Results 131 to 140 of about 2,662 (167)

Fibroblasts as a ruler of the immune microenvironment: measurement and modulation in tissue homeostasis and disease. [PDF]

Front Immunol
Zhang Y, Fang X, Yan L, Wang L.
europepmc   +1 more source

Serum proteins associated with LDL-C and non-HDL-C reduction in response to dietary interventions in the DASH and DASH-Sodium trials.

Food Funct
Kim H, Lichtenstein AH, Coresh J, Appel LJ, Rebholz CM.   +4 more
europepmc   +1 more source

Cthrc1 is a positive regulator of osteoblastic bone formation

Cthrc1 is a positive regulator of osteoblastic bone formation
openaire  

Activated CTHRC1 promotes glycolysis in endothelial cells: Implications for metabolism and angiogenesis

Vascular Pharmacology, 2023
CTHRC1 is transiently expressed by activated fibroblasts during tissue repair and in certain cancers, and CTHRC1 derived from osteocytes is detectable in circulation. Because its biological activity is poorly understood, we investigated whether the N terminus of CTHRC1 encodes a propeptide requiring cleavage to become activated.
Igor Prudovsky, Volkhard Lindner
exaly   +3 more sources

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CTHRC1 expression in primary biliary cholangitis

Journal of Digestive Diseases, 2019
ObjectivesCollagen triple helix repeat containing‐1 (CTHRC1) is a highly conserved extracellular matrix glycoprotein that is overexpressed in two murine models of cholestatic liver fibrosis. Elevated CTHRC1 has been found to attenuate liver fibrosis in these murine models, thus we aimed to study the expression of CTHRC1 in patients with cholestatic ...
Yi Kang, Li, Yan Mei, Li, You, Li, Yi Ran, Wei, Jun, Zhang, Bo, Li, Zheng Rui, You, Yong, Chen, Bing Yuan, Huang, Qi, Miao, Qi Xia, Wang, Yan Shen, Peng, M Eric, Gershwin, Ru Qi, Tang, Zhao Lian, Bian, Xiong, Ma   +15 more
openaire   +2 more sources

The role and molecular mechanism of CTHRC1 in fibrosis

Life Sciences
Fibrosis, a pathological state characterized by the excessive accumulation of extracellular matrix components, is primarily driven by the overactivation of fibroblasts. This condition becomes particularly pronounced under chronic inflammatory conditions. Fibrosis can occur in several tissues throughout the body.
Mingzhen, Cao, Da, Ke, Heng, Zhou
openaire   +2 more sources

CTHRC1 Is Associated With Immune Escape and Poor Prognosis in Gastric Cancer

Anticancer Research, 2022
Collagen triple helix repeat containing-1 (CTHRC1) promotes tumor progression by regulating the immunosuppression of the tumor microenvironment. However, the function of CTHRC1 in gastric cancer (GC) and its relationship with tumor-infiltrating immune cells remains unclear.Data were downloaded from The Cancer Genome Atlas (TCGA) database.
Yangzhi, Hu, Lijuan, Huang, Kailai, Zhao, Yuan, Li, Nathan T, Givens, Aidan J, Heslin, Zuliang, Deng, Liequan, Cao, Yujiang, Fang   +8 more
openaire   +2 more sources

Cthrc1 overexpression is an independent prognostic marker in gastric cancer

Human Pathology, 2014
Collagen triple helix repeat containing 1 (CTHRC1) was identified as a novel gene expressed in the adventitia and neointima on arterial injury and was found to be overexpressed in several malignant tumors, such as breast cancer and malignant melanoma. However, the expression of Cthrc1 and its role in gastric cancer progression remain unknown.
Lina, Gu, Lei, Liu, Lili, Zhong, Yuxian, Bai, Hong, Sui, Xiaoli, Wei, Wenjie, Zhang, Peng, Huang, Dandan, Gao, Ying, Kong, Ge, Lou   +10 more
openaire   +2 more sources

CTHRC1 promotes bone metastasis in prostate cancer

International Journal of Cancer
AbstractProstate cancer causes a high frequency of bone metastases. The purpose of this study was to identify molecules that regulate prostate cancer bone metastasis as potential therapeutic and/or prognostic targets in prostate cancer, using integrative genome‐wide data.
Yuichiro Sawada, Tadahiko Kikugawa, Tomoya Onishi, Osuke Arai, Hiroyuki Iio, Noriyoshi Miura, Shuhei Yoshida, Aoi Ikedo, Yuta Yanagihara, Noritaka Saeki, Iori Sakakibara, Balázs Győrffy, Takeshi Kishida, Yoichiro Okubo, Yoshiyasu Nakamura, Shinya Sato, Yohei Miyagi, Takashi Saika, Yuuki Imai   +18 more
openaire   +2 more sources

SOX4 is a transcriptional activator for CTHRC1 in lung fibroblast activation

Gene
Collagen triple helix repeat containing 1(CTHRC1) has recently emerged as a hallmark of fibroblast activation in pulmonary fibrosis. However, the underlying transcriptional regulatory mechanisms remain incompletely understood. CTHRC1 and SRY-related HMG box transcription factor 4 (SOX4) were up-regulated and showed a positive correlation in fibrotic ...
Yuping Huang, Lulu Wu, Dandan Feng, Chenyu Zhang, Lili Zhuang, Rui Jin, Guoping Zhou   +6 more
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