Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension [PDF]
Scientific ReportsHypertension remains a leading cause of cardiovascular and kidney diseases. Failure to control blood pressure with ≥ 3 medications or control requiring ≥ 4 medications is classified as resistant hypertension (rHTN) and new therapies are needed to reduce ...
Xin Wang, Steven J Pitts
exaly +3 more sources
Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques [PDF]
Reproductive Biology and Endocrinology, 2010 Background Although insulin-like 3 (INSL3) has been identified in the gonad of both sexes in many species, there are only limited reports on the distribution of INSL3 and its receptor, relaxin/insulin-like family peptide receptor 2 (RXFP2), in the ...
Jensen Jeffrey T +4 more
doaj +2 more sources
Spermatic RXFP2 expression levels and seminal INSL3 concentrations among beef bull ejaculates with different levels of sperm morphological normality [PDF]
The Journal of Reproduction and DevelopmentThe objective of this study was to examine the relationship between the insulin-like peptide 3 (INSL3) receptor (RXFP2) expression levels on spermatozoa and INSL3 concentrations in the seminal plasma of fresh semen from beef bulls with different levels ...
Hewage Dilhan Anuradha WIMALARATHNE +6 more
doaj +2 more sources
Environment International, 2020 Background: The presence of chemical pollutants in the environment can affect human health. Epidemiological and in vivo experimental studies reveal reprotoxic effects (undescended testis) of phthalates (diethylhexyl phthalate (DEHP), dibutyl phthalate ...
Valentine Suteau +2 more
exaly +3 more sources
Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep. [PDF]
Adv Sci (Weinh)The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Liu Z +12 more
europepmc +2 more sources
Evolutionary relaxation and functional change of INSL3 and RXFP2 may underlie natural cryptorchidism in mammals [PDF]
EMBO ReportsCryptorchidism is a common congenital abnormality that increases infertility and testicular cancer risk in adulthood. However, a few mammals exhibit naturally undescended testes while maintaining normal reproduction.
Yu Zheng +6 more
doaj +2 more sources
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2 [PDF]
Communications Biology, 2022 Specific small molecule RXFP2 agonists with favorable pharmacokinetic properties induce gubernacular invagination in mouse embryos, increase mineralization activity in human osteoblasts in vitro, and improve bone trabecular parameters in adult mice.
Maria Esteban-Lopez +17 more
doaj +2 more sources
Expression and function of G-protein-coupled receptorsin the male reproductive tract [PDF]
Anais da Academia Brasileira de Ciências, 2009 This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract.
Maria Christina W. Avellar +2 more
doaj +5 more sources
Frontiers in Endocrinology, 2013 Relaxin family peptide (RXFP) receptors 1 and 2 are unique G-protein coupled receptors in that they contain an N-terminal low density lipoprotein type A (LDLa) module which is necessary for receptor activation.
Shoni Bruell, Bradley Hoare, John D Wade
exaly +3 more sources
Identification of Critical Genes for Ovine Horn Development Based on Transcriptome during the Embryonic Period [PDF]
Biology, 2023 Horns, also known as headgear, are a unique structure of ruminants. As ruminants are globally distributed, the study of horn formation is critical not only for increasing our understanding of natural and sexual selection but also for the breeding of ...
Yuanyuan Luan +7 more
doaj +2 more sources