Male Seminal Relaxin Contributes to Induction of the Post-mating Cytokine Response in the Female Mouse Uterus [PDF]
Frontiers in Physiology, 2017 The hormone relaxin is important in female reproduction for embryo implantation, cardiovascular function, and during labor and lactation. Relaxin is also synthesized in males by organs of the male tract.
Danielle J. Glynn +9 more
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Comparative distribution of relaxin-3 inputs and calcium-binding protein-positive neurons in rat amygdala [PDF]
Frontiers in Neuroanatomy, 2016 The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety disorders, depression, addiction,
Fabio N Santos +7 more
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Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4 [PDF]
Communications BiologyThe human relaxin family peptide receptors RXFP3 and RXFP4 play important physiological roles through interactions with endogenous hormones, relaxin-3 and insulin-like peptide 5 (INSL5). They are implicated in certain neurological and metabolic disorders.
Yan Chen +6 more
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Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats [PDF]
Fluids and Barriers of the CNSOxidative stress and neuronal apoptosis could be an important factor leading to post-hemorrhagic consequences after germinal matrix hemorrhage (GMH). Previously study have indicated that relaxin 2 receptor activation initiates anti-oxidative stress and ...
Jun Liu +13 more
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Mediation Effect of Relaxin in Cerebrospinal Fluid on the Association Between Smoking and Sleep [PDF]
Nature and Science of SleepZeping Xu,1,* Mingwei Ma,2,* Yanlong Liu,2,* Jiayi Tang,3 Xingguang Luo,4 Yu-Hsin Chen,2 Kexin Wang,2 Xiyi Chen,2 Yimin Kang,5 Ke Zheng,6 Weiming Hu,7 Li Chen,2 Fan Wang,8 Yuyu Wu9,10 1Department of Pharmacy, Ningbo Medical Center Li Huili ...
Xu Z +13 more
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Do Relaxin Levels Impact Hip Injury Incidence in Women? A Scoping Review
Frontiers in Endocrinology, 2022 PurposeThe aim of this review is to assess the current evidence regarding the impact of relaxin on incidence of soft tissue hip injuries in women.MethodsA trained research librarian assisted with searches of PubMed, Embase, CINAHL, and SPORTDiscus, with ...
Emily A. Parker +5 more
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FACETS, 2021 The effect of treatment with human relaxins on cell death was studied in oxygen- and glucose-deprived brain slices. In addition, involvement of nitric oxide and the relaxin receptor, RXFP3, was studied.
Nicholas P. DeAdder +2 more
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Scientific Reports, 2022 Relaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation and fibrosis are pivotal
Alana Aragón-Herrera +14 more
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Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model. [PDF]
PLoS ONE, 2016 Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur.
Nadine Haase +7 more
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A novel role for relaxin-2 in the pathogenesis of primary varicosis. [PDF]
PLoS ONE, 2012 BACKGROUND: Varicose veins affect up to 40% of men and up to 51% of women. The pathophysiology of primary varicosis is poorly understood. Theories ranging from incompetence of the venous valves to structural changes in the vein wall have been proposed ...
Julia Adams +6 more
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