Results 61 to 70 of about 3,326,582 (312)

Validation of OSEM algorithm for attenuation correction in cardiac SPECT studies [PDF]

, 2005
Photon attenuation is believed to be one of the major causes of artefacts in cardiac SPECT studies and therefore should be corrected to improve the specificity of cardiac SPECT imaging for the detection of coronary artery disease.
Alenezi, Ahmed M
core   +5 more sources

Prenatal stress alters amygdala functional connectivity in preterm neonates

NeuroImage: Clinical, 2016
Exposure to prenatal and early-life stress results in alterations in neural connectivity and an increased risk for neuropsychiatric disorders. In particular, alterations in amygdala connectivity have emerged as a common effect across several recent ...
Dustin Scheinost, Soo Hyun Kwon, Cheryl Lacadie, Gordon Sze, Rajita Sinha, R. Todd Constable, Laura R. Ment   +6 more
doaj   +1 more source

Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and 11C-UCB-J PET study

Frontiers in Human Neuroscience, 2023
Introduction: Resting-state network (RSN) connectivity is a widely used measure of the brain’s functional organization in health and disease; however, little is known regarding the underlying neurophysiology of RSNs.
Xiaotian T. Fang, Tommaso Volpi, Sophie E. Holmes, Irina Esterlis, Irina Esterlis, Richard E. Carson, Patrick D. Worhunsky   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Molecular imaging using positron emission tomography in gastrointestinal malignancy [PDF]

, 2010
Positron Emission Tomography (PET) with 18F-FDG has emerged as a powerful tool in oncology. Furthermore, recent advent of PET/CT and novel tracers are continually expanding its role.
Pakzad, F.
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16

Frontiers in Neurology, 2023
IntroductionSynapse loss is one of the hallmarks of Alzheimer's disease (AD) and is associated with cognitive decline. In this study, we tested [18F]SDM-16, a novel metabolically stable SV2A PET imaging probe, in the transgenic APPswe/PS1dE9 (APP/PS1 ...
Chao Zheng, Takuya Toyonaga, Baosheng Chen, LaShae Nicholson, William Mennie, Michael Liu, Joshua Spurrier, Kristin Deluca, Stephen M. Strittmatter, Richard E. Carson, Yiyun Huang, Zhengxin Cai   +11 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Molecular Imaging with Small Animal PET/CT

, 2011
: Small animal positron emission tomography (PET) and computer tomography (CT) is an emerging field in preclinical imaging. High quality, state-of-the-art instruments are required for full optimization of the translational value of the small animal ...
Jorgensen JT, Kjaer A., Jensen MM, AMBROSINI, VALENTINA, Skovgaard D, Binderup T, El Ali H, Li, Fan, Jørgensen, Jesper Tranekjær, Hesse, Birger, Birger Hesse, Skovgaard, Dorthe, Munk Jensen, Mette, Hesse, B., Ambrosini, V., Binderup, Tina, Andreas Kjær, Binderup, T., Fan Li, Kjær, Andreas, El Ali, Henrik H., Tina Binderup, Jensen, M.M., Jørgensen, J.T., Dorthe Skovgaard, Skovgaard, D., Kjær, A., Valentina Ambrosini, El-Ali, H.H., Henrik H. El-Ali, Mette Munk Jensen, Jesper Tranekjær Jørgensen   +31 more
core   +1 more source

A Practice Quality Improvement Project: Reducing Dose of Routine Chest CT Imaging in a Busy Clinical Practice [PDF]

, 2016
The purpose of this report is to describe our experience with the implementation of a practice quality improvement (PQI) project in thoracic imaging as part of the American Board of Radiology Maintenance of Certification process.
Takahashi, Edwin A., Kohli, Marc D., Teague, Shawn D., Kohli, Marc D, Takahashi, Edwin A, Teague, Shawn D   +5 more
core   +1 more source