, a CSFV vaccine strain, was exchanged with the homologous gene of the bovine viral diarrhoea virus ...
de Smit, A.J., Bouma, A., van Gennip, H.G., de Kluijver, E.P., Moormann, R.J.   +4 more
openaire   +2 more sources