Results 201 to 210 of about 436,571 (380)

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases [PDF]

, 1997
Apurva Sarin, Mark S. Williams, Martha A. Alexander‐Miller, Jay A. Berzofsky, Charles Zacharchuk, Pierre A. Henkart   +5 more
openalex   +1 more source

Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice.

Journal of Clinical Investigation, 2010
R. Ramakrishnan, D. Assudani, S. Nagaraj, T. Hunter, Hyun-Il Cho, S. Antonia, S. Altiok, E. Celis, D. Gabrilovich   +8 more
semanticscholar   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, EarlyView.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

Human Virus-Specific CD8+ CTL Clones Revert from CD45ROhigh to CD45RAhigh In Vivo: CD45RAhighCD8+ T Cells Comprise Both Naive and Memory Cells [PDF]

, 1999
Mark R. Wills, Andrew Carmichael, Michael P. Weekes, Kim Mynard, Georgina Okecha, Ray Hicks, J. G. P. Sissons   +6 more
openalex   +1 more source

Targeted Enrichment of Engineered Bacteria on Triple‐Negative Breast Cancer Turns Immunologically Cold Tumors Hot

Advanced Science, EarlyView.
In this study, an “all‐in‐one” engineered anaerobic bacterial system (PDAEcN/COS) is developed for the treatment of immunologically “cold” TNBC. This nanoplatform is capable of colonizing tumor cell surfaces and implementing “self‐blocking” of immune checkpoints, while simultaneously suppressing tumor cells' “don't eat me” signals and delivering “eat ...
Xuanxiang Zhai, Xiaoyi Shi, Xiao Liu, Xiaotong Gu, Wenting Li, Xiangjun Chen, Wei Hong   +6 more
wiley   +1 more source

A hsp70-2 Mutation Recognized by CTL on a Human Renal Cell Carcinoma [PDF]

, 1999
Catherine Gaudin, Florence Kremer, Eric Angevin, Véronique Scott, Frédéric Triebel   +4 more
openalex   +1 more source

The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL

Journal of Virology, 1996
M. Wills, A. Carmichael, Kim Mynard, Xiaomeng Jin, M. Weekes, B. Plachter, J. Sissons   +6 more
semanticscholar   +1 more source

CDK4/6 Inhibitor Priming Enhances PD‐1 Blockade via Sellhi Neutrophil‐Induced Stat5a+ Progenitor Exhausted CD8+ T Cell

Advanced Science, EarlyView.
Activated tumor‐intrinsic cyclin D1‐CDK4/6 signaling attenuates lymphocyte infiltration, and consequently, and immunotherapy resistance in HNSCC. It is discovered that brief CDK4/6i priming before anti‐PD‐1 results in enhanced durability of ICB response durability through Stat5a+ progenitor exhausted CD8+ T cells induced by IL15‐secreted Sell(hi ...
Yu Zhang, Bao Sun, Rong Zhou, Zizhen Gong, Yong Han, Wenjie Tao, Chaoji Shi, Wuchang Zhang, Laikui Liu, Zhiyuan Zhang, Jiang Li, Qi Zhu, Weiwen Zhu, Ziyue Gu   +13 more
wiley   +1 more source

In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8+ T cell epitopes. [PDF]

, 1996
Catherine Fayolle, Peter Šebo, Daniel Ladant, A Ullmann, Claude Leclerc   +4 more
openalex   +1 more source

Targeting of the CD161 Inhibitory Receptor Enhances Bone‐Marrow‐Resident Memory CD8+ T‐Cell‐Mediated Immunity against Multiple Myeloma

Advanced Science, EarlyView.
CD161 is identified as a novel inhibitory receptor on bone marrow (BM)‐resident CD8⁺ T cells in multiple myeloma (MM). Through interaction with its ligand CLEC2D, CD161 impairs T‐cell function and promotes immune suppression. Blockade of CD161 restores tissue residency and cytotoxicity of CD8⁺ T cells and enhances chimeric antigen receptor T‐cell (CAR ...
Liwen Wang, Linzhi Xie, Yi Zhou, Shiming Tan, Yan Yu, Qin Zhang, Xuefeng Chen, Yuhan Yan, Ruiheng Luo, Han Xiao, Qian Cheng, Jian Zhang, Ying Li, Erhua Wang, Tiebin Jiang, Jing Liu, Xin Li   +16 more
wiley   +1 more source