The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
Molecular Genetics & Genomic Medicine, 2020 Background Relaxin/relaxin family peptide receptor 1 (RXFP1) signaling is important for both normal physiology and disease. Strong preclinical evidence supports relaxin as a potent antifibrotic molecule.
Ching-Hsia Hung +2 more
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Antioxidants, 2023 Due to the high incidence of diabetes mellitus (DM) and poor response to the first-line treatment of DM-induced erectile dysfunction (DMED), new therapeutic strategies for DMED are needed.
Wenchao Xu, Yang Luan, Jihong Liu
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Expression of relaxin-3 and its receptors in the hypothalamic-pituitary-ovary axis in layers and broiler breeders [PDF]
Poultry ScienceLayers can regulate their feed intake and maintain well-organized ovaries. Conversely, broiler breeders are prone to overeating, leading to disorganized ovaries.
Kahina Boukherroub +5 more
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Isoviolanthin suppresses IL-1β-induced inflammatory and catabolic responses in chondrocytes [PDF]
Frontiers in PharmacologyBackgroundKnee osteoarthritis (KOA) is characterized by the progressive degeneration of articular cartilage, necessitating novel therapeutic strategies to halt disease progression. Isoviolanthin, a natural flavonoid glycoside, has an unclear mechanism of
Jian-Li Yin +10 more
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Immune cell uptake of glycinated nanoparticles conjugated to anti-fibrotic peptides enables their prolonged activity and oral administration [PDF]
Journal of Biomedical ScienceBackground Fibrosis is a hallmark of various chronic diseases, for which there is no effective cure. Whilst the recombinant form of the human peptide hormone, relaxin (RLX), is being clinically evaluated for its cardioprotective including anti-fibrotic ...
Deidree V. N. Somanader-Livera +9 more
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Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats [PDF]
Fluids and Barriers of the CNSOxidative stress and neuronal apoptosis could be an important factor leading to post-hemorrhagic consequences after germinal matrix hemorrhage (GMH). Previously study have indicated that relaxin 2 receptor activation initiates anti-oxidative stress and ...
Jun Liu +13 more
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Structural insights into G protein-coupled receptor signaling [PDF]
Structural DynamicsG protein-coupled receptors (GPCRs) are the largest single family of transmembrane proteins encoded in the human genome, and they are among the most successful classes of therapeutic drug targets of all time.
Andrew Kruse
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Expression of Relaxin Family Peptide Receptors 1 and 3 in the Ovarian Follicle of Japanese Quail [PDF]
The Journal of Poultry ScienceIn our previous studies, we demonstrated that the primary source of relaxin 3 (RLN3) in Japanese quail is ovarian granulosa cells. Although several relaxin family peptide (RXFP) receptors have been sequenced, the intricacies of these receptors in avian ...
Khoi X. Hoang +3 more
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Spatial-temporal regulation of the prostanoid receptor EP2 co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium [PDF]
iScienceSummary: Decidualization denotes the differentiation of endometrial stromal cells into specialized decidual cells, essential for embryo implantation and pregnancy.
Paul J. Brighton +7 more
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تاثیر پنج هفته تمرین تناوبی شدید بر بیان ژن‌های RXFP1 و CTGF بافت قلبی و آنزیم کبدی SGPT در رت‌های ویستار نر مبتلا به کبد چرب [PDF]
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad., 2022 زمینه و هدف: در سالهای اخیر مطالعاتی درموردارتباط کبدچرب و آتروسکلروزیس انجام شده است که نتایج این مطالعات، حاکی از ارتباط کبد چرب غیرالکلی با آترواسکلروزیس عروق کرونری می باشد. کبد چرب با افزایش خطر بیماریهای قلبی- عروقی همراهی دارد.
مسعود حمزه لو +2 more
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