Results 11 to 20 of about 2,252 (202)

Non-Isolated Dandy-Walker Malformation: Exome Sequencing Efficacy and Phenotypic Expansions. [PDF]

Clin Genet
Exome sequencing identified a diagnosis in 35% of 91 individuals with non‐isolated Dandy Walker malformation (DWM+). Only 24%–55% of these diagnoses could be made using a gene panel. We then demonstrated that DWM is a feature of disorders associated with ANKRD11, C2CD3, COL4A1, KMT2D, KRAS, OPHN1, SHOC2, SMARCB1, and WDR73.
Araji S, Zhao X, Rosenfeld JA, Lalani SR, Scott DA.   +4 more
europepmc   +2 more sources

Novel Lysosomal-Associated Transmembrane Protein 4B-Positive Stem-Like Cell Subpopulation Characterizes High-Risk Colorectal Cancer Subtypes. [PDF]

MedComm (2020)
This study identified the existence of a novel population of LAPTM4B+ tumor stem‐like cells in addition to the classical LGR5+ tumor stem‐like cells in colorectal cancer (CRC). The combination of LGR5+ and LAPTM4B+ stem‐like cells enable a more refined stratification of CRC, offering potential insights for targeted therapeutic strategies.
Fang Y, Fu T, Xiong Z, Zhang Q, Liu W, Yu K, Le A.   +6 more
europepmc   +2 more sources

Improving Bovine Embryo Development and Quality Using Bovine Oviductal Epithelial Cell-Derived Conditioned Medium (bOEC-CM). [PDF]

Vet Med Sci
The study investigated the effects of bOEC‐CM on bovine in vitro embryo development. CM from Day 3 enhances blastocyst rate and positively affects the ICM and TE in blastocysts and increases the expression of development‐specific genes. bOEC‐CM may serve as a superior supplement during the final five embryo culture days.
Hosseinabadi SK, Nazari H, Arabi M, Shams Esfandabadi N, Ahmadi E, Afzali A, Ghanaei H.   +6 more
europepmc   +2 more sources

Development and Validation of Pharmacology Concept Inventory for Concept-Based Learning: Leveraging Theory, Expert Insights, and Student Perspectives. [PDF]

Pharmacol Res Perspect
ABSTRACT Misconceptions in pharmacology can undermine learning and compromise both clinical and scientific reasoning, yet few validated tools exist to identify them. Consequently, we developed and validated the Pharmacology Concept Inventory (PCI), which can be used to identify misconceptions, assess learning gains, and evaluate teaching effectiveness.
Netere AK, Hughes T, Babey AM, Guilding C, Restini C, Hawes M, Kelly JP, Djouma E, Koenig J, McLaughlin JE, Olafuyi O, Fernandes LB, Mifsud J, Sills GJ, van Houwelingen AH, Tucker SJ, Liang W, Aronsson P, Khan FA, Hinton T, Hernandez M, Cormier L, Kelly-Laubscher R, Caetano Crowley FA, Santiago MJ, Cunningham M, Richardson JD, Karpa K, White PJ.   +28 more
europepmc   +2 more sources

Development of an Artificial Intelligence Powered Medication Risk Score Calculator Application. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT The publication explores the development of the Augmented Medication Risk Score (AUGMERIS) calculator, a web application supported by artificial intelligence, designed to automate the evaluation of medication therapies with the Danish Medication Risk Score (MERIS) method.
Bertalan Á, Angyal V, Domján P, Sædder EA, Király G, Erdélyi L, Gyimesi N, Dinya E.   +7 more
europepmc   +2 more sources

E-Variance: An Application to Assure Clinical Data Integrity and Improve Patient Safety and Workflows in Electronic Medical Records. [PDF]

Healthc Technol Lett
The RadOnc E‐Variance web‐based application, which is designed and developed to report data inconsistencies and variances noted during clinical operations. ABSTRACT Objective Ensuring critical data integrity practices are often missing from the confidence of decision‐making in the recorded clinical data.
Rahman S, Milman K, Lee TS.
europepmc   +2 more sources

Revolutionizing Infection Risk Scoring: An Ensemble “From Weak to Strong” Deduction Strategy and Enhanced Point‐of‐Care Testing Tools

Advanced Intelligent Systems, Volume 5, Issue 11, November 2023., 2023
This study explores challenges faced by human immunodeficiency virus patients during the COVID‐19 pandemic, aiming to develop a home‐based point‐of‐care testing (POCT) tool for early screening of acquired immunodeficiency syndrome coinfected with Talaromyces marneffei infection.
Haoman Chen, Hui Ye, Fanxuan Chen, Yi Shi, Jiahe Li, Yuhang Li, Chaoyi Wei, Chengxi Zhang, Jinhao Jin, Quanyue Zhang, Shuo Pan, Dong Chen, Shichao Quan, Xiaowei Xu, Zongxing Yang, Lijun Xu, Yungui Zhang, Yi Wang, Yunlong Zhou, Ou Liu, Xiaoming Jiang, Liyu Liu, Qingzu He, Xiaoqu Hu, Jingye Pan, Jianwei Shuai, Feifei Su   +26 more
wiley   +1 more source

VISUALIZAÇÃO DE AMBIENTES INTERNOS ATRAVÉS DE INTERATIVIDADE COMPUTACIONAL PROVIDA POR IMAGENS PANORÂMICAS

Colloquium Exactarum, 2016
Este trabalho apresenta uma maneira de visualizar e interagir em ambientes internos, utilizando sequências de imagens panorâmicas com posicionamento registrado no ambiente durante o percurso de deslocamento para realizar a captura.
Mateus Messias Cavichioli Coelho, Francisco Assis da Silva, Mário Augusto Pazoti, Danillo Roberto Pereira, Ricardo Luiz Barbosa, Rodrigo Bezerra de Araújo Gallis   +5 more
doaj   +5 more sources

Integration of EpiSign, facial phenotyping, and likelihood ratio interpretation of clinical abnormalities in the re‐classification of an ARID1B missense variant

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 193, Issue 3, September 2023., 2023
Abstract Heterozygous ARID1B variants result in Coffin–Siris syndrome. Features may include hypoplastic nails, slow growth, characteristic facial features, hypotonia, hypertrichosis, and sparse scalp hair. Most reported cases are due to ARID1B loss of function variants.
Caitlin Forwood, Katie Ashton, Ying Zhu, Futao Zhang, Kerith‐Rae Dias, Krystle Standen, Carey‐Anne Evans, Louise Carey, Michael Cardamone, Carolyn Shalhoub, Hala Katf, Carlos Riveros, Tzung‐Chien Hsieh, Peter Krawitz, Peter N Robinson, Tracy Dudding‐Byth, Bekim Sadikovic, Jason Pinner, Michael F. Buckley, Tony Roscioli   +19 more
wiley   +1 more source

LEVELNET to visualize, explore, and compare protein–protein interaction networks

PROTEOMICS, Volume 23, Issue 17, September 2023., 2023
Abstract Physical interactions between proteins are central to all biological processes. Yet, the current knowledge of who interacts with whom in the cell and in what manner relies on partial, noisy, and highly heterogeneous data. Thus, there is a need for methods comprehensively describing and organizing such data.
Yasser Mohseni Behbahani, Paul Saighi, Flavia Corsi, Elodie Laine, Alessandra Carbone   +4 more
wiley   +1 more source