Results 121 to 130 of about 49,499 (264)

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

open access: yesThe FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano   +10 more
wiley   +1 more source

Length and Proximal Extent of Occlusion Dictates Severity of Disease in a Mini-Swine Model of PAD

open access: yesJVS - Vascular Science
Ali Hani Hakim   +9 more
doaj   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

open access: yesThe FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa   +1 more
wiley   +1 more source

Residency and Space Use of Endangered Smoothhound Sharks (Mustelus mustelus) in Relation to Marine Protection and Demersal Longline Fishing Along South Africa's South Coast

open access: yesFisheries Management and Ecology, EarlyView.
ABSTRACT Shark populations are declining globally and the effectiveness of marine protected areas (MPAs) as a conservation tool may vary by species and environmental context. This study assessed space use and residency of smoothhound sharks (Mustelus mustelus)—an endangered, yet highly exploited shark—in relation to spatial protection and fishing risk ...
Eugin Bornman   +3 more
wiley   +1 more source

Myeloid Cell Lgr4 Contributes to Atherosclerotic Lesion Formation

open access: yesJVS - Vascular Science
Ishita Kathuria   +7 more
doaj   +1 more source

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