Results 231 to 240 of about 399,115 (333)

Design of Reading Materials based on Contextual Teaching and Learning (CTL)

, 2019
Atmazaki Atmazaki, Vivi Indriyani
openalex   +1 more source

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

Advanced Science, EarlyView.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian, Yun Chen, Jingyi Zhou, Shilin Zhang, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

CTL self-defence [PDF]

Nature Reviews Molecular Cell Biology, 2002
openaire   +2 more sources

PENGARUH PENERAPAN STRATEGI PEMBELAJARAN CONTEXTUAL TEACHING AND LEARNING (CTL) TERHADAP HASIL BELAJAR BATIK IKAT CELUP KELAS XI SMK NEGERI 1 BERASTAGI [PDF]

, 2018
Rohdearna Romasinta
openalex  

PENINGKATAN HASIL BELAJAR PESERTA DIDIK PADA MATA PELAJARAN TEKNOLOGI MEKANIK DENGAN MATERI MENGGUNAKAN ALAT-ALAT UKUR MELALUI PENERAPAN MODEL PEMBELAJARAN CONTEXTUAL TEACHING AND LEARNING (CTL) DI SMK NEGERI 2 KOTA BOGOR

, 2019
Ujang Hari
openalex   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

PENGGUNAAN METODE 3-IN-1 BERBANTUAN CTL UNTUK MENINGKATKAN KETERAMPILAN MEMBUAT POLA DASAR KONSTRUKSI PESERTA DIDIK KELAS X BUSANA 3 SMK NEGERI 6 SEMARANG

, 2019
Sri Murnisari
openalex   +2 more sources

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

Advanced Science, EarlyView.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen   +8 more
wiley   +1 more source

Cowpox Virus Protein CPXV012 Eludes CTLs by Blocking ATP Binding to TAP

, 2014
Rutger D. Luteijn, Hanneke Hoelen, Elisabeth Kruse, Wouter F. van Leeuwen, Jennine Grootens, Daniëlle Horst, Martijn C. Koorengevel, Jan W. Drijfhout, Elisabeth Kremmer, Klaus Früh, Jacques Neefjes, J. Antoinette Killian, Robert Jan Lebbink, Maaike E. Ressing, Emmanuel J. H. J. Wiertz   +14 more
openalex   +2 more sources