Results 131 to 140 of about 436,571 (380)

Reducing Validity in Epistemic ATL to Validity in Epistemic CTL

, 2013
We propose a validity preserving translation from a subset of epistemic Alternating-time Temporal Logic (ATL) to epistemic Computation Tree Logic (CTL). The considered subset of epistemic ATL is known to have the finite model property and decidable model-
Guelev, Dimitar P.
core   +2 more sources

Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes

Advanced Science, EarlyView.
This study demonstrates that SLC16A10 plays a crucial role in psoriasis pathogenesis through arachidonic acid metabolism regulation in keratinocytes. Using multi‐omics analysis and experimental validation, researchers identify SLC16A10 as both a diagnostic biomarker and therapeutic target.
Jingyuan Yang, Yixuan Chen, Bowei Li, Shuang Wu, Hang Liang, Xingyue Yang, Xiaozhen Li, Ping Sun, Guangjin Guo, Ting Li, Yuying Jia, Haijiao Li, Mengqi Bai, Jie Xu, Zhijie Liu, Wei Liu, Xiangkang Jiang, Hong Cai   +17 more
wiley   +1 more source

IgG4‐related retroperitoneal fibrosis induced by nivolumab and ipilimumab in a patient with non‐small cell lung cancer: A case report

Thoracic Cancer
IgG4‐related diseases are adverse events that occur after receiving treatment with immune checkpoint inhibitors (ICI). This study reports the first case of IgG4‐related retroperitoneal fibrosis after the administration of chemotherapy with nivolumab and ...
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana   +13 more
doaj   +1 more source

The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

eLife
Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities.
Robert J Bastidas, Mateusz Kędzior, Robert K Davidson, Stephen C Walsh, Lee Dolat, Barbara S Sixt, Jonathan N Pruneda, Jörn Coers, Raphael H Valdivia   +8 more
doaj   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Comprehensive Co-Inhibitory Receptor (Co-IR) Expression on T Cells and Soluble Proteins in Rheumatoid Arthritis

Cells
Co-inhibitory receptors (Co-IRs) are essential in controlling the progression of immunopathology in rheumatoid arthritis (RA) by limiting T cell activation.
Chin-Man Wang, Yeong-Jian Jan Wu, Li-Yu Huang, Jian-Wen Zheng, Ji-Yih Chen   +4 more
doaj   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Baricitinib attenuates pulmonary fibrosis in scleroderma mice by regulating macrophage polarization

陆军军医大学学报
Objective To determine whether baricitinib regulates macrophage polarization through Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway to reduce the severity of pulmonary fibrosis in mice with scleroderma.
WANG Dandan, XU Lulu, ZHANG Jie, ZHANG Jie   +3 more
doaj   +1 more source

Human alloreactive CTL clones: loss and reacquisition of specific cytolytic activity can be regulated by "recombinant" interleukin 2. [PDF]

, 1985
S L Wee, A C Ochoa, F H Bach
openalex   +1 more source

Maintenance of viral suppression in HIV-1–infected HLA-B*57+ elite suppressors despite CTL escape mutations

Journal of Experimental Medicine, 2006
Rare human immunodeficiency virus 1–infected individuals, termed elite suppressors (ES), maintain plasma virus levels of
J. Bailey, T. Williams, R. Siliciano, J. Blankson   +3 more
semanticscholar   +1 more source