Precision-Cut Bladder Slices: A Novel Model for the Study of Bladder Fibrosis and Potential Anti-Fibrotic Agents. [PDF]
Int J UrolABSTRACT Objectives Precision‐cut tissue slice culture is an innovative ex vivo approach for studying fibrosis pathogenesis. Here, we report for the first time the use of human precision‐cut bladder slices (PCBS) to investigate fibrotic changes and evaluate anti‐fibrotic compounds.
Lu Y +5 more
europepmc +2 more sources
The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
Molecular Genetics & Genomic Medicine, 2020 Background Relaxin/relaxin family peptide receptor 1 (RXFP1) signaling is important for both normal physiology and disease. Strong preclinical evidence supports relaxin as a potent antifibrotic molecule.
Ting‐Yun Chen +6 more
doaj +1 more source
Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester [PDF]
, 2009 Objectives: Defective implantation is a mechanism for recurrent pregnancy loss (RPL). We sought to determine whether the serum expression of human relaxin-2 (RLX) is impaired in women with a history of RPL.
Bogic +30 more
core +2 more sources
The O-carbamoyl-transferase albis is responsible for the modification of albicidin [PDF]
, 2016 Albicidin is a potent antibiotic and phytotoxin produced by the sugarcane pathogenic bacterium Xanthomonas albilineans which targets the plant and bacterial DNA gyrase.[1] The infection occurs through the xylem vessels of the plants where the pathogen ...
Arasté, Julie +10 more
core +1 more source
Relaxin inhibits patellar tendon healing in rats: a histological and biochemical evaluation
BMC Musculoskeletal Disorders, 2019 Background Female patients are more likely to have tendon injuries than males, especially those who has a higher concentration of relaxin. Previous studies have demonstrated that relaxin attenuates extracellular matrix (ECM) formation.
Tianpeng Xu +11 more
doaj +1 more source
Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function. [PDF]
PLoS ONE, 2012 Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the nucleus incertus (NI), in the pontine periventricular gray.
Gabrielle E Callander +6 more
doaj +1 more source
Concerted action of human chorionic gonadotropin and norepinephrine on intracellular-free calcium in human granulosa-lutein cells [PDF]
, 1993 Luteal cells are known to possess receptors for LH/hCG and receptors of the beta-adrenergic type. Interactions of specific agonists with either receptor lead to the activation of adenylate cyclase and subsequently to an increase of cAMP.
Föhr, K. J. +5 more
core +1 more source
Peripartum cardiomyopathy: diagnosis and management [PDF]
, 2017 No abstract ...
Coats, Caroline J. +5 more
core +1 more source
Renal Failure, 2022 Renal fibrosis is a common characteristic and the final pathological mechanism of chronic kidney disease (CKD). Although CKD remains incurable, inhibition of renal fibrosis is beneficial to inhibit the CKD process.
Chen Feiteng +6 more
doaj +1 more source
Endometrial expression of relaxin and relaxin receptor in endometriosis [PDF]
Fertility and Sterility, 2010 Our studies demonstrate significantly lower expression of relaxin and its receptor in ectopic endometriotic tissues than their expression in eutopic endometrium and in endometrium from normal controls. These data suggest that in normal and eutopic endometrium, relaxin may exert a protective effect against endometriosis.
MORELLI, S. S. +6 more
openaire +3 more sources