Results 31 to 40 of about 1,025 (152)

A novel role for relaxin-2 in the pathogenesis of primary varicosis. [PDF]

PLoS ONE, 2012
BACKGROUND: Varicose veins affect up to 40% of men and up to 51% of women. The pathophysiology of primary varicosis is poorly understood. Theories ranging from incompetence of the venous valves to structural changes in the vein wall have been proposed ...
Julia Adams, Sarah Schott, Arno Bern, Matthias Renz, Kristian Ikenberg, Claus Garbe, Christian Busch   +6 more
doaj   +1 more source

Identification of Critical Genes for Ovine Horn Development Based on Transcriptome during the Embryonic Period

Biology, 2023
Horns, also known as headgear, are a unique structure of ruminants. As ruminants are globally distributed, the study of horn formation is critical not only for increasing our understanding of natural and sexual selection but also for the breeding of ...
Yuanyuan Luan, Shangjie Wu, Mingkun Wang, Yabin Pu, Qianjun Zhao, Yuehui Ma, Lin Jiang, Xiaohong He   +7 more
doaj   +1 more source

Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat

Reproductive Biology and Endocrinology, 2007
Background Relaxin is the endogenous ligand of the G-protein coupled receptor RXFP1, previously known as LGR7. In humans relaxin can also activate, but with lower affinity, the closely related receptor for the insulin-like peptide from Leydig cells ...
Porto Catarina S, Avellar Maria CW, Queiróz Daniel BC, Pimenta Maristela T, Cardoso Laís C, Filonzi Marcelo, Lazari Maria FM   +6 more
doaj   +1 more source

Changes in Knee Laxity and Relaxin Receptor Isoforms Expression (RXFP1/RXFP2) in the Knee throughout Estrous Cycle Phases in Rodents. [PDF]

PLoS ONE, 2016
The changes in knee laxity and relaxin receptor expression at different phases of rodent estrous cycle are not known. Here, changes in the parameter were investigated in rats at different phases of the estrous cycle. Estrous cycle phases of intact female
Firouzeh Dehghan, Rahman Soori, Parvin Dehghan, Khadijeh Gholami, Sekaran Muniandy, Mohammad Ali Azarbayjani, Ashril Yusof   +6 more
doaj   +1 more source

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

Scientific Reports, 2017
Relaxin family peptide receptor 2 (RXFP2) is a GPCR known for its role in reproductive function. It is structurally related to the human relaxin receptor RXFP1 and can be activated by human gene-2 (H2) relaxin as well as its cognate ligand insulin-like ...
Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J. Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J. Petrie, Paul R. Gooley, Ross A. D. Bathgate   +9 more
doaj   +1 more source

Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques

Reproductive Biology and Endocrinology, 2010
Background Although insulin-like 3 (INSL3) has been identified in the gonad of both sexes in many species, there are only limited reports on the distribution of INSL3 and its receptor, relaxin/insulin-like family peptide receptor 2 (RXFP2), in the ...
Jensen Jeffrey T, Patta Maristela C, Yao Shan, Hanna Carol B, Wu Xuemei   +4 more
doaj   +1 more source

A 1.8‐kb insertion in the 3′‐UTR of RXFP2 is associated with polledness in sheep [PDF]

Animal Genetics, 2015
Sheep breeds show a broad spectrum of different horn phenotypes. In most modern production breeds, sheep are polled (absence of horns), whereas horns occur mainly in indigenous breeds. Previous studies mapped the responsible locus to the region of the RXFP2 gene on ovine chromosome 10.
Wiedemar, Natalie, Drögemüller, Cord
openaire   +5 more sources

Ovine relaxin family peptide receptor 2 (RXFP2) gene polymorphism – no association with cryptorchidism

Indian Journal of Animal Sciences, 2019
The polymorphism in ovine relaxin family peptide receptor 2 gene and the relevance of earlier established human and mice cryptorchidism associated SNP’s in Mandya and Hassan Sheep was studied. Genomic DNA was extracted from 60 cryptorchid and 80 normal
G S NAVEEN KUMAR, C S NAGARAJA, R NAGARAJA, M R JAYASHANKAR, M A SUNIL KUMAR   +4 more
doaj   +1 more source

Synthesis of fluorescent analogues of relaxin family peptides and their preliminary in vitro and in vivo characterization

Frontiers in Chemistry, 2013
Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in humans and rodents.
Linda eChan, Linda eChan, Craig eSmith, Craig eSmith, Berenice eChua, Feng eLin, Ross eBathgate, Ross eBathgate, Ross eBathgate, Frances eSeparovic, Andrew eGundlach, Andrew eGundlach, M. Akhter eHossain, M. Akhter eHossain, M. Akhter eHossain, John eWade, John eWade, John eWade   +17 more
doaj   +1 more source

Relaxin-Family Peptide Receptors 1 and 2 Are Fully Functional in the Bovine

Frontiers in Physiology, 2017
In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep.
Yanzhenzi Dai, Yanzhenzi Dai, Richard Ivell, Richard Ivell, Richard Ivell, Xuan Liu, Dana Janowski, Ravinder Anand-Ivell, Ravinder Anand-Ivell   +8 more
doaj   +1 more source