Results 1 to 10 of about 436,571 (380)

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. [PDF]

Journal of Immunology, 1983
Three cell surface antigens associated with the cytolytic T lymphocyte(CTL)-target cell interaction were identified by generation of monoclonal antibodies (MAb) against OKT4+, HLA-DR-specific CTL and selection for inhibition of cytolysis in a 51Cr ...
Alan M. Krensky, Francisco Sánchez‐Madrid, E. Robbins, Janice A. Nagy, Timothy A. Springer, S J Burakoff   +5 more
openalex   +2 more sources

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. [PDF]

Journal of Immunology, 1995
Signals initiated through both the TCR complex and CD28 are required for optimal activation of T lymphocytes. Recently, it has been demonstrated that CD28 interacts with two different ligands, designated CD80 (B7/B7-1) and CD86 (B70/B7-2).
Lewis L. Lanier, S O'Fallon, Chamorro Somoza, Joseph H. Phillips, Peter S. Linsley, Ko Okumura, Daisuke Ito, Miyuki Azuma   +7 more
openalex   +2 more sources

Differentiation of Naive CTL to Effector and Memory CTL: Correlation of Effector Function with Phenotype and Cell Division [PDF]

Journal of Immunology, 1998
Phenotypically and functionally, the early steps of T cell differentiation are not well characterized. In addition, the effector T cell stage shares several phenotypic characteristics with memory T cells, which has made the analysis of T cell memory ...
Stephan Oehen, Karin Brduscha‐Riem
openalex   +2 more sources

Conditionally Active, pH-Sensitive Immunoregulatory Antibodies Targeting VISTA and CTLA-4 Lead an Emerging Class of Cancer Therapeutics

Antibodies, 2023
Immune checkpoints and other immunoregulatory targets can be difficult to precisely target due to expression on non-tumor immune cells critical to maintaining immune homeostasis in healthy tissues.
F. Donelson Smith, Robert H. Pierce, Thomas Thisted, Edward H. van der Horst   +3 more
doaj   +1 more source

Liver and Muscle Transcriptomes Differ in Mid-Lactation Cows Divergent in Feed Efficiency in the Presence or Absence of Supplemental Rumen-Protected Choline

Metabolites, 2023
Improving dairy cow feed efficiency is critical to the sustainability and profitability of dairy production, yet the underlying mechanisms that contribute to individual cow variation in feed efficiency are not fully understood.
Malia J. Caputo, Wenli Li, Sophia J. Kendall, Anna Larsen, Kent A. Weigel, Heather M. White   +5 more
doaj   +1 more source

بیان پری پلاسمیک یک دیابادی جدید برای هدف قرار دادن همزمان دو نقطه‌ی وارسی سیستم ایمنی PD-1 و CTLA-4 [PDF]

مجله دانشکده پزشکی اصفهان, 2023
مقاله پژوهشی مقدمه: مطالعات بالینی نشان داده است که مصرف همزمان دو مهارکننده‌ی مختلف نقاط وارسی ایمنی، نیولومب و ایپیلیمومب، به صورت معنی‌داری ایمنی و کارآیی درمانی بهتری در مقایسه با مصرف هر کدام به تنهایی داشته است.
مهسا بهزادی, وجیهه اکبری   +1 more
doaj   +1 more source

Polymorphisms Related to Iron Homeostasis Associate with Liver Disease in Chronic Hepatitis C

Viruses, 2023
Dysregulation of iron metabolism in chronic hepatitis C (CHC) is a significant risk factor for hepatic cirrhosis and cancer. We studied if known genetic variants related to iron homeostasis associate with liver disease progression in CHC.
Anna Wróblewska, Anna Woziwodzka, Magda Rybicka, Krzysztof P. Bielawski, Katarzyna Sikorska   +4 more
doaj   +1 more source

Combined Effects of Micro- and Nanoplastics at the Predicted Environmental Concentration on Functional State of Intestinal Barrier in Caenorhabditis elegans

Toxics, 2023
The possible toxicity caused by nanoplastics or microplastics on organisms has been extensively studied. However, the unavoidably combined effects of nanoplastics and microplastics on organisms, particularly intestinal toxicity, are rarely clear.
Yu Wu, Xiaochao Tan, Xian Shi, Peiyu Han, Huanliang Liu   +4 more
doaj   +1 more source

A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves

Marine Drugs, 2023
C-type lectins belong to a widely conserved family of lectins characterized in Metazoa. They show important functional diversity and immune implications, mainly as pathogen recognition receptors.
Amaro Saco, Hugo Suárez, Beatriz Novoa, Antonio Figueras   +3 more
doaj   +1 more source

Lighting Up the Fire in the Microenvironment of Cold Tumors: A Major Challenge to Improve Cancer Immunotherapy

Cells, 2023
Immunotherapy includes immune checkpoint inhibitors (ICI) such as antibodies targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) or the programmed cell death protein/programmed death ligand 1 (PD-1/PD-L1) axis.
Alice Benoit, Guillaume Vogin, Caroline Duhem, Guy Berchem, Bassam Janji   +4 more
doaj   +1 more source