Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension [PDF]
Scientific ReportsHypertension remains a leading cause of cardiovascular and kidney diseases. Failure to control blood pressure with ≥ 3 medications or control requiring ≥ 4 medications is classified as resistant hypertension (rHTN) and new therapies are needed to reduce ...
Xin Wang, Steven Pitts, Joseph Foley
exaly +5 more sources
Evolutionary relaxation and functional change of INSL3 and RXFP2 may underlie natural cryptorchidism in mammals [PDF]
EMBO ReportsCryptorchidism is a common congenital abnormality that increases infertility and testicular cancer risk in adulthood. However, a few mammals exhibit naturally undescended testes while maintaining normal reproduction.
Yu Zheng +6 more
doaj +5 more sources
Functional Characterization of IGF2BP1, CDC25A, and RXFP2 Genes: Implications for Ovarian Function and Reproductive Regulation in Goats [PDF]
AnimalsGoat reproductive performance is a key determinant of the productivity and economic value of goat farming, especially in meat and milk production.
Haiyan Yang +8 more
doaj +2 more sources
Spermatic RXFP2 expression levels and seminal INSL3 concentrations among beef bull ejaculates with different levels of sperm morphological normality [PDF]
The Journal of Reproduction and DevelopmentThe objective of this study was to examine the relationship between the insulin-like peptide 3 (INSL3) receptor (RXFP2) expression levels on spermatozoa and INSL3 concentrations in the seminal plasma of fresh semen from beef bulls with different levels ...
Hewage Dilhan Anuradha WIMALARATHNE +6 more
doaj +2 more sources
Environment International, 2020 Background: The presence of chemical pollutants in the environment can affect human health. Epidemiological and in vivo experimental studies reveal reprotoxic effects (undescended testis) of phthalates (diethylhexyl phthalate (DEHP), dibutyl phthalate ...
Mathilde Munier +2 more
exaly +3 more sources
Screening of molecular markers associated with hornless traits in Qira black sheep [PDF]
BMC GenomicsHornless trait in sheep is one of the important traits affecting their economic production efficiency. In order to screen the molecular markers related to hornless trait in Qira black sheep, we used Illumina Ovine 50 K SNP chip data of 189 Qira black ...
Wen Zhou +11 more
doaj +2 more sources
Analysis of genetic variants for different horn phenotypes and their inheritance in Icelandic sheep [PDF]
Archives Animal BreedingIcelandic sheep are characterized by a great diversity in horn phenotypes. Within their breed, they show a variability in terms of this trait to an extent rarely observed elsewhere.
R. Simon +2 more
doaj +2 more sources
Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep [PDF]
AnimalsThe types and morphology of sheep horns have been extensively researched, yet the genetic foundation underlying the emergence of diverse horn characteristics during the breeding of polled Tibetan sheep has remained elusive.
Dehong Tian +5 more
doaj +2 more sources
The Development of Horns in Bovidae and the Genetic Mechanisms Underpinning This Process [PDF]
BiologyHorns in Bovidae, including bovines, sheep, and goats, are evolutionarily conserved cranial structures derived from cranial neural crest cells and composed of a bony core, dermis, epidermis, and keratinous sheath.
Xiaoli Xu +5 more
doaj +2 more sources
RXFP2-positive mesenchymal stem cells in the antlerogenic periosteum contribute to postnatal development of deer antlers [PDF]
Communications BiologyThe postnatal development of secondary sexual characteristics is a highly complex process governed by diverse molecular signals and serves as a key marker of sexual maturity.
Hengxing Ba +8 more
doaj +2 more sources