Results 21 to 30 of about 11,028 (173)

Male Seminal Relaxin Contributes to Induction of the Post-mating Cytokine Response in the Female Mouse Uterus

Frontiers in Physiology, 2017
The hormone relaxin is important in female reproduction for embryo implantation, cardiovascular function, and during labor and lactation. Relaxin is also synthesized in males by organs of the male tract.
Danielle J. Glynn, Danielle J. Glynn, Kee Heng, Darryl L. Russell, David J. Sharkey, Sarah A. Robertson, Ravinder Anand-Ivell, Ravinder Anand-Ivell, Richard Ivell, Richard Ivell   +9 more
doaj   +1 more source

Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter

IBRO Reports, 2020
Modern neuroscience utilizes transgenic techniques extensively to study the activity and function of brain neural networks. A key feature of this approach is its compatibility with molecular methods for selective transgene expression in neuronal circuits
Alexander D. Wykes, Sherie Ma, Ross A.D. Bathgate, Andrew L. Gundlach   +3 more
doaj   +1 more source

Relaxin treatment stimulates the differentiation of mesenchymal stem cells into osteoblasts

Journal of Dental Sciences, 2023
Background/purpose: Several studies have determined that relaxin stimulates differentiation and regulates the activity of mature osteoclasts, but little is known about its effect on the differentiation of mesenchymal cells towards the osteogenic lineage.
Lina M. Escobar, Zita Bendahan, Camilo Garcia, Jaime E. Castellanos   +3 more
doaj   +1 more source

Biology of primate relaxin: A paracrine signal in early pregnancy?

Reproductive Biology and Endocrinology, 2004
Relaxin is a peptide hormone that exerts numerous effects in a variety of tissues across a broad range of species. Although first identified more than 75 years ago interest in relaxin biology has waxed and waned over the years consistent with peaks and ...
Hayes Eric S
doaj   +1 more source

Relaxin does not improve Angiotensin II-induced target-organ damage.

PLoS ONE, 2014
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage.
Nadine Haase, Julianna Rugor, Lukasz Przybyl, Fatimunnisa Qadri, Dominik N Müller, Ralf Dechend   +5 more
doaj   +1 more source

H3 Relaxin Alleviates Migration, Apoptosis and Pyroptosis Through P2X7R-Mediated Nucleotide Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Activation in Retinopathy Induced by Hyperglycemia

Frontiers in Pharmacology, 2020
Introduction: P2X7R excitation-interrelated NLRP3 inflammasome activation induced by high glucose contributes to the pathogenesis of diabetic retinopathy (DR).
Kelaier Yang, Jiannan Liu, Xiaohui Zhang, Ziqi Ren, Lei Gao, Ying Wang, Wenjian Lin, Xuefei Ma, Ming Hao, Hongyu Kuang   +9 more
doaj   +1 more source

Effect of relaxin‐3 on Kiss‐1, gonadotropin‐releasing hormone, and gonadotropin subunit gene expression

Reproductive Medicine and Biology, 2019
Purpose Relaxin‐3 is a hypothalamic neuropeptide that belongs to the insulin superfamily. We examined whether relaxin‐3 could affect hypothalamic Kiss‐1, gonadotropin‐releasing hormone (GnRH), and pituitary gonadotropin subunit gene expression.
Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Hiroe Okada, Satoru Kyo   +5 more
doaj   +1 more source

Relaxin as a Therapeutic Target for the Cardiovascular Complications of Diabetes

Frontiers in Pharmacology, 2018
Cardiovascular complications are the major cause of mortality in patients with diabetes. This is closely associated with both macrovascular and microvascular complications of diabetes, which lead to organ injuries in diabetic patients.
Hooi Hooi Ng, Hooi Hooi Ng, Hooi Hooi Ng, Chen Huei Leo, Chen Huei Leo, Laura J. Parry, Rebecca H. Ritchie, Rebecca H. Ritchie   +7 more
doaj   +1 more source

Diverse signalling mechanisms used by relaxin in natural cells and tissues: the evolution of a "neohormone"

, 2007
The small peptide hormone relaxin is a member of a rapidly evolving family of hormones and growth factors, whose mode of action appears to be particularly adapted to purely mammalian physiology.
Heng, K., Anand Ivell, R., Ivell, R.
core   +1 more source

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Nature Communications, 2016
The mechanism by which relaxin activates the relaxin family peptide receptor-1 is poorly understood. Here, Sethi et al.identify a relaxin binding site in an extracellular linker between the LDLa and LRR domains and propose that relaxin binding stabilizes
Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J. Scott, Emma J. Petrie, Ross A. D. Bathgate, Paul R. Gooley   +7 more
doaj   +1 more source