Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source
Arming CTLs against immunosuppressors
Blood, 2009 Cell therapy efficacy after organ transplantation is hampered by the detrimental effects of pharmacologic immunosuppression on T-cell expansion and function. In this issue of Blood , 2 independent groups describe genetic engineering of ex vivo expanded EBV-CTLs to induce calcineurin-inhibitor resistance.
openaire +4 more sources
The origin of cytotoxic T lymphocyte precursors (CTL-P): MHC-restricted and alloreactive CTL-P in the spleen during regeneration after a sublethal dose of cyclophosphamide (Cy). [PDF]
, 1983 M Sihvola, Mikko Hurme
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Nanotherapy for Neural Retinal Regeneration
Advanced Science, EarlyView.Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu +11 more
wiley +1 more source
Pan‐Variant SARS‐CoV‐2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes
Advanced Science, EarlyView.An integrative approach identifies conserved B‐cell and T‐cell epitopes within SARS‐CoV‐2 proteins, redirecting immune responses from variable to conserved regions. These epitopes elicit robust humoral and cellular immunity, neutralizing diverse viral variants. Promiscuous T‐cell epitopes demonstrate cross‐species efficacy, highlighting their potential
Masaud Shah +5 more
wiley +1 more source
Geneticheskaya diagnostika rannikh markerov revmatoidnogo artrita
КардиоСоматика, 2015 Ревматоидный артрит (РА) по-прежнему относится к заболеваниям с неизвестной этиологией, в литературе широко дискутируется вопрос о его мультифакторной природе, в которой активное участие принимают генетические, внешнесредовые, иммунологические ...
Yu. V Fok +3 more
doaj
An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease. [PDF]
, 1994 Scott R. Burrows +3 more
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The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells
Advanced Science, EarlyView.RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp +5 more
wiley +1 more source
Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs. [PDF]
, 1994 Mutsunori Shirai +5 more
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