Results 11 to 20 of about 1,276 (166)
ML290 is a biased allosteric agonist at the relaxin receptor RXFP1 [PDF]
Scientific Reports, 2017 Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability.
Martina Kocan +11 more
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In a Class of their own – RXFP1 and RXFP2 are unique members of the LGR family [PDF]
Frontiers in Endocrinology, 2015 The leucine-rich repeat-containing G protein-coupled receptors (LGRs) family consists of three groups: type A, B and C and all contain a large extracellular domain made up of the structural motif – the leucine rich repeat.
Emma June Petrie +9 more
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Relaxin-2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat. [PDF]
FASEB JCardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Vázquez-Abuín X +11 more
europepmc +2 more sources
PLoS ONE, 2021 Relaxin/insulin-like family peptide receptor 1 (RXFP1) mediates relaxin's antifibrotic effects and has reduced expression in the lung and skin of patients with fibrotic interstitial lung disease (fILD) including idiopathic pulmonary fibrosis (IPF) and ...
Ting-Yun Chen +9 more
doaj +2 more sources
The relaxin receptor RXFP1 signals through a mechanism of autoinhibition [PDF]
Nature Chemical Biology, 2022 Abstract The relaxin family peptide receptor 1 (RXFP1) is the receptor for relaxin-2, an important regulator of reproductive and cardiovascular physiology. RXFP1 is a multi-domain G protein-coupled receptor (GPCR) with an ectodomain consisting of an LDLa module and leucine-rich repeats.
Erlandson, Sarah +10 more
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Molecular Oncology, 2022 C1q tumor necrosis factor‐related peptide 8 (CTRP8) is the least studied member of the C1Q‐TNF‐related peptide family. We identified CTRP8 as a ligand of the G protein‐coupled receptor relaxin family peptide receptor 1 (RXFP1) in glioblastoma multiforme (
Aleksandra Glogowska +5 more
doaj +1 more source
PAIN Reports, 2021 . Introduction:. The relaxin peptide signaling system is involved in diverse physiological processes, but its possible roles in the brain, including nociception, are largely unexplored. Objective:.
Cynthia Abboud +6 more
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Scientific Reports, 2022 Despite beneficial effects in acute heart failure, the full therapeutic potential of recombinant relaxin-2 has been hampered by its short half-life and the need for intravenous administration limiting its use to intensive care units.
Stephane Illiano +23 more
doaj +1 more source
The effect of high intensity interval training on CTGF and RXFP1 genes expression of heart tissue and SGPT liver enzyme in rats with fatty liver [PDF]
Journal of Exercise & Organ Cross Talk, 2022 This study investigated the effect of high intensity interval training on CTGF and RXFP1 genes expression of heart tissue and SGPT liver enzyme in rats with fatty liver.
Masoud Hamzehloo, Mania Roozbayani
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Relaxin/RXFP1 Signaling in Prostate Cancer Progression [PDF]
Annals of the New York Academy of Sciences, 2009 We found that relaxin peptide expression is significantly elevated in recurrent human prostate cancer. Stimulation with relaxin increased migration, invasiveness, proliferation, and adhesion of LNCaP and PC3 cells in vitro. Opposite effects on cellular phenotype were observed after suppression of endogenous relaxin/RXFP1 expression or signaling.
Shu, Feng +7 more
openaire +2 more sources