Results 21 to 30 of about 21,756 (262)

Relaxin protects astrocytes from hypoxia in vitro.

PLoS ONE, 2014
The peptide relaxin has recently been shown to protect brain tissues from the detrimental effects of ischemia. To date, the mechanisms for this remain unclear. In order to investigate the neuroprotective mechanisms by which relaxin may protect the brain,
Jordan M Willcox, Alastair J S Summerlee
doaj   +1 more source

Sphingosine 1-phosphate receptors: do they have a therapeutic potential in cardiac fibrosis? [PDF]

, 2017
Sphingosine 1-phosphate (S1P) is a bioactive lipid that is characterized by a peculiar mechanism of action. In fact, S1P, which is produced inside the cell, can act as an intracellular mediator, whereas after its export outside the cell, it can act as ...
Frati, Alessia, Meacci, Elisabetta, Monaco, Lucia, Pierucci, Federica, Vestri, Ambra   +4 more
core   +2 more sources

Evolution of the relaxin-like peptide family

BMC Evolutionary Biology, 2005
Background The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6.
Tregear Geoffrey W, Speed Terence P, Wilkinson Tracey N, Bathgate Ross AD   +3 more
doaj   +1 more source

Characterizing relaxin receptor expression and exploring relaxin’s effect on tissue remodeling/fibrosis in the human bladder

BMC Urology, 2020
Background Relaxin is an endogenous protein that has been shown to have antifibrotic properties in various organ systems. There has been no characterization of relaxin’s role in the human bladder.
Edward C. Diaz, Mason Briggs, Yan Wen, Guobing Zhuang, Shannon L. Wallace, Amy D. Dobberfuhl, Chia-Sui Kao, Bertha C. Chen   +7 more
doaj   +1 more source

Chronic treatment with serelaxin mitigates adverse remodeling in a murine model of ischemic heart failure and modulates bioactive sphingolipid signaling

Scientific Reports, 2022
Relaxin is a pleiotropic hormone demonstrated to confer cardioprotection in animal models of myocardial infarction and ischemic heart failure by modulating inflammation, fibrosis and arrhythmogenesis.
Teja Devarakonda, Juan Valle Raleigh, Adolfo G. Mauro, Johana M. Lambert, Lauren Ashley Cowart, Fadi N. Salloum   +5 more
doaj   +1 more source

A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease [PDF]

, 2007
Dupuytren’s disease (DD) is a common fibrotic condition of the palmar fascia, leading to deposition of collagen-rich cords and finger contractions. The metzincin superfamily contains key enzymes in the turnover of collagen and other extracellular matrix ...
Adrian J. Chojnowski, Baker, Baragi, Bird, Bisson, Bretz, Brinckerhoff, Brown, Bunker, Clark, Daniels, Drummond, d’Ortho, Graham P. Riley, Hutchinson, Ian M. Clark, Iredale, Jones, Jung, Kashiwagi, Kevorkian, Knauper, Le Goff, Luck, Mikkelsen, Mirastschijski, Moyer, Murphy, Nuttall, Ohuchi, Phillip Johnston, Porter, Porter, Price, Qian, Rayan, Rose K. Davidson, Schaer, Scott, Simon T. Donell, Smith, Tarlton, Tarpila, Thurston, Ulrich, Unemori, Unemori, Unemori, Williams   +48 more
core   +1 more source

RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway

Frontiers in Physiology, 2018
Background: Relaxins are small peptide hormones, which are novel candidate molecules that play important roles in cardiometablic syndrome. Relaxins are structurally related to the insulin hormone superfamily, which provide vasodilatory effects by ...
Xiaoming Lian, Sandra Beer-Hammer, Gabriele M. König, Evi Kostenis, Bernd Nürnberg, Maik Gollasch, Maik Gollasch   +6 more
doaj   +1 more source

Phylogenomic analysis reveals extensive phylogenetic mosaicism in the Human GPCR Superfamily [PDF]

, 2007
A novel high throughput phylogenomic analysis (HTP) was applied to the rhodopsin G-protein coupled receptor (GPCR) family. Instances of phylogenetic mosaicism between receptors were found to be frequent, often as instances of correlated mosaicism and ...
Allaby, Robin G., Woodwark, Mathew
core   +1 more source

Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter

IBRO Reports, 2020
Modern neuroscience utilizes transgenic techniques extensively to study the activity and function of brain neural networks. A key feature of this approach is its compatibility with molecular methods for selective transgene expression in neuronal circuits
Alexander D. Wykes, Sherie Ma, Ross A.D. Bathgate, Andrew L. Gundlach   +3 more
doaj   +1 more source

Carbachol increases intracellular free calcium concentrations in human granulosa-lutein cells [PDF]

, 1992
We investigated whether the stimulation of human granulosa-lutein cells with muscarinic and nicotinic receptor agonists can cause increases in intracellular free calcium (Ca2+), using Fura-2 microfluorimetry.
Föhr, K. J., Gratzl, Manfred, Mayerhofer, Artur, Sterzik, K.   +3 more
core   +1 more source