The Development of Horns in Bovidae and the Genetic Mechanisms Underpinning This Process [PDF]
BiologyHorns in Bovidae, including bovines, sheep, and goats, are evolutionarily conserved cranial structures derived from cranial neural crest cells and composed of a bony core, dermis, epidermis, and keratinous sheath.
Xiaoli Xu +5 more
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Functional Characterization of IGF2BP1, CDC25A, and RXFP2 Genes: Implications for Ovarian Function and Reproductive Regulation in Goats [PDF]
AnimalsGoat reproductive performance is a key determinant of the productivity and economic value of goat farming, especially in meat and milk production.
Haiyan Yang +8 more
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The structural determinants of insulin-like peptide 3 activity [PDF]
Frontiers in Endocrinology, 2012 INSL3 is a hormone and/or paracrine factor which is a member of the relaxin peptide family. It has key roles as a fertility regulator in both males and females. The receptor for INSL3 is the leucine rich repeat (LRR) containing G-protein coupled receptor
Ross AD Bathgate +5 more
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Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat [PDF]
Reproductive Biology and Endocrinology, 2007 Background Relaxin is the endogenous ligand of the G-protein coupled receptor RXFP1, previously known as LGR7. In humans relaxin can also activate, but with lower affinity, the closely related receptor for the insulin-like peptide from Leydig cells ...
Porto Catarina S +6 more
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Expression and localization of RLF/ INSL3 receptor RXFP2 in boar testes
Italian Journal of Anatomy and Embryology, 2014 This study investigated the possibility of the presence of specific receptor for relaxin-like factor (RLF)/insulin-like peptide 3 (INSL3) in boar testes. While RLF/INSL3 was produced by Leydig cells in the boar testis, its own receptor RXFP2 was expressed mainly in meiotic and post-meiotic germ cells, but not in Leydig cells, suggesting the existence ...
Tetsuya, Kohsaka +10 more
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Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next. [PDF]
Mov DisordAbstract Knowledge of the genetic factors in normal pressure hydrocephalus (NPH) is rapidly evolving, with significant advances in recent years. We conducted a systematic review examining genetic contributions to NPH risk. Ovid Embase, Ovid Medline, Web of Science, and Cochrane Central were searched from inception through October 14, 2024, for human ...
Piccinin CC +9 more
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A 1.8‐kb insertion in the 3′‐UTR of RXFP2 is associated with polledness in sheep [PDF]
Animal Genetics, 2015 Sheep breeds show a broad spectrum of different horn phenotypes. In most modern production breeds, sheep are polled (absence of horns), whereas horns occur mainly in indigenous breeds. Previous studies mapped the responsible locus to the region of the RXFP2 gene on ovine chromosome 10.
Wiedemar, Natalie, Drögemüller, Cord
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Changes in Knee Laxity and Relaxin Receptor Isoforms Expression (RXFP1/RXFP2) in the Knee throughout Estrous Cycle Phases in Rodents. [PDF]
PLoS ONE, 2016 The changes in knee laxity and relaxin receptor expression at different phases of rodent estrous cycle are not known. Here, changes in the parameter were investigated in rats at different phases of the estrous cycle. Estrous cycle phases of intact female
Firouzeh Dehghan +6 more
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Insulin-like peptide 3 is not a biomarker for pancreatic ductal adenocarcinoma [PDF]
Frontiers in EndocrinologyPancreatic ductal carcinoma (PDAC) is a rapidly growing cancer with a very poor prognosis. It is, therefore, important to develop novel, specific biomarkers to identify such cancers as early as possible.
Ravinder Anand-Ivell +5 more
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, 2021 Winner of the Mollie Holman Doctoral Medal for Excellence. Two orphan leucine-rich repeat-containing G protein-coupled receptors were recently identified as targets for the relaxin family peptides relaxin and insulin-like peptide (INSL) 3. Relaxin is the cognate ligand for relaxin family peptide receptor (RXFP) 1, whereas INSL3 is the ligand for RXFP2.
Michelle L. Halls
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