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Genotypic diversity of CSFV field strains: A silent risk reduces vaccination efficacy of CSFV vaccines in Vietnam

Virology, 2022
Classical swine fever (CSF) is a highly contagious, devastating, and transboundary viral disease that afflicts swine industries worldwide. Immunization with vaccines is one of the most effective strategies for controlling this disease. However, shifts in the antigenicity and pathogenicity of novel evolving viral strains have the potential to evade ...
Ngoc Hai Nguyen   +5 more
openaire   +2 more sources

In vitro inhibition of CSFV replication by multiple siRNA expression

open access: yesAntiviral Research, 2011
Classical swine fever (CSF) is a highly contagious viral disease of pigs which causes major economic losses worldwide. No specific drug is currently available for the effective treatment of CSFV infection; however, RNA interference (RNAi) has been applied successfully to inhibit the replication of human and other animal viruses.
Tiedong Wang   +2 more
exaly   +3 more sources

Broad neutralization of CSFV with novel monoclonal antibodies in vivo

International Journal of Biological Macromolecules, 2021
Classical swine fever is a highly contagious disease in China. Although vaccination against Classical swine fever virus (CSFV) has been widely carried out in China, CSFV cases still emerge in an endless stream. Therefore, it is necessary to take new antiviral measures to eliminate CSFV.
Huiling, Xu   +5 more
openaire   +2 more sources

A capacitive surface stress biosensor for CSFV detection

Microelectronic Engineering, 2016
Capacitive biosensors are increasingly popular in biomedical analyses. In order to satisfy the requirements in medical diagnostics, such as high sensitivity and quick response, this paper presents a developed capacitive biosensor based on the surface stress to detect classical swine fever virus (CSFV) antigens.
Shengbo Sang
exaly   +2 more sources

Recombinant pseudorabies virus (PRV) expressing stabilized E2 of classical swine fever virus (CSFV) protects against both PRV and CSFV

Antiviral Research, 2023
Pseudorabies (PR) and classical swine fever (CSF) are economically important infectious diseases of pigs. Most pig farms in China are immunized against these two diseases. Here, we describe a stabilized E2 protein as an immunogen inserted into the PRV genome as a bivalent live virus-vectored vaccine.
Yang-yang Sun   +12 more
openaire   +2 more sources

Recombinant pseudorabies virus expressing E2 of classical swine fever virus (CSFV) protects against both virulent pseudorabies virus and CSFV

Antiviral Research, 2020
Both classical swine fever (CSF) and pseudorabies are highly contagious, economically significant diseases of swine in China. Although vaccination with the C-strain against classical swine fever virus (CSFV) is widely carried out and severe outbreaks of CSF seldom occur in China, CSF is sporadic in many pig herds and novel sub-subgenotypes of CSFV ...
Wu, Tong   +12 more
openaire   +2 more sources

Marker vaccine strategies and candidate CSFV marker vaccines

Vaccine, 2007
Classical swine fever (CSF) is an economically important highly contagious disease of swine worldwide. Classical swine fever virus (CSFV) is its etiological agent, and the only natural hosts are domestic pigs and wild boars. Although field CSFV strains vary in the virulence, they all result in serious losses in pig industry.
Xiao-Nan, Dong, Ying-Hua, Chen
openaire   +2 more sources

MAVS induces a host cell defense to inhibit CSFV infection

Archives of Virology, 2018
Classical swine fever virus (CSFV) infection results in highly significant economic losses. Previous studies have suggested that CSFV can be recognized by RIG-I-like receptors (RLRs) to trigger innate defenses. However, the role of mitochondrial antiviral signaling protein (MAVS), the adaptor of RLRs, is still unknown during CSFV infection.
Wang, Dong   +9 more
openaire   +2 more sources

Immune duration of a recombinant PRRSV vaccine expressing E2 of CSFV

Vaccine, 2020
Classical swine fever virus (CSFV) and Porcine reproductive and respiratory syndrome virus (PRRSV) are both important pathogens which seriously harm the economic swine industry worldwide. We have previously demonstrated that rPRRSV-E2 is a promising live, virus-vectored vaccine that provides 100% protection against highly pathogenic PRRSV (HP-PRRSV ...
Fei, Gao   +11 more
openaire   +2 more sources

Isolation and characterization of cytopathogenic classical swine fever virus (CSFV)

Archives of Virology, 1998
Two new classical swine fever virus (CSFV) isolates obtained from naturally infected swine were found to exhibit a cytopathogenic (cp) phenotype. According to their reactivity with monoclonal antibodies (mabs) the isolates cpBW1 and cpMVP1 were classified as antigenic types "Lothringen'92" and "Flandern'90", respectively.
A, Kosmidou, M, Büttner, G, Meyers
openaire   +2 more sources

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