Results 11 to 20 of about 11,028 (173)

Relaxin protects astrocytes from hypoxia in vitro.

PLoS ONE, 2014
The peptide relaxin has recently been shown to protect brain tissues from the detrimental effects of ischemia. To date, the mechanisms for this remain unclear. In order to investigate the neuroprotective mechanisms by which relaxin may protect the brain,
Jordan M Willcox, Alastair J S Summerlee
doaj   +2 more sources

Targeting the Relaxin Pathway for Liver Disease Treatment [PDF]

European Medical Journal Hepatology, 2018
Hepatic fibrosis is a progressive disease with few treatment options outside of transplantation. Relaxin is a member of the insulin/relaxin superfamily of peptide hormones. Originally known for its roles in pregnancy, relaxin promotes reproductive tissue
Robert G. Bennett
doaj   +1 more source

Evolution of the relaxin-like peptide family [PDF]

BMC Evolutionary Biology, 2005
Background The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6.
Tregear Geoffrey W, Speed Terence P, Wilkinson Tracey N, Bathgate Ross AD   +3 more
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Characterizing relaxin receptor expression and exploring relaxin’s effect on tissue remodeling/fibrosis in the human bladder

BMC Urology, 2020
Background Relaxin is an endogenous protein that has been shown to have antifibrotic properties in various organ systems. There has been no characterization of relaxin’s role in the human bladder.
Edward C. Diaz, Mason Briggs, Yan Wen, Guobing Zhuang, Shannon L. Wallace, Amy D. Dobberfuhl, Chia-Sui Kao, Bertha C. Chen   +7 more
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Mediation Effect of Relaxin in Cerebrospinal Fluid on the Association Between Smoking and Sleep [PDF]

Nature and Science of Sleep
Zeping Xu,1,* Mingwei Ma,2,* Yanlong Liu,2,* Jiayi Tang,3 Xingguang Luo,4 Yu-Hsin Chen,2 Kexin Wang,2 Xiyi Chen,2 Yimin Kang,5 Ke Zheng,6 Weiming Hu,7 Li Chen,2 Fan Wang,8 Yuyu Wu9,10 1Department of Pharmacy, Ningbo Medical Center Li Huili ...
Xu Z, Ma M, Liu Y, Tang J, Luo X, Chen YH, Wang K, Chen X, Kang Y, Zheng K, Hu W, Chen L, Wang F, Wu Y   +13 more
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Relaxin stimulates leukocyte adhesion and migration through a relaxin receptor LGR7-dependent mechanism [PDF]

, 2006
Leukocytes are critical effectors of inflammation and tumor biology. Chemokine-like factors produced by such inflammatory sites are key mediators of tumor growth that activate leukocytic recruitment and tumor infiltration and suppress immune surveillance.
Alice L. Mui, Michael E. Cox, Mui, Alice, Colleen C. Nelson, Kevin A. Figueiredo, Cox, Michael, Figueiredo, Kevin, Nelson, Colleen   +7 more
core   +1 more source

The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease

Molecular Genetics & Genomic Medicine, 2020
Background Relaxin/relaxin family peptide receptor 1 (RXFP1) signaling is important for both normal physiology and disease. Strong preclinical evidence supports relaxin as a potent antifibrotic molecule.
Ting‐Yun Chen, Xiaoyun Li, Ching‐Hsia Hung, Harinath Bahudhanapati, Jiangning Tan, Daniel J. Kass, Yingze Zhang   +6 more
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Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/β-catenin signaling pathway

Renal Failure, 2022
Renal fibrosis is a common characteristic and the final pathological mechanism of chronic kidney disease (CKD). Although CKD remains incurable, inhibition of renal fibrosis is beneficial to inhibit the CKD process.
Chen Feiteng, Chen Lei, Li Deng, Xu Chaoliang, Xu Zijie, Shao Yi, Sha Minglei   +6 more
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Chronic treatment with serelaxin mitigates adverse remodeling in a murine model of ischemic heart failure and modulates bioactive sphingolipid signaling

Scientific Reports, 2022
Relaxin is a pleiotropic hormone demonstrated to confer cardioprotection in animal models of myocardial infarction and ischemic heart failure by modulating inflammation, fibrosis and arrhythmogenesis.
Teja Devarakonda, Juan Valle Raleigh, Adolfo G. Mauro, Johana M. Lambert, Lauren Ashley Cowart, Fadi N. Salloum   +5 more
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RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway

Frontiers in Physiology, 2018
Background: Relaxins are small peptide hormones, which are novel candidate molecules that play important roles in cardiometablic syndrome. Relaxins are structurally related to the insulin hormone superfamily, which provide vasodilatory effects by ...
Xiaoming Lian, Sandra Beer-Hammer, Gabriele M. König, Evi Kostenis, Bernd Nürnberg, Maik Gollasch, Maik Gollasch   +6 more
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