Results 111 to 120 of about 48,872 (261)

CTR MEETS REALITY [PDF]

Journal of Neurology and Neuromedicine, 2018
openaire   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Post‐Release Mortality of European Bass (Dicentrarchus labrax) Discarded From Small‐Scale Estuarine Fishing

Fisheries Management and Ecology, EarlyView.
ABSTRACT Estuaries provide essential habitats for many fish species, but their confined and accessible nature may increase fish vulnerability to capture, and few empirical studies have quantified the value of restricting net fisheries in such areas.
J. E. Stewart, T. Stamp, P. Davies, A. Hall, T. Robbins, L. Stewart, E. V. Sheehan   +6 more
wiley   +1 more source

The Impact of Periodontitis on Oral Health Outcomes in Older Adults: A Systematic Review

Gerodontology, EarlyView.
ABSTRACT Objective To systematically review the impact of periodontitis on clinical oral health outcomes and oral health‐related quality of life (OHRQoL) in older adults (≥ 60 years). Background Global evidence shows that severe periodontitis prevalence peaks in the 60s, yet how periodontitis relates specifically to oral health outcomes in older adults
Lewis Winning, Kristina Bertl, Ioannis Polyzois, Yvonne Van der Waal, Rawan Kahatab, Peter Harrison, Gerry McKenna   +6 more
wiley   +1 more source

Endoscopic Versus Open Carpal Tunnel Release in Obese and Nonobese Patients. [PDF]

J Hand Surg Glob Online
Salib A, Sanchez JG, Diatta F, Zehner KM, Kong V, Grauer JN, Colen D.   +6 more
europepmc   +1 more source

Accelerating Platform User Growth: Pinduoduo's Multi‐Motivational Selfish Referral Strategy

Information Systems Journal, EarlyView.
ABSTRACT Referral strategies, whereby existing platform users recruit new users and thereby strengthen same‐side network effects, have long been central to digital platforms' efforts to grow the installed user base. Current referral strategies often require the referee to complete a transaction as a prerequisite for the referrer to receive the reward ...
Runyu Shi, Panos Constantinides, Federico Iannacci   +2 more
wiley   +1 more source

Structural mechanism of SAM-AMP and SAM-AMP₂ synthesis by the type III-D2 CRISPR effector complex. [PDF]

Nat Commun
Mitsuda Y, Sugaya M, Ishikawa J, Nagahata N, Okazaki S, Hiraizumi M, Kato K, Gootenberg JS, Abudayyeh OO, Osawa T, Yamashita K, Nishimasu H.   +11 more
europepmc   +1 more source

Dapagliflozin does not impair microvascular hemorheology in type 2 diabetes mellitus: A multicenter randomized controlled trial (D‐PATH study)

Journal of Diabetes Investigation, EarlyView.
Graphical abstract illustrating the study design, physiological rationale, and key findings of the D‐PATH trial. Dapagliflozin, an SGLT2 inhibitor, lowers HbA1c and body weight while increasing hematocrit and erythropoietin levels. Although an elevated hematocrit could theoretically increase blood viscosity and impair microcirculatory flow, ex vivo ...
Yuki Nakatani, Nobuyuki Banba, Shoya Ono, Tomoki Turumi, Megumi Hoshiai, Takushi Sugiyama, Takashi Tomoe, Hajime Tamiya, Naoyuki Otani, Hiroyuki Sugimura, Hidekazu Ikemiyagi, Yusuke Ohya, Koji Yokokawa, Shinichiro Ueda, Yoshimasa Aso, Yasuhiro Maejima, Takanori Yasu   +16 more
wiley   +1 more source

Accuracy of Contemporary Intraocular Lens Calculation Formulas Based on Swept-Source OCT Biometry in Eyes with Capsular Tension Ring. [PDF]

Turk J Ophthalmol
Devebacak A, Yılmaz M, Arıkan G.
europepmc   +1 more source