Results 51 to 60 of about 244,114 (309)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Study on construction method of three-dimensional numerical model of coal with fracture structure

Meikuang Anquan
There are a large number of fracture structures with different forms in coal and rock mass, which indirectly affect and determine the mechanical properties of coal and rock mass.
Zixin ZHANG, Yang YU, Jiandong YU, Zengjie NIU, Ding LANG, Yao ZHANG   +5 more
doaj   +1 more source

Simulation study on artificial rock formation of deep coal seam roof sandstone

Meikuang Anquan, 2021
In order to study the similarities and differences of mechanical and internal fine view of the structure between artificial sandstone and deep coal seam roof sandstone, artificial sandstone of different material proportions and deep roof sandstone in No.
ZHAO Yang, ZHAO Shankun, ZHANG Ningbo, WANG Yin, LI Yunpeng, SU Zhenguo, QIN Kai, ZHAO Bin
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Microscopic experimental study on the heterogeneity and quantitative characterization of mineral grains and pore structures in coarse-grained glutenites

Meitan xuebao
The heterogeneity of rock is the essential reason for its nonlinear macroscopic mechanical properties under external forces. To study the degree of influence of mineral particles and pore structure on the heterogeneity of rock, coarse-grained glutenites ...
Shuai WANG, Ying XU, Yanbo ZHANG, Xulong YAO, Ling WANG   +4 more
doaj   +1 more source

Reconstruction and seepage simulation of coal and rock pore fracture structure based on CT imaging

Meikuang Anquan, 2021
In order to explore the seepage characteristics of coal seam pressure water injection under different permeability and fracture conditions, CT scanning technology was used to scan coal samples and obtain the original image. The noise points are filtered
LIU Weifu, DING Xuhai, ZHOU Guang
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

CT SCAN

The Professional Medical Journal, 2009
Objective: To study the diagnostic value of basal enhancement on computed tomography (CT scan) in differentiating tuberculous(TBM) from pyogenic (PM) meningitis. Design: Retrospective case control study. Setting: The Pediatric department in collaboration with thedepartment of Radiology and Diagnostic imaging of Bahawal Victoria hospital, Bahawalpur ...
ABDUL REHMAN, MOHAMMAD AMIN SHEIKH, MUSTANSAR MAHMOOD WARAICH   +2 more
openaire   +2 more sources

Evolution characteristics on coal fractures induced with CO2 phase transition fracturing based on CT scanning

矿业科学学报
This study conducted the CO2-PTF coal experiment to further reveal the fracturing transformation mechanism of CO2 phase transition fracturing(CO2-PTF)coal.
LIU Gaofeng, GUAN Wenbo, ZHANG Zhen, LI Baolin, LIU Huan, SI Nian   +5 more
doaj   +1 more source

Estudo dos níveis de referência de diagnóstico para procedimentos de tomografia computadorizada no estado de Santa Catarina [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2014.A Radiação Ionizante (RI) é conhecida por causar danos aos tecidos humanos e seu uso é cada ...
Savi, Matheus Brum Marques Bianchi
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