Relaxin-2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat. [PDF]
FASEB JCardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Vázquez-Abuín X +11 more
europepmc +2 more sources
Non-Pharmacological Interventions for the Treatment of Lumbopelvic Pain in Pregnant Women: A Systematic Review Protocol Using the TIDieR Checklist. [PDF]
Musculoskeletal CareABSTRACT Background Lumbopelvic pain (LPP) is one of the most common complaints during pregnancy, with a reported prevalence of 63%. During pregnancy, treatment should preferably be non‐invasive. However, scientific evidence on non‐pharmacological interventions for pregnant women with LPP is still limited. Objective To synthesise the available evidence
Leite MCVM +4 more
europepmc +2 more sources
Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4 [PDF]
Communications BiologyThe human relaxin family peptide receptors RXFP3 and RXFP4 play important physiological roles through interactions with endogenous hormones, relaxin-3 and insulin-like peptide 5 (INSL5). They are implicated in certain neurological and metabolic disorders.
Yan Chen +6 more
doaj +2 more sources
FACETS, 2021 The effect of treatment with human relaxins on cell death was studied in oxygen- and glucose-deprived brain slices. In addition, involvement of nitric oxide and the relaxin receptor, RXFP3, was studied.
Nicholas P. DeAdder +2 more
doaj +1 more source
Do Relaxin Levels Impact Hip Injury Incidence in Women? A Scoping Review
Frontiers in Endocrinology, 2022 PurposeThe aim of this review is to assess the current evidence regarding the impact of relaxin on incidence of soft tissue hip injuries in women.MethodsA trained research librarian assisted with searches of PubMed, Embase, CINAHL, and SPORTDiscus, with ...
Emily A. Parker +5 more
doaj +1 more source
Scientific Reports, 2022 Relaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation and fibrosis are pivotal
Alana Aragón-Herrera +14 more
doaj +1 more source
Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model. [PDF]
PLoS ONE, 2016 Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur.
Nadine Haase +7 more
doaj +1 more source
A novel role for relaxin-2 in the pathogenesis of primary varicosis. [PDF]
PLoS ONE, 2012 BACKGROUND: Varicose veins affect up to 40% of men and up to 51% of women. The pathophysiology of primary varicosis is poorly understood. Theories ranging from incompetence of the venous valves to structural changes in the vein wall have been proposed ...
Julia Adams +6 more
doaj +1 more source
Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function. [PDF]
PLoS ONE, 2012 Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the nucleus incertus (NI), in the pontine periventricular gray.
Gabrielle E Callander +6 more
doaj +1 more source
Relaxin inhibits patellar tendon healing in rats: a histological and biochemical evaluation
BMC Musculoskeletal Disorders, 2019 Background Female patients are more likely to have tendon injuries than males, especially those who has a higher concentration of relaxin. Previous studies have demonstrated that relaxin attenuates extracellular matrix (ECM) formation.
Tianpeng Xu +11 more
doaj +1 more source