Scientific ReportsWe to measure the serum levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in patients diagnosed with connective tissue disease (CTD)-associated pulmonary arterial hypertension (PAH) (CTD-PAH) and to analyze ...
Xiaofei Shi +5 more
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BMC Complementary Medicine and Therapies, 2023 Background Cantharidin (CTD) is a major ingredient of cantharis (Mylabris phalerata Pallas) and has been used extensively in traditional Chinese medicines.
Jia Yan +6 more
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RRS James Clark Ross Cruises JR265 and JR254D, 27 Nov-24 Dec 2011. Part 1: The Drake Passage hydrographic repeat section SR1b [PDF]
, 2011 This report describes the 17th complete occupation of the Drake Passage CTD section, established during the World Ocean Circulation Experiment as repeat section SR1b. It wasfirst occupied by National Oceanography Centre (previously IOSDL and then SOC) in
et al,, Yelland, M.J.
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Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
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The clinical value of KL-6 for predicting the occurrence and severity of connective tissue disease-associated interstitial lung disease is not affected by CTD type or treatment [PDF]
PeerJObjective The aim of this study was to explore the potential values of Krebs von den Lungen-6 (KL-6), neutrophil to lymphocyte ratio (NLR), systemic immune inflammation (SII), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR) and red
Huifang Xing, Hongping Liang
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Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Advanced Science, EarlyView.Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
Chisholm’s Paradox Revisited: Puzzles regarding Contrary-to-Duty Obligations and a Dynamic Solution
Ergo, An Open Access Journal of Philosophy, 2021 A contrary-to-duty obligation (CTD obligation) is a type of conditional obligation that tells us what to do when a primary duty is violated. Chisholm’s Paradox is one of the most famous deontic puzzles about CTD obligations.
Yuna Won
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RRS Discovery Cruise D359, 17 Dec 2010-14 Jan 2011. RAPID moorings cruise report [PDF]
, 2011 This cruise report covers scientific operations conducted during RRS Discovery Cruise D359. Cruise D359 departed from São Antonio, Cape Verde on Friday 17th December 2010 arriving Santa Cruz de Tenerife Friday 14th December 2011.The purpose of the cruise
Cunningham, S.A., et al,
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The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain. [PDF]
, 2016 GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to the capillary lumen.
Beigneux, Anne P +9 more
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Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor
Advanced Science, EarlyView.Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang +4 more
wiley +1 more source