Novel CTRP8-RXFP1-JAK3-STAT3 axis promotes Cdc42-dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells [PDF]
Molecular Oncology, 2022 C1q tumor necrosis factor‐related peptide 8 (CTRP8) is the least studied member of the C1Q‐TNF‐related peptide family. We identified CTRP8 as a ligand of the G protein‐coupled receptor relaxin family peptide receptor 1 (RXFP1) in glioblastoma multiforme (
Sabine Hombach-Klonisch +2 more
exaly +5 more sources
C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma [PDF]
Molecular Oncology, 2018 The C1q/TNF‐related peptide 8 (CTRP8) has recently emerged as a novel ligand of the G protein‐coupled receptor RXFP1 in the fatal brain tumor glioblastoma (GBM). We previously demonstrated that the CTRP8‐RXFP1 ligand–receptor system promotes motility and
Guo-Jun Zhang +2 more
exaly +5 more sources
C1q/TNF-Related Proteins 1, 6 and 8 Are Involved in Corneal Epithelial Wound Closure by Targeting Relaxin Receptor RXFP1 In Vitro [PDF]
International Journal of Molecular Sciences, 2023 Inadequate wound healing of ocular surface injuries can lead to permanent visual impairment. The relaxin ligand-receptor system has been demonstrated to promote corneal wound healing through increased cell migration and modulation of extracellular matrix
Friedrich Paulsen +2 more
exaly +4 more sources
RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer [PDF]
Frontiers in Endocrinology, 2015 The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ...
Thatchawan eThanasupawat +6 more
doaj +4 more sources
Identification of CTRP1 as a Prognostic Biomarker and Oncogene in Human Glioblastoma. [PDF]
Biomed Res Int, 2019 Introduction. Glioblastoma (GBM) is the most frequent and malignant type of primary brain tumors in adults. The valuable prognostic biomarkers and therapeutic targets for GBM remain to be elucidated. The association of adipokines with cancer has been well documented.
Chen L, Su G.
europepmc +2 more sources
A Six-Gene Signature Predicts Survival of Adenocarcinoma Type of Non-Small-Cell Lung Cancer Patients: A Comprehensive Study Based on Integrated Analysis and Weighted Gene Coexpression Network. [PDF]
Biomed Res Int, 2019 Background and Goals. To identify a multigene signature model for prognosis of non‐small‐cell lung cancer (NSCLC) patients, we first found 2146 consensus differentially expressed genes (DEGs) in NSCLC overlapped in Gene Expression Omnibus (GEO) and TCGA lung adenocarcinoma (LUAD) datasets using integrated analysis.
Xie H, Xie C.
europepmc +2 more sources
Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells [PDF]
British Journal of Pharmacology, 2017 Sabine Hombach-Klonisch +2 more
exaly +2 more sources
New antisera specific for human C1Q-TNF-related protein 8 (CTRP8): characterization and tissue distribution [PDF]
, 2021 Introduction: Adiponectin and the structurally related C1Q-Tumor Necrosis Factor-related proteins (CTRP) have important roles in innate immunity and metabolism. CTRP8 is the most recently discovered and least characterized member of this family.
Krishnan, Sai Nivedita
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Photoinduced electron transfer processes of single‐wall carbon nanotube (SWCNT)–based hybrids
Nanophotonics, Volume 9, Issue 16, Page 4689-4701, June 2018., 2018 Abstract In this review, noncovalent functionalization of single‐wall carbon nanotubes (SWCNTs) is briefly reviewed. The functional materials summarized here include metalloporphyrin derivatives, biomolecules and conjugated polymers. Notably, time‐resolved spectroscopic techniques such as time‐resolved fluorescence and transient absorption were ...
Lili Du +3 more
wiley +1 more source
Investigating a novel CTRP8-DLK1 interaction and its impact on glioma stemness
, 2023 Background: The C1Q-tumor necrosis factor related protein (CTRP) family has functions in metabolism, immunity, and cancer. Among the CTRP family, CTRP8 remains the least well characterized in terms of function and receptors.
Arreza, Leanne
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